Hip and Fragility Fracture Management

A special issue of Medicina (ISSN 1648-9144).

Deadline for manuscript submissions: closed (1 October 2021) | Viewed by 54401

Special Issue Editor


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Guest Editor
1. Medical Faculty, University of Zurich, Zurich, Switzerland
2. RWTH Aachen University Hospital, Aachen, Germany
Interests: anchorage strategies in geriatric hip fracture management; fragility fracture; fall prevention; ortho-geriatric co-management; geriatric trauma center; medical education; biomechanical investigations; microcirculation
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Special Issue Information

Dear Colleagues,

Geriatric trauma care is gaining more importance due to demographic changes. This growth in geriatric trauma patients presents a great challenge for the treating physicians. In addition to poor bone quality, which makes (operative) fracture fixation more difficult, comorbid conditions often lead to perioperative complications and hamper rehabilitation. Considering all these factors, geriatric trauma has great social and economic implications.

Surgical treatment should be straightforward and less invasive, allow immediate weight-bearing, and should be associated with a low complication rate. Various factors, such as patient age, comorbidities, activity level, age of the fracture or pre-injury arthrosis, and experience of the surgeon influence the decision-making for fixation. To reduce mechanical complications in the osteosynthesis of proximal femoral fractures, improved fixation techniques have been developed including blade or screw-anchor devices, locked minimally invasive or cement augmentation strategies. However, despite numerous innovations and advances regarding implant design and surgical techniques, systemic and mechanical complication rates remain high. Treatment success depends on secure implant fixation as well as on patient-specific factors (fracture stability, bone quality, comorbidity, and gender) and surgeon-related factors (experience, correct reduction, and optimal screw placement). Fracture reduction and implant positioning are directly related, with correct reduction being the prerequisite to correct implant placement. However, in recent years, cement augmentation strategies came to the fore and were discussed to an increasing degree.

The 1-month mortality rate after hip fracture ranges from 4% to 12% and reaches up to 35% after 1 year. The hip fracture patient frequently presents with complex comorbidities, including but not limited to impaired hepatic and renal function, diabetes mellitus, dementia, delirium, coronary artery disease, heart failure, and patient polypharmacy. These are all individually linked to an increase in postoperative complications and mortality. Hip fractures create substantial needs for informal caregiving and postacute and long-term care that carry major costs to society.

However, the incidence of falls in the elderly population is difficult to determine, and therefore potentially underestimated. Previous falls, strength, gait and balance impairments, and use of specific medications range amongst the strongest predictors. Indication from the literature suggests that older adults tend not to be sufficiently aware of their potential for falls or their fall risk. In addition, the literature suggests that client outcomes vary with the type of treatment prescribed, the equipment of the clinic, and the health professional’s abilities.

The purpose of this Special Issue is to discuss the evidence for the fixation/prosthetic treatment of femoral neck fractures, as well as trochanteric and subtrochanteric fractures in elderly patients. The scope of the Issue is deliberately broad in order to encourage the coverage of a wide range of topics and perspectives related to the management of hip fractures. This includes not only clinical treatments but also biomechanical considerations regarding implant anchorage, patient experience, epidemiology, service delivery, health promotion, complex co-management strategies in geriatric fracture care including fall prevention, and new interdisciplinary developments like the installation of a fracture liaison service or a geriatric fracture center.

Prof. Dr. Matthias Knobe
Guest Editor

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Keywords

  • hip fracture
  • fracture fixation
  • implant anchorage
  • cement augmentation
  • co-management
  • fragility fracture
  • comorbidity
  • fall prevention
  • biomechanical investigation
  • geriatric fracture center

Published Papers (17 papers)

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7 pages, 1806 KiB  
Article
Minimally Invasive Approaching in Hip Surgery—An Anatomical Investigation of 20 Specimens
by Clemens Schopper, Hannes Traxler, Bernhard Schauer, Günter Hipmair, Tobias Gotterbarm and Matthias Luger
Medicina 2021, 57(11), 1283; https://doi.org/10.3390/medicina57111283 - 22 Nov 2021
Cited by 1 | Viewed by 1419
Abstract
Background and objectives: Based on the preparation of 20 formalin-fixed anatomical cadavers, the feasibility of the anterior, minimally invasive approach to the hip joint was investigated in each side of the body. The hypothesis of the study was that the Lateral Femoral [...] Read more.
Background and objectives: Based on the preparation of 20 formalin-fixed anatomical cadavers, the feasibility of the anterior, minimally invasive approach to the hip joint was investigated in each side of the body. The hypothesis of the study was that the Lateral Femoral Cutaneous Nerve can be spared under the use of this approach. Materials and Methods: The anterior approach to the hip was performed via an incision of 8 cm. The position of the nerve was noticed in relation to the skin incision, and the distance was measured in millimeters. The nerves main, gluteal and femoral trunk were distinguished and investigated for injury. Results: No injury of the main trunk was noticed. The average distance of the main trunk to the skin incision was 14.9 and 15.05 mm in the medial direction, respectively (p < 0.001). Injury of the gluteal branch has to be considered at an overall rate of 40%. Conclusions: The anterior, minimally invasive approach to the hip joint can be performed without injury of the Lateral Femoral Cutaneous Nerve. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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11 pages, 632 KiB  
Article
In-Hospital Clinical Outcomes in Patients with Fragility Fractures of the Lumbar Spine, Thoracic Spine, and Pelvic Ring: A Comparison of Data before and after Certification as a DGU® Geriatric Trauma Centre
by Markus Laubach, Laura Christine Gruchow, Tobias Hafner, Filippo Migliorini, Matthias Knobe, Frank Hildebrand and Miguel Pishnamaz
Medicina 2021, 57(11), 1197; https://doi.org/10.3390/medicina57111197 - 03 Nov 2021
Cited by 5 | Viewed by 1688
Abstract
Background and Objectives: The implementation of orthogeriatric co-management (OGCM) reflects the demand for interdisciplinary collaborations due to the increasing comorbidities of geriatric trauma patients. This study aimed to assess clinical in-hospital outcomes in lumbar spine, thoracic spine, and pelvic ring fragility fracture [...] Read more.
Background and Objectives: The implementation of orthogeriatric co-management (OGCM) reflects the demand for interdisciplinary collaborations due to the increasing comorbidities of geriatric trauma patients. This study aimed to assess clinical in-hospital outcomes in lumbar spine, thoracic spine, and pelvic ring fragility fracture patients before and after the implementation of a Geriatric Trauma Centre (GTC) certified by the German Trauma Society (DGU®). Materials and Methods: In this observational, retrospective cohort study, geriatric trauma patients (>70 years of age) were stratified into either a pre-GTC group (hospital admission between 1 January 2012 and 31 December 2013) or a post-GTC group (hospital admission between 1 January 2017 and 31 December 2018). Patients’ pre-injury medical complexity was measured by ASA class (American Society of Anaesthesiologists classification), the use of anticoagulant medication, and the ACCI (Age-adjusted Charlson Comorbidity Index). Outcome parameters were patients’ in-hospital length of stay (LOS) and mortality rates, as well as new in-hospital findings and diagnoses. Further, the necessity of deviation from initial management plans due to complications was assessed using the Adapted Clavien–Dindo Scoring System in Trauma (ACDiT score of ≥1). Results: Patients in the post-GTC group (n = 111) were older (median age 82.0 years) compared to the pre-GTC group (n = 108, median age 80.0 years, p = 0.016). No differences were found in sex, body mass index, ASA class, or ACCI (all p > 0.05). Patients in the post-GTC group used vitamin K antagonists or direct oral anticoagulants more frequently (21.3% versus 10.8%). The incidence of non-surgical treatment and mortality was comparable between groups, while LOS tended to be shorter in the post-GTC group (7.0 days versus 9.0 days, p = 0.076). In the post-GTC group, the detection of urinary tract infections (UTI) increased (35.2% versus 16.2%, p = 0.001), and the delirium diagnoses tended to increase (13.0% versus 6.3%, p = 0.094), while an ACDiT score of ≥1 was comparable between groups (p = 0.169). Conclusions: In this study including lumbar spine, thoracic spine, and pelvic ring geriatric fragility fractures, patients in the post-GTC group were more medically complex. More UTIs and the tendency for increased delirium detection was observed in the post-GTC group, likely due to improved diagnostic testing. Nonetheless, the necessity of deviation from initial management plans (ACDiT score of ≥1) was comparable between groups, potentially a positive result of OGCM. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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10 pages, 3020 KiB  
Article
Impact of Bone Cement Augmentation on the Fixation Strength of TFNA Blades and Screws
by An Sermon, Ladina Hofmann-Fliri, Ivan Zderic, Yash Agarwal, Simon Scherrer, André Weber, Martin Altmann, Matthias Knobe, Markus Windolf and Boyko Gueorguiev
Medicina 2021, 57(9), 899; https://doi.org/10.3390/medicina57090899 - 28 Aug 2021
Cited by 9 | Viewed by 2819
Abstract
Background and Objectives: Hip fractures constitute the most debilitating complication of osteoporosis with steadily increasing incidences in the aging population. Their intramedullary nailing can be challenging because of poor anchorage in the osteoporotic femoral head. Cement augmentation of Proximal Femoral Nail Antirotation (PFNA) [...] Read more.
Background and Objectives: Hip fractures constitute the most debilitating complication of osteoporosis with steadily increasing incidences in the aging population. Their intramedullary nailing can be challenging because of poor anchorage in the osteoporotic femoral head. Cement augmentation of Proximal Femoral Nail Antirotation (PFNA) blades demonstrated promising results by enhancing cut-out resistance in proximal femoral fractures. The aim of this study was to assess the impact of augmentation on the fixation strength of TFN-ADVANCEDTM Proximal Femoral Nailing System (TFNA) blades and screws within the femoral head and compare its effect when they are implanted in centre or anteroposterior off-centre position. Materials and Methods: Eight groups were formed out of 96 polyurethane low-density foam specimens simulating isolated femoral heads with poor bone quality. The specimens in each group were implanted with either non-augmented or cement-augmented TFNA blades or screws in centre or anteroposterior off-centre positions, 7 mm anterior or posterior. Mechanical testing was performed under progressively increasing cyclic loading until failure, in setup simulating an unstable pertrochanteric fracture with a lack of posteromedial support and load sharing at the fracture gap. Varus-valgus and head rotation angles were monitored. A varus collapse of 5° or 10° head rotation was defined as a clinically relevant failure. Results: Failure load (N) for specimens with augmented TFNA head elements (screw/blade centre: 3799 ± 326/3228 ± 478; screw/blade off-centre: 2680 ± 182/2591 ± 244) was significantly higher compared with respective non-augmented specimens (screw/blade centre: 1593 ± 120/1489 ± 41; screw/blade off-centre: 515 ± 73/1018 ± 48), p < 0.001. For both non-augmented and augmented specimens failure load in the centre position was significantly higher compared with the respective off-centre positions, regardless of the head element type, p < 0.001. Augmented off-centre TFNA head elements had significantly higher failure load compared with non-augmented centrally placed implants, p < 0.001. Conclusions: Cement augmentation clearly enhances the fixation stability of TFNA blades and screws. Non-augmented blades outperformed screws in the anteroposterior off-centre position. Positioning of TFNA blades in the femoral head is more forgiving than TFNA screws in terms of failure load. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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11 pages, 510 KiB  
Article
The Management between Comorbidities and Pain Level with Physical Activity in Individuals with Hip Osteoarthritis with Surgical Indication: A Cross-Sectional Study
by Michael Silveira Santiago, Felipe J. Aidar, Talita Leite dos Santos Moraes, Jader Pereira de Farias Neto, Mário Costa Vieira Filho, Diego Protásio de Vasconcelos, Victor Siqueira Leite, Felipe Meireles Doria, Erick Sobral Porto, Reuthemann Esequias Teixeira Tenório Albuquerque Madruga, David Edson Ramos de Azevedo, Adonai Pinheiro Barreto, Marcel Vieira Gomes, Paulo Francisco de Almeida-Neto, Breno Guilherme de Araújo Tinôco Cabral and Walderi Monteiro da Silva Júnior
Medicina 2021, 57(9), 890; https://doi.org/10.3390/medicina57090890 - 27 Aug 2021
Cited by 3 | Viewed by 1726
Abstract
Background and Objectives: The degenerative pathology of the hip joint appears in young age groups, related to fem-oroacetabular impingement, and in advanced age, due to other inflammatory causes, with greater potential for severity in the presence of comorbidities. Objectives: To evaluate [...] Read more.
Background and Objectives: The degenerative pathology of the hip joint appears in young age groups, related to fem-oroacetabular impingement, and in advanced age, due to other inflammatory causes, with greater potential for severity in the presence of comorbidities. Objectives: To evaluate the participation of the main causes of osteoarthritis in relation to physical activities, s Body Mass Index (BMI) and television time (TV). Materials and Methods: 54 patients with surgical indication treated at an orthopedic referral university hospital were stratified into groups (Impact: I, Osteonecrosis/rheumatic: II, Infectious/traumatic: III), and the influence of comorbidities on physical activity performance, relative to BMI and TV time. Results: It was observed that the impact group was the most frequent (51.8%), with 79.6% under the age of 60 years. This group followed the general mean (p < 0.05), using the variables of comorbidity and the level of physical activity. Pain intensity, TV time, BMI showed no correlation with physical activity. Conclusion: Morphostructural changes (group I) represented the most frequent etiological group, and severe pain was common in almost the entire sample. Unlike BMI, comorbidity showed a significant relationship with the level of physical activity. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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8 pages, 1440 KiB  
Article
Trochanteric Femur Fractures: Application of Skeletal Traction during Surgery Does Not Alter Soft-Tissue Microcirculation
by Kenneth P. van Knegsel, Bergita Ganse, Pascal C. Haefeli, Filippo Migliorini, Mario F. Scaglioni, Bryan J. M. van de Wall, Bong-Sung Kim, Björn-Christian Link, Frank J. P. Beeres, Sven Nebelung, Carsten Schoeneberg, Frank Hildebrand, Boyko Gueorguiev and Matthias Knobe
Medicina 2021, 57(9), 884; https://doi.org/10.3390/medicina57090884 - 27 Aug 2021
Cited by 4 | Viewed by 7290
Abstract
Background and Objectives: Wound infections provoked by alterations in microcirculation are major complications in the treatment of trochanteric femur fractures. Surgical fracture fixation on a traction table is the gold standard for treatment, but the effect on tissue microcirculation is unknown. Microcirculation [...] Read more.
