Anticoagulant Therapies in Particular Clinical Conditions

A special issue of Medicina (ISSN 1648-9144).

Deadline for manuscript submissions: closed (20 November 2021) | Viewed by 2398

Special Issue Editors


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Guest Editor
1. Hemostasis and Thrombosis Departmental Unit, University of Cagliari, 09124 Cagliari, Italy
2. SHRO, Temple University, Philadelphia, PA 19122, USA
Interests: thrombosis; hemostasis; anticoagulant therapies; hereditary and acquired thrombophilia

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Guest Editor
Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy
Interests: thrombosis; hemostasis; anticoagulant therapies; hereditary and acquired thrombophilia

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Guest Editor
Thrombosis and Haemostasis Centre, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Govanni Rotondo, Italy
Interests: women's issues; thrombotic disease; hemorrhagic disease; pregnancy issues; transfusion complications

Special Issue Information

Dear Colleagues,

The daily clinical use of heparins, vitamin K antagonists, and direct oral anticoagulants in the management of difficult clinical situations such as assisted reproductive technologies, antiphospholipid syndrome, SARS-CoV-2 infection, renal failure, venous thrombosis in unusual sites, and isolated distal deep vein thrombosis is often challenging. What is needed is to give helpful suggestions in managing such patients from a practical point of view, even when there are no so clear evidence-based recommendations about treatment.

It is well known that both in- and outpatients often show clinical characteristics and comorbidities that have been excluded from all randomized clinical trials, but despite this, such patients need a final therapeutic decision.

This Special Issue of Medicina onAnticoagulant Therapies in particular clinical conditions”, showing gray areas of the topics cited above, has the aim to help doctors in their daily clinical practice.

Dr. Doris Barcellona
Prof. Francesco Marongiu
Dr. Elvira Grandone
Guest Editors

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Keywords

  • antivitamin-k antagonists
  • direct oral anticoagulants
  • assisted reproductive technologies
  • antiphospholipid syndrome
  • SARS-COV 2 and thrombosis
  • renal failure
  • venous thrombosis in unusual site
  • distal deep vein thrombosis

Published Papers (1 paper)

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4 pages, 557 KiB  
Case Report
Could DOAC Be a Better Choice Than Warfarin in Low Compliance Patients with Fontan Procedure?
by Jisoo Park, Bo-Young Hong, Joon-Sung Kim, Jung-Geun Park, Jiyoon Jung and Seong-Hoon Lim
Medicina 2021, 57(5), 465; https://doi.org/10.3390/medicina57050465 - 10 May 2021
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Abstract
Background and Objectives: After the Fontan procedure, thromboembolic events need to be prevented. We present a young patient with a history of Fontan procedure and poor adherence to warfarin who developed systemic thromboembolism. He was changed to maintenance dabigatran, which is one of [...] Read more.
Background and Objectives: After the Fontan procedure, thromboembolic events need to be prevented. We present a young patient with a history of Fontan procedure and poor adherence to warfarin who developed systemic thromboembolism. He was changed to maintenance dabigatran, which is one of the available direct oral anticoagulants (DOACs). Case presentation: A 20-year-old man was diagnosed with cerebral infarct, pulmonary thromboembolism (PTE), and renal infarcts. He was prescribed warfarin to prevent thromboembolic events after the Fontan procedure. Based on his poor adherence to warfarin, we decided to change the anticoagulant therapy from warfarin to dabigatran 150 mg bid. One month later, his pulmonary thromboembolism regressed. Conclusion: Our case report showed a young adult with low compliance to warfarin who developed cerebral, pulmonary, and renal thromboembolic events. Thus, in our opinion, the change from warfarin to a DOAC was necessary for further prevention and treatment of PTE. A change from warfarin to a DOAC should be considered in patients with poor compliance who are at high risk of thromboembolic events, for example, after the Fontan procedure. Full article
(This article belongs to the Special Issue Anticoagulant Therapies in Particular Clinical Conditions)
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