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Membranes
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Biocompatible Membrane Materials
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Biocompatible Membrane Materials

A special issue of Membranes (ISSN 2077-0375). This special issue belongs to the section "Membrane Applications".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 6866

Special Issue Editors

Dr. Marcin Wekwejt

E-Mail Website
Guest Editor
1. Biomaterials Division, Faculty of Mechanical Engineering and Ship Technology, Gdańsk University of Technology, G. Narutowicza 11/12, 80-233 Gdańsk, Poland
2. Laboratory for Biomaterials and Bioengineering (CRC-Tier I), Dept Min-Met-Materials Eng & Regenerative Medicine, CHU de Quebec, Laval University, 10 Rue de l'Espinay, Quebec City, QC G1L 3L5, Canada
Interests: biomaterials; antibacterial properties; cytocompatibility; nanometals; implants; bone cements; spacers; biopolymers; bioceramics
Special Issues, Collections and Topics in MDPI journals
Dr. Beata Kaczmarek

E-Mail Website
Guest Editor
Department of Biomaterials and Cosmetic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Torun, Poland
Interests: natural polymers; tissue engineering; biocompatible coatings; thin films; polymers crosslinking; biomaterials properties
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are very pleased to invite you to submit your work to this Special Issue concerning biocompatible membrane materials. Recently, membranes become extremely interesting materials, which may be characterized by different properties and find a variety of applications, also as biomaterials. Over the past decades, many researchers have been working intensively to obtain fully biocompatible and bioactive or biofunctional membranes, which after implantation into the human body could support tissue regeneration or even treat various diseases. The search for novel biocompatible materials and techniques for obtaining them seems to be the key to the development of bioeffective membranes. This Special Issue aims to gather experienced researchers, materials engineers, chemists, biotechnologists, pharmacists, and medics interested in biomaterials areas linked mainly to biomembranes. Modern trends in their fabrication and the study of their physicochemical, mechanical, as well as biological properties are highlighted and will be discussed in detail. Original research articles, short communications, and reviews are kindly welcome. Potential topics include (but are not limited to) the following:

  • Preparation of biocompatible membranes.
  • Characterization and analysis of membrane structure.
  • Assessment of the properties of biomembranes.
  • Novel composite membrane materials.
  • Natural/synthetic polymeric membranes.
  • Biomembranes for tissue regeneration.
  • Bioactive membranes for supporting the treatment of diseases.
  • Antibacterial membranes for bacterial infections treatment.
  • Biocompatibility evaluation of membrane materials.
  • Bioresorbable/biodegradable membranes.
  • Smart biofuction membranes.

We look forward to receiving your contributions.

Dr. Marcin Wekwejt
Dr. Beata Kaczmarek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