Background and Objectives: Wound infections provoked by alterations in microcirculation are major complications in the treatment of trochanteric femur fractures. Surgical fracture fixation on a traction table is the gold standard for treatment, but the effect on tissue microcirculation is unknown. Microcirculation could be impaired by the pull on the soft-tissue or by a release of vasoactive factors. We hypothesized that intraoperative traction impairs soft-tissue microcirculation. Materials and Methods: In 22 patients (14 women, eight men), average age 78 years (range 36–96 ± 14), with trochanteric femur fractures, non-invasive laser-Doppler spectrophotometry was used to assess oxygen saturation, hemoglobin content, and blood flow in the skin and subcutaneous tissue before and after application of traction. Measurements were recorded in nine locations around the greater trochanter at a depth of 2, 8, and 15 mm before and after fracture reduction by traction. Results: No differences were found in any depth with traction compared to without (oxygen saturation: p = 0.751, p = 0.308, and p = 0.955, haemoglobin content: p = 0.651, p = 0.928, and p = 0.926, blood flow: p = 0.829, p = 0.866, and p = 0.411). Conclusion: In this pilot study, the application of traction does not affect skin and subcutaneous microcirculation in the surgery of proximal femur fractures. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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12 pages, 332 KiB  
Article
Care of Geriatric Patients with Lumbar Spine, Pelvic, and Acetabular Fractures before and after Certification as a Geriatric Trauma Center DGU®: A Retrospective Cohort Study
by Tobias Hafner, Alina Kollmeier, Markus Laubach, Matthias Knobe, Frank Hildebrand and Miguel Pishnamaz
Medicina 2021, 57(8), 794; https://doi.org/10.3390/medicina57080794 - 31 Jul 2021
Cited by 7 | Viewed by 1851
Abstract
Background: More than 750,000 fragility fractures occur in Germany every year, with an expected increase in the following years. Interdisciplinary care pathways for geriatric patients are increasingly established to improve the treatment process and outcome, but there has been only limited evaluation of [...] Read more.
Background: More than 750,000 fragility fractures occur in Germany every year, with an expected increase in the following years. Interdisciplinary care pathways for geriatric patients are increasingly established to improve the treatment process and outcome, but there has been only limited evaluation of their use. Objectives: This study aimed to compare patient care before and after the implementation of a geriatric trauma center (GTC) in conformity with the German Society for Trauma Surgery (DGU®). Patients and Methods: We performed a retrospective single-center cohort study, including 361 patients >70 years old with lumbar spine, pelvic, and acetabular fractures, admitted between January 2012 and September 2019. Patients were divided into a usual care cohort (UC, n = 137) before implementation and an ortho-geriatric care cohort (OGC, n = 224) after implementation of the GTC DGU®. We recorded and compared demographic data, fracture type, geriatric assessment and management, therapy, complications, and various clinical parameters, e.g., length of stay, time to surgery, hours admitted to ICU, and change in walking ability. Results: The geriatric assessment revealed significant geriatric co-morbidities and a need for geriatric intervention in 75% of the patients. With orthogeriatric co-management, a significant increase in the detection of urological complications (UC: 25.5% vs. OGC: 37.5%; p = 0.021), earlier postoperative mobilization (UC: 57.1% vs. OGC: 86.3%; p < 0.001), an increased prescription of anti-osteoporotic treatment at discharge (UC: 13.1% vs. OGC: 46.8%; p < 0.001), and lower rates of revision surgery (UC: 5.8% vs. OGC: 3.1%; p = 0.012) could be seen. Conclusions: Our results emphasize the improvement in patient care and clinical outcome by implementing a GTC DGU® and provide opportunities for future improvement in ortho-geriatric patient care. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
9 pages, 1399 KiB  
Article
Postoperative Morbidity and Complications in Elderly Patients after Harvesting of Iliac Crest Bone Grafts
by Marie Sophie Katz, Mark Ooms, Marius Heitzer, Florian Peters, Philipp Winnand, Kristian Kniha, Stephan Christian Möhlhenrich, Frank Hölzle, Matthias Knobe and Ali Modabber
Medicina 2021, 57(8), 759; https://doi.org/10.3390/medicina57080759 - 27 Jul 2021
Cited by 13 | Viewed by 4046
Abstract
Background and objectives: In oral and maxillofacial operations, the iliac crest is a commonly used donor site from which to harvest bone for augmentation prior to dental implantation or for reconstruction of jaw defects caused by trauma or pathological lesions. In an [...] Read more.
Background and objectives: In oral and maxillofacial operations, the iliac crest is a commonly used donor site from which to harvest bone for augmentation prior to dental implantation or for reconstruction of jaw defects caused by trauma or pathological lesions. In an aging society, the proportion of elderly patients undergoing iliac crest bone grafting for oral augmentation is growing. Although postoperative morbidity is usually moderate to low, the age and health of the patient should be considered as risk factors for complications and delayed mobilization after the operation. The aim of this retrospective study was to evaluate the postoperative morbidity and complications in elderly patients after the harvesting of iliac crest bone grafts for oral surgery. Material and Methods: Data were collected from a total of 486 patients (aged 7–85) who had a surgical procedure that included the harvesting of iliac crest bone grafts for intraoral transplantation. All patients were operated on between 2005 and 2021 in the Department for Oral and Maxillofacial Surgery of the University Hospital in Aachen, Germany. As parameters for postoperative morbidity and complications, gait disturbances, hypesthesia of cutaneous nerves, incision hernias, iliac crest fractures, delayed wound healing, and unfavorable