Minimally Invasive and Fertility-Sparing Treatment of Gynecological Cancers

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Obstetrics and Gynecology".

Deadline for manuscript submissions: closed (1 April 2021) | Viewed by 2942

Special Issue Editors

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Guest Editor
Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, University of Genova, 16132 Genoa, Italy
Interests: endometriosis; adenomyosis; gynecological ultrasound; gynecological imaging; reproductive surgery; uterine myomas; uterine malformation; ultrasound
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Special Issue Information

Dear Colleagues,

The need to provide curative but less-morbid therapeutic options for women affected by gynecological cancers has been appreciated in recent years, with a relevant increase in the number of studies focused on the potential benefits and risks of minimally invasive fertility-sparing surgical procedures.

The objective of fertility-sparing treatment in patients affected by gynecological cancers is to guarantee adequate reproductive function while maintaining a low risk of long-term disease recurrence. The management of patients wishing to maintain fertility is complex and requires adequate counselling from a multidisciplinary team; working closely and engaging in discussion with fertility specialists is a prerequisite if women are to be given the best chance of obtaining a successful future pregnancy.

Currently, there are several key factors influencing the recommendation for fertility-sparing surgery, and the preoperative planning of these surgical procedures should be based on the optimal selection of patients with an accurate preoperative examination. Oncologic and obstetric outcomes related to the specific type of surgical approach and the necessity of adjuvant medical options should be assessed.

There are several approaches for fertility preservation in cervical cancer, such as cervical conization or radical trachelectomy. Uterine-sparing options such as hormonal therapy (in primis progestins) may be considered for women with early-stage, low-grade endometrial cancer. Ovarian borderline tumors tend to be diagnosed more commonly in younger women, and for this reason can often be treated with conservative surgery. Fertility-sparing surgery in combination with comprehensive surgical staging may be performed in selected young patients with invasive ovarian cancer and apparent disease confined to one ovary.

This Special Issue shall welcome contributions of original articles as well as narrative and systematic reviews, with or without meta-analysis. Overall, this Issue aims to provide summaries of the current evidence, in addition to new developing discoveries and future directions in the field of the minimally invasive and fertility-sparing treatment of gynecological cancers.

Prof. Dr. Simone Ferrero
Dr. Fabio Barra
Guest Editors

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  • Fertility-sparing surgery
  • Endometrial cancer
  • Cervical cancer
  • Ovarian cancer
  • Conization
  • Trachelectomy
  • Sentinel lymph node
  • Progestins
  • Oophorectomy

Published Papers (1 paper)

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7 pages, 4861 KiB  
Case Report
Advanced Ovarian Cancer during Pregnancy. Tumour Evolution Analysis and Treatment Approach
by Ana Isabel Bueno Moral, Jose Carlos Vilches Jiménez, Adriana Serrano Olave, María Pilar Espejo Reina, María Estrella Valdivia de Dios and Jesús S. Jiménez López
Medicina 2021, 57(5), 426; - 28 Apr 2021
Cited by 1 | Viewed by 2035
Background: The possible presence of malignant adnexal mass should be considered during pregnancy. For this reason, it is important to keep in mind such possibility while performing routine obstetric ultrasounds to diagnose asymptomatic ovarian cancer in the early stages. Case presentation: 27-year-old pregnant [...] Read more.
Background: The possible presence of malignant adnexal mass should be considered during pregnancy. For this reason, it is important to keep in mind such possibility while performing routine obstetric ultrasounds to diagnose asymptomatic ovarian cancer in the early stages. Case presentation: 27-year-old pregnant patient with a known adnexal tumour occurring at week 20 and enlarged supraclavicular lymph nodes of 3 cm size who was diagnosed with metastases from low-grade papillary serous ovarian carcinoma. The patient, obstetricians, neonatologists and oncologists agreed on initiating neoadjuvant chemotherapy and performing an elective C-section at week 34. She gave birth to a female infant weighing 2040 g who is currently in good health, and continues receiving follow-up care by a medical oncologist. Conclusions. An early diagnosis of gynaecologic malignancies during pregnancy is of critical importance because, although they are very rare, managing and treating carcinomas at an early stage allow us to increase maternal and fetal well-being and to offer more alternatives to our patients. Full article
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