Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.6
2.6
Journals
Medicina
Special Issues
Molecular Mechanisms, Diagnosis, and Therapy of Thyroid Diseases
share announcement

Molecular Mechanisms, Diagnosis, and Therapy of Thyroid Diseases

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Endocrinology".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 2144

Special Issue Editors

Prof. Dr. Valerio D'Orazi

E-Mail Website
Guest Editor
Department of Surgical Sciences, Sapienza University of Rome, 00161 Rome, Italy
Interests: microsurgery in thyroid surgery; hand surgery and peripheral nerve injury and neoplasms; andrological microsurgery
Dr. Gabriella D’Orazi

E-Mail Website
Guest Editor
1. Department of Neuroscience and Imaging, University G. D’Annunzio, 66013 Chieti, Italy
2. Department of Research, Unit of Cellular Network and Therapeutic Innovation, Regina Elena National Cancer Institute, 00144 Rome, Italy
Interests: tumor biology; molecular oncology; onco-suppressor p53; autophagy; hypoxia; oxidative stress; tumor microenvironment; glioblastoma; personalized medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to provide an update on recent advances in the understanding of thyroid pathology and the implications in clinical practice and new surgical approaches to thyroid diseases.

Advances in surgery allow expanded surgical treatment options and potentially make thyroid cancer surgery safer and better accepted by patients. No surgical approach is without its concomitant risks in thyroid surgery; this includes injury to recurrent laryngeal nerves and hypoparathyroidism. One of the purposes of this Special Issue is to stimulate discussion about improvements in surgical techniques to avoid or limit these complications, including microsurgical and endoscopic thyroidectomy techniques and the use of operative adjuncts in thyroid surgery, such as loupes magnification, intraoperative neuromonitoring, and indocyanine green. Clinical studies which better analyze the use of this new technology and its relative benefits and risks are particularly welcome.

Advances in genomics have offered exciting insights into the biology of thyroid cancer. While much attention has been focused on traditional nucleic acids, the study of proteins and their function has been relatively neglected, in part due to the difficulty of the techniques required.

We hope that this Special Issue will educate, stimulate, and inspire support for participation in clinical trials and new research in the field of thyroid cancer and benign thyroid disease.

The development of new surgical approaches, effective targeted therapies, new biomarkers, and better preventive interventions will assist in improving treatment and outcome in patients with thyroid diseases.

Prof. Dr. Valerio D'Orazi
Dr. Gabriella D’Orazi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • surgical innovations
  • diagnostic techniques
  • hypocalcemia
  • recurrent laryngeal nerve injury
  • thyroid cancer
  • molecular markers
  • immunotherapy
  • targeted therapy
  • tumor heterogeneity

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

11 pages, 4872 KiB  
Article
Intraoperative Neuromonitoring and Optical Magnification in the Prevention of Recurrent Laryngeal Nerve Injuries during Total Thyroidectomy
by Menelaos Karpathiotakis, Valerio D’Orazi, Andrea Ortensi, Andrea Biancucci, Rossella Melcarne, Maria Carola Borcea, Chiara Scorziello and Francesco Tartaglia
Medicina 2022, 58(11), 1560; https://doi.org/10.3390/medicina58111560 - 30 Oct 2022
Cited by 3 | Viewed by 1591
Abstract
Background and Objectives: Recurrent laryngeal nerve (RLN) paralysis is a fearful complication during thyroidectomy. Intraoperative neuromonitoring (IONM) and optical magnification (OM) facilitate RLN identification and dissection. The purpose of our study was to evaluate the influence of the two techniques on the [...] Read more.
Background and Objectives: Recurrent laryngeal nerve (RLN) paralysis is a fearful complication during thyroidectomy. Intraoperative neuromonitoring (IONM) and optical magnification (OM) facilitate RLN identification and dissection. The purpose of our study was to evaluate the influence of the two techniques on the incidence of RLN paralysis and determine correlations regarding common outcomes in thyroid surgery. Materials and Methods: Two equally sized groups of 50 patients who underwent total thyroidectomies were examined. In the first group (OM), only surgical binocular loupes (2.5×–4.5×) were used during surgery, while in the second group (IONM), the intermittent NIM was applied. Results: Both the operative time and the length of hospitalization were shorter in the OM group than in the IONM group (median 80 versus 100 min and median 2 versus 4 days, respectively) (p < 0.05). The male patients were found to have a five-fold higher risk of developing transient dysphonia than the females (adjusted OR 5.19, 95% IC 0.99–27.18, p = 0.05). The OM group reported a four-fold higher risk of developing transient hypocalcemia than the IONM group (OR 3.78, adjusted OR 4.11, p = 0.01). Despite two cases of temporary bilateral RLN paralysis in the IONM group versus none in the OM group, no statistically significant difference was found (p > 0.05). No permanent RLN paralysis or hypoparathyroidism have been reported. Conclusions: Despite some limitations, our study is the first to compare the use of IONM with OM alone in the prevention of RLN injuries. The risk of recurrent complications remains comparable and both techniques can be considered valid instruments, especially if applied simultaneously by surgeons. Full article
(This article belongs to the Special Issue Molecular Mechanisms, Diagnosis, and Therapy of Thyroid Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop