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Special Issue "Metabolic Changes in the Exercise Programs for Chronic Kidney Disease Patients"

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Kangdong Sacred Heart Hospital, Hallym University, Seoul, Korea
Interests: exercise; chronic kidney disease; metabolomics

Special Issue Information

Dear Colleagues,

Exercise has been reported to improve physical fitness and psychological health in chronic kidney disease (CKD) and dialysis patients. CKD patients are deconditioned with muscle wasting and altered nutritional status and dialysis leads to metabolic changes such as hypovolemia, electrolyte imbalance, and systemic inflammation.

Exercise has many advantages and can ameliorate a sustained decline in functional status. However, the mechanisms underlying its benefits are unknown. This Special Issue is dedicated to the investigation of biological effects and metabolic changes related to exercise in CKD patients. The topics that will be covered include, but are not limited to, the search for metabolites of plasma or breath samples, neurophysiologic or neuromuscular studies, functional studies related to posture or balance, or tools for evaluating mental well-being. Researchers can implement an exercise training program or measure physical activity using a smart watch or cell phone. Articles using animal models or dealing with other challenging issues are also welcomed.

Dr. Jieun Oh
Guest Editor

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Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

Exercise
Chronic Kidney Disease
Hemodialysis
Sarcopenia
Nutrition
Inflammation
Mental health
Metabolite biomarker.

Published Papers (2 papers)

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Research

Open AccessArticle

Home-Based Exercise in Elderly Patients with Claudication and Chronic Kidney Disease Is Associated with Lower Progressive Renal Function Worsening: A 5-Year Retrospective Study

Pablo Jesus López-Soto

Vincenzo Gasbarro

Fabio Manfredini

and

Alda Storari

Metabolites 2023, 13(1), 56; https://doi.org/10.3390/metabo13010056 - 30 Dec 2022

Viewed by 896

Abstract

This observational study aimed to monitor the 5-year trends of kidney function in patients with peripheral artery disease (PAD) and concomitant chronic kidney disease (CKD) enrolled or not enrolled into a rehabilitative exercise program. Sixty-six patients (aged 72 ± 10, males n = 52) at KDOQI stages III-IV and PAD at Rutherford’s stage I-III were included in the study, with a group (Exercise, EX; n = 32) receiving a 6-month structured pain-free home-based walking program and a group (Control, CO; n = 34) receiving walking advice and optimal nephrological care. Outcomes included kidney function measured through serum creatinine (sCr) and clinical outcomes, including the rate of advance of CKD stages and admission to dialysis, revascularizations, and hospitalizations. At baseline, the two groups were comparable for age, nephropathy, medications, comorbidities, and PAD severity. Patients in the EX group safely completed the exercise program. SCr values were slightly increased in EX (baseline: 2.35 ± 0.32; 5-year: 2.71 ± 0.39 mg/dL) and progressively worsened in CO (baseline: 2.30 ± 0.31; 5-year 4.22 ± 0.42 mg/dL), with a significant between-group difference (p = 0.002). The control group also showed a higher number of dialysis admissions (5 vs. 0, p = 0.025) and advancing CKD stage as well a higher risks for lower limb revascularization (hazard ratio: 2.59; 95%CI: 1.11–6.02; p = 0.027) and for all-cause hospitalization (hazard ratio: 1.77; 95%CI: 1.05–2.97; p = 0.031). PAD-CKD patients enrolled in a low-moderate intensity home-exercise program showed more favorable long-term trends in kidney function and clinical outcomes than patients with usual care. These preliminary observations need to be confirmed in randomized trials. Full article

(This article belongs to the Special Issue Metabolic Changes in the Exercise Programs for Chronic Kidney Disease Patients)

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Open AccessArticle

Exercise Training Ameliorates Renal Oxidative Stress in Rats with Chronic Renal Failure

and

Metabolites 2022, 12(9), 836; https://doi.org/10.3390/metabo12090836 - 04 Sep 2022

Viewed by 999

Abstract

In patients with chronic kidney disease, exercise training with moderate intensity protects renal function and improves mortality. However, the mechanisms of the renal protective effects of exercise training in chronic kidney disease have not been clarified. This study investigated the effects of exercise training on renal NADPH oxidative and xanthine oxidase, which are major sources of reactive oxygen species, in rats with chronic renal failure. Six-week-old, male Sprague–Dawley rats were divided into the sham operation, 5/6 nephrectomy (Nx)+ sedentary, and Nx+ exercise training groups. The Nx+ exercise training group underwent treadmill running. After 12 weeks, systolic blood pressure, renal function, malondialdehyde, renal NADPH oxidase, and xanthine oxidase were examined. Nx induced hypertension, proteinuria, and renal dysfunction, and exercise training attenuated these disorders. Although the plasma levels of malondialdehyde were not different among the group, urinary levels were increased by Nx and decreased by exercise training. Renal activity and expression of NADPH oxidase and xanthine oxidase were increased by Nx and decreased by exercise training. These results indicate that exercise training attenuates hypertension and renal dysfunction and ameliorates NADPH oxidase and xanthine oxidase in rats with chronic renal failure, suggesting that the reduction of reactive oxygen species generation may be involved in the renal protective effects of exercise training. Full article

(This article belongs to the Special Issue Metabolic Changes in the Exercise Programs for Chronic Kidney Disease Patients)

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Special Issue "Metabolic Changes in the Exercise Programs for Chronic Kidney Disease Patients"

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