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Research

13 pages, 4295 KiB  
Article
Evaluation between Biodegradable Magnesium Metal GBR Membrane and Bovine Graft with or without Hyaluronate
by Marko Blašković, Dorotea Blašković, David Botond Hangyasi, Olga Cvijanović Peloza, Matej Tomas, Marija Čandrlić, Patrick Rider, Berit Mang, Željka Perić Kačarević and Branko Trajkovski
Membranes 2023, 13(8), 691; https://doi.org/10.3390/membranes13080691 - 25 Jul 2023
Cited by 3 | Viewed by 1400
Abstract
Bone substitutes and barrier membranes are widely used in dental regeneration procedures. New materials are constantly being developed to provide the most optimal surgical outcomes. One of these developments is the addition of hyaluronate (HA) to the bovine bone graft, which has beneficial [...] Read more.
Bone substitutes and barrier membranes are widely used in dental regeneration procedures. New materials are constantly being developed to provide the most optimal surgical outcomes. One of these developments is the addition of hyaluronate (HA) to the bovine bone graft, which has beneficial wound healing and handling properties. However, an acidic environment that is potentially produced by the HA is known to increase the degradation of magnesium metal. The aim of this study was to evaluate the potential risk for the addition of HA to the bovine bone graft on the degradation rate and hence the efficacy of a new biodegradable magnesium metal GBR membrane. pH and conductivity measurements were made in vitro for samples placed in phosphate-buffered solutions. These in vitro tests showed that the combination of the bovine graft with HA resulted in an alkaline environment for the concentrations that were used. The combination was also tested in a clinical setting. The use of the magnesium metal membrane in combination with the tested grafting materials achieved successful treatment in these patients and no adverse effects were observed in vivo for regenerative treatments with or without HA. Magnesium based biodegradable GBR membranes can be safely used in combination with bovine graft with or without hyaluronate. Full article
(This article belongs to the Special Issue Biocompatible Membrane Materials)
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17 pages, 5191 KiB  
Article
Chitosan-Based Membranes as Gentamicin Carriers for Biomedical Applications—Influence of Chitosan Molecular Weight
by Milena Supernak, Balbina Makurat-Kasprolewicz, Beata Kaczmarek-Szczepańska, Anna Pałubicka, Monika Sakowicz-Burkiewicz, Anna Ronowska and Marcin Wekwejt
Membranes 2023, 13(6), 542; https://doi.org/10.3390/membranes13060542 - 23 May 2023
Cited by 2 | Viewed by 1298
Abstract
Over the past decade, much attention has been paid to chitosan as a potential drug carrier because of its non-toxicity, biocompatibility, biodegradability and antibacterial properties. The effect of various chitosan characteristics on its ability to carry different antibiotics is discussed in the literature. [...] Read more.
Over the past decade, much attention has been paid to chitosan as a potential drug carrier because of its non-toxicity, biocompatibility, biodegradability and antibacterial properties. The effect of various chitosan characteristics on its ability to carry different antibiotics is discussed in the literature. In this work, we evaluated the influence of the different molecular weights of this polymer on its potential as an antibacterial membrane after adding gentamicin (1% w/w). Three types of chitosan membranes without and with antibiotic were prepared using a solvent casting process. Their microstructures were analyzed with a 4K digital microscope, and their chemical bonds were studied using FTIR spectroscopy. Furthermore, cytocompatibility on human osteoblasts and fibroblasts as well as antibacterial activity against Staphylococcus aureus (S. aureus.) and Escherichia coli (E. coli) were assessed. We observed that the membrane prepared from medium-molecular-weight chitosan exhibited the highest contact angle (≈85°) and roughness (10.96 ± 0.21 µm) values, and its antibacterial activity was unfavorable. The maximum tensile strength and Young’s modulus of membranes improved and elongation decreased with an increase in the molecular weight of chitosan. Membranes prepared with high-molecular-weight chitosan possessed the best antibacterial activity, but mainly against S. aureus. For E. coli, is not advisable to add gentamicin to the chitosan membrane, or it is suggested to deplete its content. None of the fabricated membranes exhibited a full cytotoxic effect on osteoblastic and fibroblast cells. Based on our results, the most favorable membrane as a gentamicin carrier was obtained from high-molecular-weight chitosan. Full article
(This article belongs to the Special Issue Biocompatible Membrane Materials)
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17 pages, 2642 KiB  
Article
Dual Crosslinked Ion-Based Bacterial Cellulose Composite Hydrogel Containing Polyhexamethylene Biguanide
by Baramee Chanabodeechalermrung, Tanpong Chaiwarit, Sarana Rose Sommano, Pornchai Rachtanapun, Nutthapong Kantrong, Chuda Chittasupho and Pensak Jantrawut
Membranes 2022, 12(9), 825; https://doi.org/10.3390/membranes12090825 - 24 Aug 2022
Cited by 9 | Viewed by 1956
Abstract
Composite bacterial cellulose (BC) based hydrogel with alginate (A) or pectin (P) or alginate and pectin was fabricated via a physical crosslinking technique using calcium chloride (CaCl2) solution and incorporated with polyhexamethylene biguanide (PHMB) as an effective antimicrobial drug by immersion [...] Read more.
Composite bacterial cellulose (BC) based hydrogel with alginate (A) or pectin (P) or alginate and pectin was fabricated via a physical crosslinking technique using calcium chloride (CaCl2) solution and incorporated with polyhexamethylene biguanide (PHMB) as an effective antimicrobial drug by immersion method. After that, the physicochemical properties of all hydrogel formulations were characterized. The result showed that the formulations with PHMB performed better physicochemical properties than the hydrogel without PHMB. Fourier transform infrared spectroscopy (FT-IR) showed the interaction between PHMB and the carboxylic group of alginate and pectin. BC/A-PHMB hydrogel performed suitable mechanical strength, fluid uptake ability, water retention property, drug content, high integrity value, and maximum swelling degree. Moreover, in vitro cell viability of BC/A-PHMB hydrogel revealed high biocompatibility with human keratinocyte cell line (HaCaT) and demonstrated prolong released of PHMB in Tris-HCl buffer pH 7.4, while rapid release in phosphate buffer saline pH 7.4. BC/A-PHMB hydrogel demonstrated good anti-bacterial activity against S. aureus and P. aeruginosa. In conclusion, BC/A-PHMB hydrogel could be a potential dual crosslinked ion-based hydrogel for wound dressing with anti-bacterial activity. Full article
(This article belongs to the Special Issue Biocompatible Membrane Materials)
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12 pages, 1952 KiB  
Article
In Vitro Evaluation of the Permeability of Different Resorbable Xenogeneic Membranes after Collagenolytic Degradation
by Ramona Kölliker, Stefan P. Hicklin, Constanze Hirsiger, Chun Ching Liu, Fredi Janett and Patrick R. Schmidlin
Membranes 2022, 12(8), 787; https://doi.org/10.3390/membranes12080787 - 17 Aug 2022
Cited by 1 | Viewed by 1397
Abstract
In this in vitro study, we compare the penetration of cells through different resorbable collagen membranes, which were collagenolytically degraded over different time periods. Three different resorbable collagen membranes were evaluated, including two non-cross-linked (NCL) membranes—namely, a porcine (NCL-P) and an equine (NCL-E) [...] Read more.
In this in vitro study, we compare the penetration of cells through different resorbable collagen membranes, which were collagenolytically degraded over different time periods. Three different resorbable collagen membranes were evaluated, including two non-cross-linked (NCL) membranes—namely, a porcine (NCL-P) and an equine (NCL-E) membrane—and an enzymatically cross-linked porcine (ECL-B) membrane. A special two-chamber model was fabricated, allowing for the placement of separating membranes, and a non-porous polyester membrane was used as a negative control (C), in order to verify the impermeability of the experimental chamber device. Round membrane samples with a diameter of 16 mm were fabricated. Eighteen membranes of each type were punched and placed on polyethylene nets as carriers. The membranes were then biodegraded—each on its carrier—in 12-well polystyrene plates: three samples of each membrane type were degraded for 1.5, 3, 6, or 12 h in 2 mL of a buffered collagenase solution, at 37 °C. For control purposes, three samples of each membrane type were not degraded, but only immersed in buffer solution for 1.5, 3, 6, or 12 h, at 37 °C. Another three samples of each type of membrane were degraded until complete dissolution, in order to determine the full hydroxyproline content for comparison. Liquid-preserved boar semen (containing at least 120 million sperm cells per milliliter) was used to test the cell occlusivity of the degraded membranes. At baseline and initial degradation, all tested membranes were tight, and no penetration was observed with up to 30 min of incubation time (results not shown). After 1.5 h, cells were partially capable of penetrating the NCL-E membrane only. One sample showed leakage, with a sperm volume of 1.7 million cells/mL over all samples. No penetration occurred in the test, NCL-P, and ECL-B groups. After a degradation time of 3 h, the NCL-P and ECL-B membranes remained occlusive to cells. All the membranes and measurements indicated leakage in the NCL-E group. After 6 h, four NCL-P measurements showed the first signs of cell penetration, as boar spermatozoa were detectable in the lower chamber (64 million cells/mL). The ECL-B membranes remained completely cell occlusive. After 12 h, four NCL-P measurements were cell penetration positive (14.6 million cells/mL), while the ECL-B group remained tight and showed no cell penetration. As the findings of our study are well in accordance with the results of several previous animal studies, it can be concluded that the surrogate model is capable of performing rapid and cheap screening of cell occlusivity for different collagen membranes in a very standardized manner. In particular, claims of long degradation resistance can be easily proven and compared. As the boar spermatozoa used in the present report had a size of 9 × 5 μm, smaller bacteria are probably also able to penetrate the leaking membranes; in this regard, our proposed study set-up may provide valuable information, although it must be acknowledged that sperm cells show active mobility and do not only translocate by growth. Full article
(This article belongs to the Special Issue Biocompatible Membrane Materials)
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