scar formation at the donor site were all evaluated. Results: The study was performed with 485 patients due to the exclusion of one patient as the only one from whom grafts were taken from both sides. When younger and older patients were compared, neither gait disturbances (p = 0.420), nor hernias (p = 0.239), nor fractures (p = 0.239), nor hypesthesia (p = 0.297), nor wound healing delay (p = 0.294), nor scar problems (p = 0.586) were significantly different. However, the volume of the graft was significantly correlated with the duration of the hospital stay (ρ = 0.30; p < 0.01) but not with gait disturbances (ρ = 0.60; p = 0.597). Additionally, when controlling for age (p = 0.841), sex (p = 0.031), ASA class (p = 0.699), preexisting orthopedic handicaps (p = 0.9828), and the volume of the bone graft (p = 0.770), only male sex was associated with the likelihood of suffering gait disturbances (p = 0.031). Conclusions: In conclusion, harvesting bone grafts from the anterior iliac crest for intraoral augmentation is a safe procedure for both young and elderly patients. Although there is some postoperative morbidity, such as gait disturbances, hypesthesia, scar formation, or delayed wound healing at the donor site, rates for these minor complications are low and mostly of short duration. Major complications, such as fractures or incision hernias, are very rare. However, in our study, the volume of the bone graft was associated with a longer stay in hospital, and this should be considered in the planning of iliac crest bone graft procedures. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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10 pages, 602 KiB  
Article
Open Reduction in Subtrochanteric Femur Fractures Is Not Accompanied by a Higher Rate of Complications
by Tom Knauf, Daphne Eschbach, Benjamin Buecking, Matthias Knobe, Juliane Barthel, Katherine Rascher, Steffen Ruchholtz, Rene Aigner, Carsten Schoeneberg and on behalf of the Registry for German Trauma DGU
Medicina 2021, 57(7), 659; https://doi.org/10.3390/medicina57070659 - 27 Jun 2021
Cited by 4 | Viewed by 1800
Abstract
Backgroundand Objectives: Hip fractures are among the most typical geriatric fractures. Subtrochanteric fractures are considered difficult to treat, and, to date, there is no consensus on the optimal surgical treatment. Materialisand Methods: We analyzed data from the Registry for [...] Read more.
Backgroundand Objectives: Hip fractures are among the most typical geriatric fractures. Subtrochanteric fractures are considered difficult to treat, and, to date, there is no consensus on the optimal surgical treatment. Materialisand Methods: We analyzed data from the Registry for Geriatric Trauma, which includes patients ≥ 70 years old with hip fractures or periprosthetic fractures requiring surgery (21,734 patients in 2017–2019). For this study, we analyzed only the subgroup of patients with a subtrochanteric fracture. We analyzed the difference between closed and open surgical methods on a range of outcomes, including mortality, mobility, length of acute hospital stay, and the need for surgical revisions. Results: A total of 506 patients with subtrochanteric fractures were analyzed in this study. The median age was 85 years (interquartile range of 81–89). About 21.1% (n = 107) were operated on with a closed technique, 73.3% (n = 371) with open reduction without using a cerclage, and 5.53% (n = 28) with open reduction with the additional use of one or more cerclage wires. A total of 3.56% (n = 18) of the patients had complications requiring operative revision, most commonly soft tissue interventions (open vs. closed reduction—3.26% vs. 4.67%) (p = 0.687). Patients treated with open reduction were significantly more mobile 7 days after surgery (p = 0.008), while no significant effects on mortality (p = 0.312), length of hospital stay (p = 0.968), or surgical complications (p = 0.687) were found. Conclusion: Proper reduction is the gold standard practice for successful union in subtrochanteric fractures. This study shows that open reduction is not associated with a higher complication rate but does lead to increased mobility 7 days after operation. Therefore, in case of doubt, a good reduction should be aimed for, even using open techniques. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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13 pages, 1872 KiB  
Article
A Bibliometric Analysis of Fragility Fractures: Top 50
by Nicolas Vuillemin, Hans-Christoph Pape, Pol Maria Rommens, Kurt Lippuner, Klaus-Arno Siebenrock, Marius Johann Keel and Johannes Dominik Bastian
Medicina 2021, 57(6), 639; https://doi.org/10.3390/medicina57060639 - 21 Jun 2021
Cited by 9 | Viewed by 2401
Abstract
Background and Objectives: The population is aging and fragility fractures are a research topic of steadily growing importance. Therefore, a systematic bibliometric review was performed to identify the 50 most cited articles in the field of fragility fractures analyzing their qualities and [...] Read more.
Background and Objectives: The population is aging and fragility fractures are a research topic of steadily growing importance. Therefore, a systematic bibliometric review was performed to identify the 50 most cited articles in the field of fragility fractures analyzing their qualities and characteristics. Materials and Methods: From the Core Collection database in the Thomson Reuters Web of Knowledge, the most influential original articles with reference to fragility fractures were identified in February 2021 using a multistep approach. Year of publication, total number of citations, average number of citations per year since year of publication, affiliation of first and senior author, geographic origin of study population, keywords, and level of evidence were of interest. Results: Articles were published in 26 different journals between 1997 and 2020. The number of total citations per article ranged from 12 to 129 citations. In the majority of publications, orthopedic surgeons and traumatologists (66%) accounted for the first authorship, articles mostly originated from Europe (58%) and the keyword mostly used was “hip fracture”. In total, 38% of the articles were therapeutic studies level III followed by prognostic studies level I. Only two therapeutic studies with level I could be identified. Conclusions: This bibliometric review shows the growing interest in fragility fractures and raises awareness that more high quality and interdisciplinary studies are needed. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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12 pages, 666 KiB  
