Dear Colleagues,

Obesity and adiposity, along with their associated metabolic complications, are steadily growing globally and have become a major concern for public health. However, obesity is a broad spectrum engulfing several adiposity phenotypes; each carries distinct related risks and metabolic implications. The obesity epidemic is a key promotor, growing in importance, of cardiovascular diseases, the most substantial cause of morbidity and mortality worldwide.

Adiposity phenotypes are associated with specific hormonal alterations mainly related to a complex crosstalk between distinct fat depots, the gut, the liver, and the brain. Adipose tissue is one of the most active endocrine organs of the human body. It affects not only insulin resistance but also sex hormones metabolism and levels, gut hormones secretion, systemic inflammation, and central functions such as satiety, hunger, mood disorders, and reward system activity. The endocrine system, on its different axes, has considerable implications on cardiovascular health, and its adiposity-related alterations might have a detrimental or positive influence on cardiovascular health. However, the complex interplay between adiposity, the endocrine system, and cardiovascular health is not fully understood.

Also, the potential hormonal-targeted interventions to affect obesity-related cardiometabolic health is an area of growing focus, where the scientific community has just scratched the surface. In this special issue, we aim to focus on unique phenotypes and mechanisms of adiposity-related hormonal adaptations and their influence on cardiometabolic health. We also aim to address potential lifestyle, recreational, and pharmacological interventions that might benefit adiposity-related cardiovascular complications via targeting endocrine axes.

Dr. Gal Tsaban
Dr. Anat Yaskolka Meir
Guest Editors

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• adiposity
• metabolic syndrome
• insulin resistance
• hormones
• obesity
• cardiovascular diseases
• lifestyle intervention
• pharmacologic interventions
• ectopic fat
• gut-fat-brain axis