Special Issue "Applications and Limitations of Dendrimers in Medicine"

Dear Colleagues,

Dendrimers are polymeric globular nanostructures characterized by branched repeating units that can possess a large number of exposed neutral, anionic, or cationic terminal groups on their surface. Great interest has been shown in the medical applications of dendrimers, especially for their capacity to be used as targeted drug/gene delivery systems, and in therapeutic imaging. Some dendrimers can also be used as a treatment/prevention agent in various diseases mostly due to their antifungal, antibacterial, antioxidant, anti-inflammatory, and cytotoxic effects. Therapeutic compounds can either be entrapped within the dendrimer core, or bound to its surface functional groups. An additional layer of targeting ligands can be applied to dendrimers to increase their biodistribution and reduce immune clearance. Advances in the application of dendrimers in last years have given scientists a potential tool to prevent or treat diseases. Despite their promising efficacy in medicine, it is necessary to more accurately predict some of the adverse effects that may arise following exposure to dendrimers. In this regard, the aim of the present special Issue is to present the applications and limitations of dendrimers from a medical point of view.

Dr. Sara Salatin
Guest Editor

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• dendrimers
• medicine
• polymeric structure
• branched units
• drug delivery
• gene delivery
• imaging agent