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Special Issue "Metabolic and Endocrine Responses to Stress and Disease in Animal Production"

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A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".

Deadline for manuscript submissions: 31 July 2023 | Viewed by 3631

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Special Issue Editors

Prof. Dr. Romana Turk

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Guest Editor

Department of Pathophysiology, Faculty of Veterinary Medicine, University of Zagreb, 10000 Zagreb, Croatia
Interests: dairy cows; metabolic disease; oxidative stress; bovine mastitis

Prof. Dr. Paola Roncada

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Co-Guest Editor

Department of Health Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy
Interests: proteomics; metabolomics; one health; microbiome; animal health; microbiology
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Special Issue Information

Dear Colleagues,

We are delighted to announce a Special Issue of the high-ranking journal Metabolites that is focused on metabolic and endocrine changes as responses to stress and diseases during animal production.

Stress and diseases during animal production trigger numerous metabolic and endocrine responses influencing animal growth and performance, the quality of products of animal origin, and also animal welfare. In addition, these changes could have a great impact on public health, giving further importance to a One Health approach.

You are warmly welcome to submit a research article or a review paper relevant to the scopes of this Special Issue, which will highly contribute to a better understanding of complex metabolic pathways in different organs the including liver, adipose tissue, and mammary glands; host–pathogen interactions; the role of microbiome and the environmental impacts on animal production; and the influence of animal production on human health. Different novel techniques, including proteomics and metabolomics, could improve the knowledge on an intrigued metabolic network during stress and diseases in animal production.

Prof. Dr. Romana Turk
Prof. Dr. Paola Roncada
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

animal production
stress
lipid metabolism
adipose tissue
liver
mammary gland
milk
microbiome
host-pathogen interaction
proteomics
metabolomics

Published Papers (4 papers)

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Research

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Open AccessArticle

A Pilot Study on Across-Generation Impacts of Maternal Heat Stress on Blood Metabolites of Female Holstein Dairy Calves

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Metabolites 2023, 13(4), 494; https://doi.org/10.3390/metabo13040494 - 29 Mar 2023

Viewed by 999

Abstract

Heat stress (HS) during late gestation implies unfavorable effects on dairy cows and their in-utero heat stressed offspring. The objective of the present study was to elucidate the effect of intrauterine (maternal) HS during the last week of gestation on blood metabolite concentrations of female dairy calves during their first week of life. We defined the mean temperature humidity index (mTHI) during the last gestation week of ≥60 as threshold for maternal HS. In this regard, we compared differences in metabolite concentrations of maternally heat stressed (MHS_CALVES) (n = 14) and not heat stressed (NMHS_CALVES) (n = 33) calves. We identified 15 metabolites from five different biochemical classes (phosphatidylcholines, cholesteryl esters, sphingomyelins, cresols and hexoses) as potential biomarkers for maternal HS in calves. The plasma concentrations of all significantly affected metabolites were lower in MHS_CALVES when compared to NMHS_CALVES. The effect of maternal HS during the last week of gestation on blood metabolite concentrations of the female offspring during the first week after birth might be due to HS induced intergenerational physiological alterations, impaired colostrum quality or epigenetic modifications of the calf genome. The results of this pilot study should be validated in ongoing fully standardized studies. Full article

(This article belongs to the Special Issue Metabolic and Endocrine Responses to Stress and Disease in Animal Production)

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Open AccessArticle

Effect of Supplementation of Lambs with Whole Cottonseed: Impact on Serum Biomarkers and Infection by Gastrointestinal Parasites under Field Conditions

Vitoldo Antonio Kozlowski Neto

Elizabeth Moreira dos Santos Schmidt

Camila Peres Rubio

Naiara Mirelly Marinho da Silva

Renata Tardivo

Ciniro Costa

Paulo Roberto de Lima Meirelles

José Joaquín Cerón

Asta Tvarijonaviciute

and

Alessandro Francisco Talamini do Amarante

Metabolites 2023, 13(3), 398; https://doi.org/10.3390/metabo13030398 - 08 Mar 2023

