Metabolic Changes and Epigenetic Alterations
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2386
Special Issue Editors
Interests: epigenetics; metabolism; type 2 diabetes; gastrointestinal tumors; obesity
Interests: epigenetics; stem cells (including cancer stem cells); gene expression; molecular mechanisms of tumorigenesis; transcription factors; chromatin remodelling enzymes; post-translational modifications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The link between metabolism and epigenetics has been established for many years. Remarkably, it has been demonstrated that metabolites might work as a cofactor of specific epigenetic enzymes regulating their function and, consequently, cell transcriptomic landscape. Of note, metabolic rewiring and alterations are typical of different pathophysiological conditions including aging, cancer, chronic, and degenerative diseases. These epi-metabolite fluctuations affecting the cell epigenome might contribute to the onset and progression of the above-mentioned pathophysiological conditions. In this light, the discovery of the so-called “nuclear metabolic niches” confirmed the strict physical interaction between mitochondria, the main source of metabolites, and nuclei where the epi-metabolic exchange occurs. There, metabolic enzymes directly provide metabolites to epigenetic enzymes located at the chromatin. Moreover, recent advances in OMIC technologies and integrative analysis have helped to shed light on a set of novel epi-metabolic interactions underlying human diseases. The present issue has been designed with the goal to collect recent and original data pointing out the special link between metabolism and epigenetics in different pathophysiological contexts.
Dr. Francesco Spallotta
Dr. Barbara Illi
Guest Editors
Manuscript Submission Information
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Keywords
- metabolism
- epigenetic enzymes
- metabolic syndrome
- cancer
- aging
- metabolic rewiring
- chronic diseases
- chromatin
