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Metabolites
Special Issues
Veterinary Drug Residue Detection and Pharmacokinetics
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Veterinary Drug Residue Detection and Pharmacokinetics

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Pharmacology and Drug Metabolism".

Deadline for manuscript submissions: closed (20 January 2024) | Viewed by 2197

Special Issue Editors

Dr. Donghao Zhao

E-Mail Website
Guest Editor
Veterinary College, South China Agricultural University, Guangzhou, China
Interests: veterinary drug residue detection and pharmacokinetics
Dr. Dongping Zeng

E-Mail Website
Guest Editor
Veterinary College, South China Agricultural University, Guangzhou, China
Interests: pharmacokinetics
Prof. Dr. Fan Yang

E-Mail Website
Guest Editor
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Interests: aquaculture; pharmacokinetics; food safety
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The application of veterinary drugs is increasingly extensive with the rapid development of intensive aquaculture, which ensure the healthy and sustainable development of aquaculture. Meanwhile, the illegal use and irrational application of veterinary drugs are also generally common. Veterinary drug residue is the significant factor that affects safety of animal-derived food, such as toxicity, antimicrobial resistance, carcinogenesis, teratogenicity, mutagenicity, allergic reactions, environmental pollution, etc., which seriously hazard to human health. Many countries promulgated decrees or commands to prohibit the use of antibacterial agents as feed additives for food animal breeding. Therefore, it is of great significance to establish rapid, sensitive, and reliable detection methods to monitor the residues of veterinary drugs in animal food.

Qualitative analysis of veterinary drugs is a necessary means for pharmacokinetic research. As a discipline to study on the temporal change of drug concentration, it is extremely important to accurately detect the drug concentration in tissues and organs. This Special Issue of Metabolites will publish reviews and original articles covering the latest development of the study on veterinary drug residue detection and pharmacokinetics in livestock, poultry, aquatic animal, etc.

Dr. Donghao Zhao
Dr. Dongping Zeng
Prof. Dr. Fan Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacokinetics
  • pharmacokinetic/pharmacodynamic model
  • dose regimen design
  • residues of veterinary drug
  • edible animal tissues
  • aquatic product
  • determination methods
  • sample preparation technique

Published Papers (2 papers)

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Research

9 pages, 522 KiB  
Article
Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration
by Jun-Cheng Chen, Fang Yang, Guang-Hui Li, Ming-Hui Duan, Ze-En Li, Yan Dai, Mei Zhang and Fan Yang
Metabolites 2023, 13(8), 906; https://doi.org/10.3390/metabo13080906 - 02 Aug 2023
Cited by 1 | Viewed by 783
Abstract
This study aimed to determine the pharmacokinetics of danofloxacin in Gushi chickens after a single oral (PO) and intravenous (IV) dose at 5 mg/kg body weight (BW). Thirty-two Gushi chickens, aged 20 weeks, were selected and divided into two groups at random, with [...] Read more.
This study aimed to determine the pharmacokinetics of danofloxacin in Gushi chickens after a single oral (PO) and intravenous (IV) dose at 5 mg/kg body weight (BW). Thirty-two Gushi chickens, aged 20 weeks, were selected and divided into two groups at random, with each group consisting of 16 chickens, evenly distributed between males and females. Following danofloxacin administration, blood samples were taken at predetermined time intervals and the plasma was separated. The concentrations of danofloxacin in plasma were quantified by HPLC with a fluorescence detector. Then the concentrations versus time data were subjected to non-compartmental analysis (NCA) using Phoenix software (version: 8.1.0). After administering danofloxacin orally at a dose of 5 mg/kg BW to Gushi chickens, our results demonstrated that the peak concentration reached 0.53 μg/mL at 4 h. The half-life of absorption (t1/2ka) was determined to be 2.37 ± 1.60 h, and the bioavailability (F) was calculated as 40.12 ± 15.83%. For both oral and intravenous administration, the area under the concentration–time curve (AUC0-∞) was determined to be 4.72 ± 1.86 and 11.76 ± 3.25 h·µg/mL, respectively. The corresponding elimination half-life (t1/2λz) was measured as 11.24 ± 3.90 and 10.17 ± 3.72 h. Moreover, the mean residence time (MRT) was calculated as 10.20 ± 2.47 and 7.05 ± 1.97 h for these respective routes. Based on the calculated AUC/MIC ratio values, it can be inferred that the 5 mg/kg BW dosage of danofloxacin, whether administered orally or intravenously, is expected to effectively treat Escherichia coli and Pasteurella multocida infections in Gushi chickens. Full article
(This article belongs to the Special Issue Veterinary Drug Residue Detection and Pharmacokinetics)
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13 pages, 7444 KiB  
Article
Elimination of Cefquinome Sulfate Residue in Cow’s Milk after Intrauterine Infusion
by Chunshuang Liu, Mingyue Han, Honglei Wang, Xiaojie Chen, Yaoxin Tang, Daokang Zhang, Xiubo Li and Yiming Liu
Metabolites 2023, 13(4), 492; https://doi.org/10.3390/metabo13040492 - 29 Mar 2023
Viewed by 1043
Abstract
As set in the maximum residue limit regulations of the European Commission, this study aimed to obtain the residual parameters in milk with optimized UPLC-MS/MS conditions and to determine the conclusive drug withdrawal period to ensure food safety. In this research, an ultra-high [...] Read more.
As set in the maximum residue limit regulations of the European Commission, this study aimed to obtain the residual parameters in milk with optimized UPLC-MS/MS conditions and to determine the conclusive drug withdrawal period to ensure food safety. In this research, an ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed to study cefquinome sulfate’s residue elimination in milk and to calculate cefquinome’s withdrawal period. Twelve healthy cows free of endometritis were selected for the experiment. Before using the drug, the vaginal orifice and perineum of each cow was disinfected. One dose of intrauterine perfusion was used for each cow, followed by an additional dose after 72 h. Before administration and 12 h, 18 h, 24 h, 36 h, 42 h, 48 h, 60 h, 66 h, 72 h, 84 h, 90 h, and 96 h after the last dose, milk (10 mL) was gathered from each cow’s teat and pooled. For the measurement of cefquinome concentrations in milk, UPLC-MS/MS was performed. A calibration curve was generated using linear regression as follows: Y = 250.86X − 102.29, with a correlation coefficient of 0.9996; the limits of detection and the limits of quantitation were 0.1 μg·kg−1 and 0.2 μg·kg−1, respectively. The average recovery of cefquinome was 88.60 ± 16.33% at 0.2 μg·kg−1, 100.95 ± 2.54% at 10 μg·kg−1, and 97.29 ± 1.77% at 50 μg·kg−1. For 5 consecutive days at the three spiking levels, the intra and inter-day relative standard deviations (RSD) were 1.28%–13.73% and 1.81%–18.44%, respectively; the residual amount of cefquinome was less than the maximum residue limit of 20 μg·kg−1, 36 h after administration; and the residual amount was less than the limit of detection (0.1 μg·kg−1) 48 h after administration. The withdrawal time of cefquinome in cow’s milk was 39.8 h, as calculated using WTM1.4 software. In terms of clinical practical use, the withdrawal period of milk was temporarily set at 48 h after the administration of the cefquinome sulfate uterus injection to cows, in accordance with the recommended dose and course. Full article
(This article belongs to the Special Issue Veterinary Drug Residue Detection and Pharmacokinetics)
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