Article
Fear of Falling, Recurrence of Falls, and Quality of Life in Patients with a Low Energy Fracture—Part II of an Observational Study
by Puck C. R. van der Vet, Jip Q. Kusen, Manuela Rohner-Spengler, Björn-Christian Link, Roderick M. Houwert, Matthias Knobe, Reto Babst, Christoph Henzen, Lukas Schmid and Frank J. P. Beeres
Medicina 2021, 57(6), 584; https://doi.org/10.3390/medicina57060584 - 07 Jun 2021
Cited by 6 | Viewed by 1891
Abstract
Background and objective: Falls in elderly cause injury, mortality, and loss of independence, making Fear of Falling (FoF) a common health problem. FoF relates to activity restriction and increased fall risk. A voluntary intervention including fall risk assessment and prevention strategies was [...] Read more.
Background and objective: Falls in elderly cause injury, mortality, and loss of independence, making Fear of Falling (FoF) a common health problem. FoF relates to activity restriction and increased fall risk. A voluntary intervention including fall risk assessment and prevention strategies was implemented to reduce falls in elderly patients with low energy fractures (LEF). The primary purpose of this study was to evaluate FoF and the number of subsequent falls in trauma patients one year after a LEF. The secondary aim was to examine how FoF affects patients’ lives in terms of Quality of Life (QoL), mobility, and activity levels. Finally, participation in the voluntary fall prevention program (FPP) was evaluated. Materials and Methods: Observational cohort study in one Swiss trauma center. LEF patients, treated between 2012 and 2015, were analyzed one year after injury. Primary outcomes were Falls-Efficacy Score-International (FES-I) and number of subsequent falls. Secondary outcomes were EuroQoL-5-Dimensions-3-Levels (EQ5D-3L), mobility, activity levels, and participation in the FPP. Subgroup analysis was performed for different age categories. Results: 411 patients were included for analysis. Mean age was 72 ± 9.3, mean FES-I was 21.1 ± 7.7. Forty percent experienced FoF. A significant negative correlation between FoF and QoL (R = 0.64; p < 0.001) was found. High FoF correlated with lower activity levels (R= −0.288; p < 0.001). Six percent visited the FPP. Conclusions: At follow-up, 40% suffered from FoF which seems to negatively affect patients’ QoL. Nevertheless, participation in the FPP was low. Simply informing patients about their susceptibility to falls and recommending participation in FPPs seems insufficient to motivate and recruit patients into FPPs. We suggest implementing repeated fall risk- and FoF screenings as standard procedures in the follow-up of LEF, especially in patients aged over 75 years. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
12 pages, 1045 KiB  
Article
Early Surgery Does Not Improve Outcomes for Patients with Periprosthetic Femoral Fractures—Results from the Registry for Geriatric Trauma of the German Trauma Society
by Christopher Bliemel, Katherine Rascher, Tom Knauf, Juliana Hack, Daphne Asimenia Eschbach, Rene Aigner, Ludwig Oberkircher and on behalf of the AltersTraumaRegister DGU
Medicina 2021, 57(6), 517; https://doi.org/10.3390/medicina57060517 - 21 May 2021
Cited by 6 | Viewed by 2009
Abstract
Background and Objectives: Appropriate timing of surgery for periprosthetic femoral fractures (PFFs) in geriatric patients remains unclear. Data from a large international geriatric trauma register were analyzed to examine the outcome of patients with PFF with respect to the timing of surgical stabilization. [...] Read more.
Background and Objectives: Appropriate timing of surgery for periprosthetic femoral fractures (PFFs) in geriatric patients remains unclear. Data from a large international geriatric trauma register were analyzed to examine the outcome of patients with PFF with respect to the timing of surgical stabilization. Materials and Methods: The Registry for Geriatric Trauma of the German Trauma Society (Deutsche Gesellschaft für Unfallchirurgie (DGU)) (ATR-DGU) was analyzed. Patients treated surgically for PFF were included in this analysis. As outcome parameters, in-house mortality rate and mortality at the 120-day follow-up as well as mobility, the EQ5D index score and reoperation rate were analyzed in relation to early (<48 h) or delayed (≥48 h) surgical stabilization. Results: A total of 1178 datasets met the inclusion criteria; 665 fractures were treated with osteosynthesis (56.4%), and 513 fractures were treated by implant change (43.5%). In contrast to the osteosynthesis group, the group with implant changes underwent delayed surgical treatment more often. Multivariate logistic regression analysis of mortality rate (p = 0.310), walking ability (p = 0.239) and EQ5D index after seven days (p = 0.812) revealed no significant differences between early (<48 h) and delayed (≥48 h) surgical stabilization. These items remained insignificant at the follow-up as well. However, the odds of requiring a reoperation within 120 days were significantly higher for delayed surgical treatment (OR: 1.86; p = 0.003). Conclusions: Early surgical treatment did not lead to decreased mortality rates in the acute phase or in the midterm. Except for the rate of reoperation, all other outcome parameters remained unaffected. Nevertheless, for most patients, early surgical treatment should be the goal, so as to achieve early mobilization and avoid secondary nonsurgical complications. If early stabilization is not possible, it can be assumed that orthogeriatric co-management will help protect these patients from further harm. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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15 pages, 4080 KiB  
Article
Medial Calcar Comminution and Intramedullary Nail Failure in Unstable Geriatric Trochanteric Hip Fractures
by Seth M. Tarrant, David Graan, Drew J. Tarrant, Raymond G. Kim and Zsolt J. Balogh
Medicina 2021, 57(4), 338; https://doi.org/10.3390/medicina57040338 - 01 Apr 2021
Cited by 2 | Viewed by 3162
Abstract
Background and Objectives: An increasing global burden of geriatric hip fractures is anticipated. The appropriate treatment for fractures is of ongoing interest and becoming more relevant with an aging population and finite health resources. Trochanteric fractures constitute approximately half of all hip [...] Read more.
Background and Objectives: An increasing global burden of geriatric hip fractures is anticipated. The appropriate treatment for fractures is of ongoing interest and becoming more relevant with an aging population and finite health resources. Trochanteric fractures constitute approximately half of all hip fractures with the medial calcar critical to fracture stability. In the management of unstable trochanteric fractures, it is assumed that intramedullary nails and longer implants will lead to less failure. However, the lack of power, inclusion of older generation femoral nails, and a variable definition of stability complicate interpretation of the literature. Materials and Methods: Between January 2012 and December 2017, a retrospective analysis of operatively treated geriatric trochanteric hip fracture patients were examined at a Level 1 Trauma Centre. The treatment was with a long and short version of one type of trochanteric nail. Unstable trochanteric fractures with medial calcar comminution were examined (AO31A2.3, 2.3 & 3.3). The length of the medial calcar loss, nail length, demographics, fracture morphology, and relevant technical factors were examined in univariate and multivariate analysis using competing risk regression analysis. The primary outcome was failure of fixation with post-operative death the competing event and powered to previously reported failure rates. Results: Unstable patterns with medial calcar comminution loss constituted 617 (56%) of operatively treated trochanteric fractures. Failure occurred in 16 (2.6%) at a median post-operative time of 111 days (40–413). In univariate and multivariate analysis, only younger age was a significant predictor of failure (years; SHR: 0.91, CI 95%: 0.86–0.96, p < 0.001). Nail length, medial calcar loss, varus reduction, and other technical factors did not influence nail failure. Conclusions: In a cohort of unstable geriatric trochanteric hip fractures with medial calcar insufficiency, only younger patient age was predictive of nail failure. Neither the length of the medial calcar fragment or nail was predictive of failure. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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9 pages, 2296 KiB  
Article
Age-Dependent Patient and Trauma Characteristics and Hospital Resource Requirements—Can Improvement Be Made? An Analysis from the German Trauma Registry
by Franziska Ziegenhain, Julian Scherer, Yannik Kalbas, Valentin Neuhaus, Rolf Lefering, Michel Teuben, Kai Sprengel, Hans-Christoph Pape, Kai Oliver Jensen and The TraumaRegister DGU
Medicina 2021, 57(4), 330; https://doi.org/10.3390/medicina57040330 - 01 Apr 2021
Cited by 7 | Viewed by 2006
Abstract
Background and objectives: The burden of geriatric trauma patients continues to rise in Western society. Injury patterns and outcomes differ from those seen in younger adults. Getting a better understanding of these differences helps medical staff to provide a better care for the [...] Read more.
Background and objectives: The burden of geriatric trauma patients continues to rise in Western society. Injury patterns and outcomes differ from those seen in younger adults. Getting a better understanding of these differences helps medical staff to provide a better care for the elderly. The aim of this study was to determine epidemiological differences between geriatric trauma patients and their younger counterparts. To do so, we used data of polytraumatized patients from the TraumaRegister DGU®. Materials and Methods: All adult patients that were admitted between 1 January 2013 and 31 December 2017 were included from the TraumaRegister DGU®. Patients aged 55 and above were defined as the elderly patient group. Patients aged 18–54 were included as control group. Patient and trauma characteristics, as well as treatment and outcome were compared between groups. Results: A total of 114,169 severely injured trauma patients were included, of whom 55,404 were considered as elderly patients and 58,765 younger patients were selected for group 2. Older patients were more likely to be admitted to a Level II or III trauma center. Older age was associated with a higher occurrence of low energy trauma and isolated traumatic brain injury. More restricted utilization of CT-imaging at admission was observed in older patients. While the mean Injury Severity Score (ISS) throughout the age groups stayed consistent, mortality rates increased with age: the overall mortality in young trauma patients was 7.0%, and a mortality rate of 40.2% was found in patients >90 years of age. Conclusions: This study shows that geriatric trauma patients are more frequently injured due to low energy trauma, and more often diagnosed with isolated craniocerebral injuries than younger patients. Furthermore, utilization of diagnostic tools as well as outcome differ between both groups. Given the aging society in Western Europe, upcoming studies should focus on the right application of resources and optimizing trauma care for the geriatric trauma patient. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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Review

