Metabolomics in Human Tissues and Materials II

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (15 October 2021) | Viewed by 11248

Special Issue Editor


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Guest Editor
1. Beaumont Health, Royal Oak, MI 48073, USA
2. Oakland University-William Beaumont School of Medicine, Rochester Hills, MI 48309, USA
Interests: metabolomics; neurodegenerative disease; biomarkers; etiology; pathophysiology; integrating omics; epigenetics; proteomics
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Special Issue Information

Dear Colleagues,

Large-scale metabolomics studies that use human peripheral tissues to identify biomarkers for the early prediction and/or diagnosis of disease have become very appealing due to the number of metabolites that can now be accurately measured and identified. Further, metabolomics is being incorporated into many high-impact studies that focus on the etiopathophysiology of disease due to its innate ability to provide the most comprehensive insight into any given phenotype. Moreover, metabolomics is being increasingly used in the nutritional field to determine the effects of environmental pressures on the human “ome”. This list of applications is by no means comprehensive, and as such, this Special Issue is focused on (but not limited to) highlighting the use of metabolomics in studies that use human acquired specimens to do the following: (i) identify diagnostic and prognostic biomarkers of disease; (ii) study disease pathogenesis; (iii) conduct personalized/precision medicine; (iv) identify novel therapeutic targets; and (v) determine the effect of environmental exposure (including chemical and lifestyle exposures) on the human metabolome.

Prof. Dr. Stewart Graham
Guest Editor

Manuscript Submission Information

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Keywords

  • Biomarkers
  • Etiology
  • Pathophysiology
  • Nutrition
  • Precision medicine
  • Human specimens

Published Papers (1 paper)

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Research

15 pages, 2356 KiB  
Article
Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson’s Disease
by Peipei Li, Bryan A. Killinger, Elizabeth Ensink, Ian Beddows, Ali Yilmaz, Noah Lubben, Jared Lamp, Meghan Schilthuis, Irving E. Vega, Randy Woltjer, J. Andrew Pospisilik, Patrik Brundin, Lena Brundin, Stewart F. Graham and Viviane Labrie
Metabolites 2021, 11(1), 29; https://doi.org/10.3390/metabo11010029 - 4 Jan 2021
Cited by 68 | Viewed by 10767
Abstract
The gut microbiome can impact brain health and is altered in Parkinson’s disease (PD). The vermiform appendix is a lymphoid tissue in the cecum implicated in the storage and regulation of the gut microbiota. We sought to determine whether the appendix microbiome is [...] Read more.
The gut microbiome can impact brain health and is altered in Parkinson’s disease (PD). The vermiform appendix is a lymphoid tissue in the cecum implicated in the storage and regulation of the gut microbiota. We sought to determine whether the appendix microbiome is altered in PD and to analyze the biological consequences of the microbial alterations. We investigated the changes in the functional microbiota in the appendix of PD patients relative to controls (n = 12 PD, 16 C) by metatranscriptomic analysis. We found microbial dysbiosis affecting lipid metabolism, including an upregulation of bacteria responsible for secondary bile acid synthesis. We then quantitatively measure changes in bile acid abundance in PD relative to the controls in the appendix (n = 15 PD, 12 C) and ileum (n = 20 PD, 20 C). Bile acid analysis in the PD appendix reveals an increase in hydrophobic and secondary bile acids, deoxycholic acid (DCA) and lithocholic acid (LCA). Further proteomic and transcriptomic analysis in the appendix and ileum corroborated these findings, highlighting changes in the PD gut that are consistent with a disruption in bile acid control, including alterations in mediators of cholesterol homeostasis and lipid metabolism. Microbially derived toxic bile acids are heightened in PD, which suggests biliary abnormalities may play a role in PD pathogenesis. Full article
(This article belongs to the Special Issue Metabolomics in Human Tissues and Materials II)
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