Special Issue "Plant Metabolites: Therapeutics, Toxicology, and Pharmacology"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Plant Metabolism".

Deadline for manuscript submissions: 15 June 2023 | Viewed by 1171

Special Issue Editors

Department of Biotechnology, East West First Grade College, Bengaluru, Karnataka, India
Interests: biomedicine; secondary metabolite production; plant biotechnology
School of Allied Health Sciences, REVA University, Bangalore 560064, India
Interests: natural products; flavonoids; anticancer; tissue engineering; immunology; toxicology; bioremediation; nanotechnology; animal cell culture; preclinical studies on animal models and molecular biology
Toxicity and Risk Assessment Division, Department of Agro-Food Safety and Crop Protection, National Institute of Agricultural Sciences, Rural Development Administration, Wanju-gun 55365, Republic of Korea
Interests: cancer; transcriptome; toxicology

Special Issue Information

Dear Colleagues,

Plant metabolites are active chemical compounds derived naturally from primary plant metabolic pathways. Such phytochemicals are not essential for plant growth and propagation but possess a vital role in plant interaction with biotic and abiotic factors of their ecosystem. In the present era of phytopharmaceutical product development, there is a tremendous increase in the use of phytochemicals. These metabolites can be grouped based on their chemical structure that includes phenolic compounds, organic acids, glucosinolates, cyanogenic glucosides, amines, non-protein amino acids, peptides, alkaloids, and terpenes. Metabolites are commercially interesting, and they are currently exploited in several fields, such as in the production of ordinary food, novel food, cosmetics, agrochemicals, fine chemicals, biopharmaceuticals, and nutraceuticals. Several studies on plant metabolites have revealed their applications in antibacterial, antifungal, chemopreventive, anti-inflammatory, antidiabetic, anti-angiogenic activities, etc. and have made researchers focus more on plant-derived drug developments to fight against malignant disorders. As key compounds in diet, they can promote healthy life with their antioxidative properties. Despite the availability of synthetic medicine for these diseases, however, the chemicals used in them come with various side effects.

In this Special Issue, in addition to review articles, we invite original articles that deal with ideas related to plant-derived products with antibacterial, anticancerous, antifungal and any other properties, as well as novel toxicological studies and preclinical trials on different flavonoids.

Dr. Mallappa Kumara Swamy
Dr. Natesan Karthi
Dr. Bala Murali Krishna Vasamsetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • metabolites
  • flavonoids
  • antibacterial
  • antifungal
  • anticancer
  • toxicity
  • pharmaceutical activity
  • transcriptome

Published Papers (1 paper)

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Analysis of Floral Scent and Volatile Profiles of Different Aster Species by E-nose and HS-SPME-GC-MS
Metabolites 2023, 13(4), 503; https://doi.org/10.3390/metabo13040503 - 31 Mar 2023
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Plants from the Aster species are known to be a rich source of bioactive chemical compositions and are popularly known for their medicinal properties. To investigate the relationship between the nine species of Aster, the floral fragrance and volatile profile patterns were [...] Read more.
Plants from the Aster species are known to be a rich source of bioactive chemical compositions and are popularly known for their medicinal properties. To investigate the relationship between the nine species of Aster, the floral fragrance and volatile profile patterns were characterized using E-nose and HS-SPME-GC-MS. Initial optimization for fragrance analysis was performed with Aster yomena using E-nose by evaluating the scent patterns in different flowering stages. Aster yomena exhibited varied scent patterns in each flowering stage, with the highest relative aroma intensity (RAI) in the full flowering stage. PCA analysis to compare and analyze the scent characteristics of nine Aster species, showed a species-specific classification. HS-SPME-GC-MS analysis of flowers from nine Aster species revealed 52 volatile compounds including β-myrcene, α-phellandrene, D-limonene, trans-β-ocimene, caryophyllene, and β-cadinene. The terpenoid compounds accounted for the largest proportion. Among the nine Aster species flowers, Aster koraiensis had sesquiterpenes as the major component, and the remaining eight varieties had monoterpenes in abundance. These results could distinguish the species according to the scent patterns and volatile components of the nine Aster species. Additionally, flower extracts from the Aster species’ plants exhibited radical scavenging antioxidant activity. Among them, it was confirmed that Aster pseudoglehnii, Aster maackii, and Aster arenarius had high antioxidant activity. In conclusion, the results of this study provide fundamental data of the volatile compound properties and antioxidant activity of Aster species, offering basic information of valuable natural sources that can be utilized in the pharmaceutical, perfume, and cosmetic industries. Full article
(This article belongs to the Special Issue Plant Metabolites: Therapeutics, Toxicology, and Pharmacology)
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