Jump to: Research, Other

9 pages, 329 KiB  
Review
Fragility Fractures: Risk Factors and Management in the Elderly
by Filippo Migliorini, Riccardo Giorgino, Frank Hildebrand, Filippo Spiezia, Giuseppe Maria Peretti, Mario Alessandri-Bonetti, Jörg Eschweiler and Nicola Maffulli
Medicina 2021, 57(10), 1119; https://doi.org/10.3390/medicina57101119 - 17 Oct 2021
Cited by 62 | Viewed by 3573
Abstract
Given the progressive ageing of Western populations, the fragility fractures market has a growing socioeconomic impact. Fragility fractures are common in the elderly, negatively impacting their quality of life, limiting autonomy, increasing disability, and decreasing life expectancy. Different causes contribute to the development [...] Read more.
Given the progressive ageing of Western populations, the fragility fractures market has a growing socioeconomic impact. Fragility fractures are common in the elderly, negatively impacting their quality of life, limiting autonomy, increasing disability, and decreasing life expectancy. Different causes contribute to the development of a fractures in frail individuals. Among all, targeting fragile patients before the development of a fracture may represent the greatest challenge, and current diagnostic tools suffer from limitations. This study summarizes the current evidence on the management of fragility fractures, discussing risk factors, prevention, diagnosis, and actual limitations of the clinical therapeutic options, putting forward new ideas for further scientific investigation. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
9 pages, 622 KiB  
Review
Intracapsular Femoral Neck Fractures—A Surgical Management Algorithm
by James W. A. Fletcher, Christoph Sommer, Henrik Eckardt, Matthias Knobe, Boyko Gueorguiev and Karl Stoffel
Medicina 2021, 57(8), 791; https://doi.org/10.3390/medicina57080791 - 31 Jul 2021
Cited by 9 | Viewed by 6397
Abstract
Background and Objectives: Femoral neck fractures are common and constitute one of the largest healthcare burdens of the modern age. Fractures within the joint capsule (intracapsular) provide a specific surgical challenge due to the difficulty in predicting rates of bony union and [...] Read more.
Background and Objectives: Femoral neck fractures are common and constitute one of the largest healthcare burdens of the modern age. Fractures within the joint capsule (intracapsular) provide a specific surgical challenge due to the difficulty in predicting rates of bony union and whether the blood supply to the femoral head has been disrupted in a way that would lead to avascular necrosis. Most femoral neck fractures are treated surgically, aiming to maintain mobility, whilst reducing pain and complications associated with prolonged bedrest. Materials and Methods: We performed a narrative review of intracapsular hip fracture management, highlighting the latest advancements in fixation techniques, generating an evidence-based algorithm for their management. Results: Multiple different fracture configurations are encountered within the category of intracapsular hip fractures, with each pattern having different optimal surgical strategies. Additionally, these injuries typically occur in patients where further procedures due to operative complications are associated with a considerable increase in mortality, highlighting the need for choosing the correct index operation. Conclusions: Factors such as pathological causes for the fracture, pre-existing symptomatic osteoarthritis, patient’s physiological age and fracture displacement all need to be considered when choosing optimal management. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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9 pages, 24796 KiB  
Review
Treatment of Intertrochanteric Femur Fractures with Hip Arthroplasty in Older Patients: A Narrative Review of Indications and Outcomes
by Tiago Martinho and Karl Stoffel
Medicina 2021, 57(8), 763; https://doi.org/10.3390/medicina57080763 - 27 Jul 2021
Cited by 7 | Viewed by 6584
Abstract
Intertrochanteric femur fractures are common in older patients and often have a significant impact on disability. The treatment aims to achieve a rapid return to the prior functional level with a low rate of complications and mortality. Surgical management by internal fixation is [...] Read more.
Intertrochanteric femur fractures are common in older patients and often have a significant impact on disability. The treatment aims to achieve a rapid return to the prior functional level with a low rate of complications and mortality. Surgical management by internal fixation is the mainstay of treatment for most of these fractures. Even when treated with intramedullary nails, the overall complication rates are high, especially for unstable or highly comminuted fractures or in the presence of poor bone quality. Hip arthroplasty is an alternative in older patients with intertrochanteric femur fractures at high risk of fixation failure or with concomitant intraarticular pathologies. Especially patients whose condition precludes prolonged bedrest and who are at risk of significant deterioration if their locomotor function cannot be restored rapidly are likely to benefit from hip arthroplasty. The choice of the surgical technique mainly depends on the surgeon’s preferences and the fracture characteristics. Bipolar hemiarthroplasty is the most common type of prosthesis used with primary or revision femoral stems. Compared with intramedullary nails, hip arthroplasty has a better early functional outcome and lower rates of surgical complications as well as reoperations. However, the functional outcome and the mortality rate in the longer term tend to favor intramedullary nails, even though the results are inconsistent, and a statistically significant difference cannot always be obtained. Currently, there are no guidelines that define the role of hip arthroplasty in the treatment of intertrochanteric femur fractures in older patients. The literature only offers an overview of the possibilities of the usage of hip arthroplasty, but methodological limitations are common, and evidence levels are low. Further studies are needed to identify the intertrochanteric fractures that are at high risk of internal fixation failure, the characteristics that determine which patients may benefit most from hip arthroplasty, and the optimal surgical technique. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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Other

Jump to: Research, Review

13 pages, 14566 KiB  
Case Report
The Role of Free Tissue Transfers for Defect Coverage over the Body in Geriatric Populations
by Elif Kulakli-Inceleme, Matthias Knobe, Elmar Fritsche and Mario F. Scaglioni
Medicina 2021, 57(8), 795; https://doi.org/10.3390/medicina57080795 - 01 Aug 2021
Cited by 2 | Viewed by 1504
Abstract
The treatment of soft tissue defects in multimorbid frail patients requires optimized preoperative and perioperative management with a differentiated interdisciplinary approach. Preoperative assessment with established scores, such as the ASA score, is important in order to stratify the operative complication risk. Following the [...] Read more.
The treatment of soft tissue defects in multimorbid frail patients requires optimized preoperative and perioperative management with a differentiated interdisciplinary approach. Preoperative assessment with established scores, such as the ASA score, is important in order to stratify the operative complication risk. Following the reconstructive ladder is important to avoid unnecessary long operations and consecutively higher operative risks. In cases where a free flap procedure is needed, infections should be treated properly, and vascular status and coagulation should be optimized before performing a free flap procedure. Attention should be paid to maintain independency, functionality and quality of life while choosing the best treatment option. Full article
(This article belongs to the Special Issue Hip and Fragility Fracture Management)
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