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Metabolic Changes in the Exercise Programs for Chronic Kidney Disease...
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Metabolic Changes in the Exercise Programs for Chronic Kidney Disease Patients

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 5758

Special Issue Editor

Dr. Jieun Oh

E-Mail Website
Guest Editor
Kangdong Sacred Heart Hospital, Hallym University, Seoul, Korea
Interests: exercise; chronic kidney disease; metabolomics

Special Issue Information

Dear Colleagues,

Exercise has been reported to improve physical fitness and psychological health in chronic kidney disease (CKD) and dialysis patients. CKD patients are deconditioned with muscle wasting and altered nutritional status  and dialysis leads to metabolic changes such as hypovolemia, electrolyte imbalance, and systemic inflammation.

Exercise has many advantages and can ameliorate a sustained decline in functional status. However, the mechanisms underlying its benefits are unknown. This Special Issue is dedicated to the investigation of biological effects and metabolic changes related to exercise in CKD patients. The topics that will be covered include, but are not limited to, the search for metabolites of plasma or breath samples, neurophysiologic or neuromuscular studies, functional studies related to posture or balance, or tools for evaluating mental well-being. Researchers can implement an exercise training program or measure physical activity using a smart watch or cell phone. Articles using animal models or dealing with other challenging issues are also welcomed.

Dr. Jieun Oh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Exercise
  • Chronic Kidney Disease
  • Hemodialysis
  • Sarcopenia
  • Nutrition
  • Inflammation
  • Mental health
  • Metabolite biomarker.

Published Papers (3 papers)

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13 pages, 1293 KiB  
Article
Home-Based Exercise in Elderly Patients with Claudication and Chronic Kidney Disease Is Associated with Lower Progressive Renal Function Worsening: A 5-Year Retrospective Study
by Giovanni Piva, Anna Crepaldi, Nicola Lamberti, Lorenzo Caruso, Natascia Rinaldo, Roberto Manfredini, Pablo Jesus López-Soto, Vincenzo Gasbarro, Fabio Manfredini and Alda Storari
Metabolites 2023, 13(1), 56; https://doi.org/10.3390/metabo13010056 - 30 Dec 2022
Cited by 1 | Viewed by 1547
Abstract
This observational study aimed to monitor the 5-year trends of kidney function in patients with peripheral artery disease (PAD) and concomitant chronic kidney disease (CKD) enrolled or not enrolled into a rehabilitative exercise program. Sixty-six patients (aged 72 ± 10, males n = [...] Read more.
This observational study aimed to monitor the 5-year trends of kidney function in patients with peripheral artery disease (PAD) and concomitant chronic kidney disease (CKD) enrolled or not enrolled into a rehabilitative exercise program. Sixty-six patients (aged 72 ± 10, males n = 52) at KDOQI stages III-IV and PAD at Rutherford’s stage I-III were included in the study, with a group (Exercise, EX; n = 32) receiving a 6-month structured pain-free home-based walking program and a group (Control, CO; n = 34) receiving walking advice and optimal nephrological care. Outcomes included kidney function measured through serum creatinine (sCr) and clinical outcomes, including the rate of advance of CKD stages and admission to dialysis, revascularizations, and hospitalizations. At baseline, the two groups were comparable for age, nephropathy, medications, comorbidities, and PAD severity. Patients in the EX group safely completed the exercise program. SCr values were slightly increased in EX (baseline: 2.35 ± 0.32; 5-year: 2.71 ± 0.39 mg/dL) and progressively worsened in CO (baseline: 2.30 ± 0.31; 5-year 4.22 ± 0.42 mg/dL), with a significant between-group difference (p = 0.002). The control group also showed a higher number of dialysis admissions (5 vs. 0, p = 0.025) and advancing CKD stage as well a higher risks for lower limb revascularization (hazard ratio: 2.59; 95%CI: 1.11–6.02; p = 0.027) and for all-cause hospitalization (hazard ratio: 1.77; 95%CI: 1.05–2.97; p = 0.031). PAD-CKD patients enrolled in a low-moderate intensity home-exercise program showed more favorable long-term trends in kidney function and clinical outcomes than patients with usual care. These preliminary observations need to be confirmed in randomized trials. Full article
(This article belongs to the Special Issue Metabolic Changes in the Exercise Programs for Chronic Kidney Disease Patients)
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10 pages, 943 KiB  
Article
Exercise Training Ameliorates Renal Oxidative Stress in Rats with Chronic Renal Failure
by Seiko Yamakoshi, Takahiro Nakamura, Lusi Xu, Masahiro Kohzuki and Osamu Ito
Metabolites 2022, 12(9), 836; https://doi.org/10.3390/metabo12090836 - 04 Sep 2022
Cited by 3 | Viewed by 1648
Abstract
In patients with chronic kidney disease, exercise training with moderate intensity protects renal function and improves mortality. However, the mechanisms of the renal protective effects of exercise training in chronic kidney disease have not been clarified. This study investigated the effects of exercise [...] Read more.
In patients with chronic kidney disease, exercise training with moderate intensity protects renal function and improves mortality. However, the mechanisms of the renal protective effects of exercise training in chronic kidney disease have not been clarified. This study investigated the effects of exercise training on renal NADPH oxidative and xanthine oxidase, which are major sources of reactive oxygen species, in rats with chronic renal failure. Six-week-old, male Sprague–Dawley rats were divided into the sham operation, 5/6 nephrectomy (Nx)+ sedentary, and Nx+ exercise training groups. The Nx+ exercise training group underwent treadmill running. After 12 weeks, systolic blood pressure, renal function, malondialdehyde, renal NADPH oxidase, and xanthine oxidase were examined. Nx induced hypertension, proteinuria, and renal dysfunction, and exercise training attenuated these disorders. Although the plasma levels of malondialdehyde were not different among the group, urinary levels were increased by Nx and decreased by exercise training. Renal activity and expression of NADPH oxidase and xanthine oxidase were increased by Nx and decreased by exercise training. These results indicate that exercise training attenuates hypertension and renal dysfunction and ameliorates NADPH oxidase and xanthine oxidase in rats with chronic renal failure, suggesting that the reduction of reactive oxygen species generation may be involved in the renal protective effects of exercise training. Full article
(This article belongs to the Special Issue Metabolic Changes in the Exercise Programs for Chronic Kidney Disease Patients)
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Other

