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Metabolites
Special Issues
Veterinary Drug Residue Detection and Pharmacokinetics
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Special Issue "Veterinary Drug Residue Detection and Pharmacokinetics"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Pharmacology and Drug Metabolism".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 506

Special Issue Editors

Dr. Donghao Zhao
E-Mail Website
Guest Editor
Veterinary College, South China Agricultural University, Guangzhou, China
Interests: veterinary drug residue detection and pharmacokinetics
Dr. Dongping Zeng

E-Mail Website
Guest Editor
Veterinary College, South China Agricultural University, Guangzhou, China
Interests: pharmacokinetics
Prof. Dr. Fan Yang

E-Mail Website
Guest Editor
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Interests: pharmacokinetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The application of veterinary drugs is increasingly extensive with the rapid development of intensive aquaculture, which ensure the healthy and sustainable development of aquaculture. Meanwhile, the illegal use and irrational application of veterinary drugs are also generally common. Veterinary drug residue is the significant factor that affects safety of animal-derived food, such as toxicity, antimicrobial resistance, carcinogenesis, teratogenicity, mutagenicity, allergic reactions, environmental pollution, etc., which seriously hazard to human health. Many countries promulgated decrees or commands to prohibit the use of antibacterial agents as feed additives for food animal breeding. Therefore, it is of great significance to establish rapid, sensitive, and reliable detection methods to monitor the residues of veterinary drugs in animal food.

Qualitative analysis of veterinary drugs is a necessary means for pharmacokinetic research. As a discipline to study on the temporal change of drug concentration, it is extremely important to accurately detect the drug concentration in tissues and organs. This Special Issue of Metabolites will publish reviews and original articles covering the latest development of the study on veterinary drug residue detection and pharmacokinetics in livestock, poultry, aquatic animal, etc.

Dr. Donghao Zhao
Dr. Dongping Zeng
Prof. Dr. Fan Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacokinetics
  • pharmacokinetic/pharmacodynamic model
  • dose regimen design
  • residues of veterinary drug
  • edible animal tissues
  • aquatic product
  • determination methods
  • sample preparation technique

Published Papers (1 paper)

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Research

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Article
Elimination of Cefquinome Sulfate Residue in Cow’s Milk after Intrauterine Infusion
by
Chunshuang Liu
,
Mingyue Han
,
Honglei Wang
,
Xiaojie Chen
,
Yaoxin Tang
,
Daokang Zhang
,
Xiubo Li
and
Yiming Liu
Metabolites 2023, 13(4), 492; https://doi.org/10.3390/metabo13040492 - 29 Mar 2023
Viewed by 332
Abstract
As set in the maximum residue limit regulations of the European Commission, this study aimed to obtain the residual parameters in milk with optimized UPLC-MS/MS conditions and to determine the conclusive drug withdrawal period to ensure food safety. In this research, an ultra-high [...] Read more.
As set in the maximum residue limit regulations of the European Commission, this study aimed to obtain the residual parameters in milk with optimized UPLC-MS/MS conditions and to determine the conclusive drug withdrawal period to ensure food safety. In this research, an ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed to study cefquinome sulfate’s residue elimination in milk and to calculate cefquinome’s withdrawal period. Twelve healthy cows free of endometritis were selected for the experiment. Before using the drug, the vaginal orifice and perineum of each cow was disinfected. One dose of intrauterine perfusion was used for each cow, followed by an additional dose after 72 h. Before administration and 12 h, 18 h, 24 h, 36 h, 42 h, 48 h, 60 h, 66 h, 72 h, 84 h, 90 h, and 96 h after the last dose, milk (10 mL) was gathered from each cow’s teat and pooled. For the measurement of cefquinome concentrations in milk, UPLC-MS/MS was performed. A calibration curve was generated using linear regression as follows: Y = 250.86X − 102.29, with a correlation coefficient of 0.9996; the limits of detection and the limits of quantitation were 0.1 μg·kg−1 and 0.2 μg·kg−1, respectively. The average recovery of cefquinome was 88.60 ± 16.33% at 0.2 μg·kg−1, 100.95 ± 2.54% at 10 μg·kg−1, and 97.29 ± 1.77% at 50 μg·kg−1. For 5 consecutive days at the three spiking levels, the intra and inter-day relative standard deviations (RSD) were 1.28%–13.73% and 1.81%–18.44%, respectively; the residual amount of cefquinome was less than the maximum residue limit of 20 μg·kg−1, 36 h after administration; and the residual amount was less than the limit of detection (0.1 μg·kg−1) 48 h after administration. The withdrawal time of cefquinome in cow’s milk was 39.8 h, as calculated using WTM1.4 software. In terms of clinical practical use, the withdrawal period of milk was temporarily set at 48 h after the administration of the cefquinome sulfate uterus injection to cows, in accordance with the recommended dose and course. Full article
(This article belongs to the Special Issue Veterinary Drug Residue Detection and Pharmacokinetics)
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