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Abstract

The purpose of this trial was to evaluate serum levels of oxidative stress biomarkers and biochemical analytes in crossbred lambs during the rearing phase in an integrated crop-livestock system (ICLS) to control gastrointestinal parasites. The experiment used 36 crossbred lambs (cross: Ile de France × White Dorper × Texel) divided into two groups. The WCS group was supplemented with whole cottonseed (WCS), and controls had no supplementation. Body weight, blood collection, and fecal analysis of nematode eggs and Eimeria oocysts counting per gram of feces were performed for each animal within 84 days of experiment. The following serum analytes were determined: total protein, albumin, globulin, cholesterol, haptoglobin, and 10 oxidative stress biomarkers: cupric reducing antioxidant capacity, ferric reducing ability of plasma, trolox equivalent antioxidant capacity, thiol, uric acid, paraoxonase-1, total oxidant status, ferric-xylenol orange, advanced oxidation protein products, and reactive oxygen metabolites derived compounds. The inclusion of WCS suggested the benefit in controlling infection as well as inducing an increase in antioxidants and a decrease in oxidants in lambs naturally infected by gastrointestinal parasites. The combination of WCS and ICLS could be a useful tool in controlling gastrointestinal parasite infection without affecting the production performance. Full article

(This article belongs to the Special Issue Metabolic and Endocrine Responses to Stress and Disease in Animal Production)

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Open AccessArticle

Association between Tryptophan Metabolism and Inflammatory Biomarkers in Dairy Cows with Ketosis

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Metabolites 2023, 13(3), 333; https://doi.org/10.3390/metabo13030333 - 23 Feb 2023

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Abstract

Dairy cows with ketosis have high circulating beta-hydroxybutyric acid (BHBA) concentrations alongside which inflammation is concomitantly developed. Tryptophan (Trp) is an essential amino acid that participates in the regulation of the inflammatory response. However, the association between Trp metabolism and inflammation in dairy cows with ketosis remains unclear. Therefore, blood samples from healthy (n = 10) and ketotic (n = 10) primiparous dairy cows were collected at the calving date and the day of ketosis diagnosis (7 days in milk (7 DIM)). Serum levels of non-esterified fatty acids (NEFA), BHBA, haptoglobin (HP), serum amyloid A (SAA), lipopolysaccharide, and cortisol were analyzed. Tryptophan and its metabolites were quantified using liquid chromatography–tandem mass spectrometry. At 7 DIM, the concentrations of NEFA, BHBA, HP, and SAA were higher and the levels of Trp, kynurenine (KYN), indoleacetic acid, indole-3-lactic acid, and 3-indoxyl sulfate were lower in the dairy cows with ketosis compared with those in the healthy cows. However, the KYN/Trp and melatonin/Trp ratios increased in the cows with ketosis. At the calving date, the serum lipopolysaccharide levels did not differ between the healthy and ketotic cows, whereas the levels of NEFA, HP, and cortisol increased in the ketotic cows. Correlation analysis showed that Trp deficiency and elevated Trp metabolism in the dairy cows occurred during ketosis. Overall, our results suggest that abnormal Trp metabolism may contribute to the pathogenesis of ketosis. Full article

(This article belongs to the Special Issue Metabolic and Endocrine Responses to Stress and Disease in Animal Production)

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Review

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Open AccessReview

Different Types of Glucocorticoids to Evaluate Stress and Welfare in Animals and Humans: General Concepts and Examples of Combined Use

María Botía

Damián Escribano

Silvia Martínez-Subiela

Asta Tvarijonaviciute

Fernando Tecles

Marina López-Arjona

and

José J. Cerón

Metabolites 2023, 13(1), 106; https://doi.org/10.3390/metabo13010106 - 09 Jan 2023

Cited by 1 | Viewed by 1118

Abstract

The main glucocorticoids involved in the stress response are cortisol and cortisone in most mammals and corticosterone in birds and rodents. Therefore, these analytes are currently the biomarkers more frequently used to evaluate the physiological response to a stressful situation. In addition, “total glucocorticoids”, which refers to the quantification of various glucocorticoids by immunoassays showing cross-reactivity with different types of glucocorticoids or related metabolites, can be measured. In this review, we describe the characteristics of the main glucocorticoids used to assess stress, as well as the main techniques and samples used for their quantification. In addition, we analyse the studies where at least two of the main glucocorticoids were measured in combination. Overall, this review points out the different behaviours of the main glucocorticoids, depending on the animal species and stressful stimuli, and shows the potential advantages that the measurement of at least two different glucocorticoid types can have for evaluating welfare. Full article

(This article belongs to the Special Issue Metabolic and Endocrine Responses to Stress and Disease in Animal Production)

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Special Issue "Metabolic and Endocrine Responses to Stress and Disease in Animal Production"

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