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14 pages, 1219 KiB  
Systematic Review
Effects of Exercise on Inflammatory Markers in Individuals with Chronic Kidney Disease: A Systematic Review and Meta-Analysis
by Victor M. Baião, Vinícius A. Cunha, Marvery P. Duarte, Francini P. Andrade, Aparecido P. Ferreira, Otávio T. Nóbrega, João L. Viana and Heitor S. Ribeiro
Metabolites 2023, 13(7), 795; https://doi.org/10.3390/metabo13070795 - 27 Jun 2023
Cited by 3 | Viewed by 1239
Abstract
Individuals with chronic kidney disease (CKD) have a systemic inflammatory state. We assessed the effects of exercise on inflammatory markers in individuals with CKD. An electronic search was conducted, including MEDLINE. Experimental clinical trials that investigated the effects of exercise on inflammatory markers [...] Read more.
Individuals with chronic kidney disease (CKD) have a systemic inflammatory state. We assessed the effects of exercise on inflammatory markers in individuals with CKD. An electronic search was conducted, including MEDLINE. Experimental clinical trials that investigated the effects of exercise on inflammatory markers in individuals with CKD at all stages were included. Meta-analyses were conducted using the random-effects model and standard mean difference (SMD). Subgroup analyses were performed for resistance, aerobic, and combined exercise interventions. Twenty-nine studies were included in the meta-analyses. Exercise interventions showed significant reductions in C-reactive protein (CRP) (SMD: −0.23; 95% CI: −0.39 to −0.06), interleukin (IL)-6 (SMD: −0.35; 95% CI: −0.57, −0.14), and tumor necrosis factor-alpha (TNF-α) (SMD: −0.63, 95% CI: −1.01, −0.25) when compared with the controls. IL-10 levels significantly increased (SMD: 0.66, 95% CI: 0.09, 1.23) with exercise interventions. Resistance interventions significantly decreased CRP (SMD: −0.39, 95% CI: −0.69, −0.09) and TNF-α (SMD: −0.72, 95% CI: −1.20, −0.23) levels, while increasing IL-10 levels (SMD: 0.57, 95% CI: 0.04, 1.09). Aerobic interventions only significantly reduced IL-6 levels (SMD: −0.26, 95% CI: −0.51, −0.01). No significant changes in any inflammatory markers were observed with combined exercise interventions. Exercise interventions are effective as an anti-inflammatory therapy in individuals with CKD compared to usual care control groups. Resistance interventions seem to promote greater anti-inflammatory effects. Full article
(This article belongs to the Special Issue Metabolic Changes in the Exercise Programs for Chronic Kidney Disease Patients)
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