Recent Advances in Periodontics and Dental Implantology: Part II

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 6014

Special Issue Editor

Department of Periodontics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Interests: bone; bone biology; tissue engineering; stem cells; instrumentation; enzyme kinetics; bone regeneration; dental implants; biomaterials; oral health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With the advancement of technology, great progress has been made in the periodontology field. The prevalence of periodontal disease is relatively high and has been reported at 20­–45% or higher. Various treatments and biomaterials have been applied to increase the effectiveness of periodontal treatment. The long-term effects of periodontal treatment have been published. Despite advances in periodontal treatment, tooth extraction and further implant placement are being made. A protocol to increase the success rate of implants has been proposed. Various methods have been proposed that can be used in areas where the placement of dental implants is difficult. Stem cells and growth factors have been used as various biomaterials.

The scope of this Special Issue will serve as a forum for papers addressing the following concepts:

  • Understanding and mechanisms of periodontal disease;
  • Treatment of periodontal disease;
  • Short- and long-term effects of periodontal treatment;
  • Various soft and hard tissue regeneration methods;
  • Clinical outcome of dental implants;
  • Enhancement of efficacy with application of growth factors;
  • Cell therapy in periodontal and implant treatment.

Dr. Jun-Beom Park
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • periodontitis
  • inflammation
  • epidemiology
  • oral health
  • bone regeneration
  • bone biology
  • tissue engineering
  • dental implants
  • biomaterials
  • stem cells

Published Papers (5 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Other

10 pages, 282 KiB  
Article
Assessing the Reliability of Miller’s Classification and Cairo’s Classification in Classifying Gingival Recession Defects: A Comparison Study
by Hammam I. Fageeh, Hytham N. Fageeh, Ashok Kumar Bhati, Abdulaziz Yahay Thubab, Haitham Mohammed Hassan Sharrahi, Yahya Sulaiman Aljabri and Faisal Ibrahim Alotaibi
Medicina 2024, 60(2), 205; https://doi.org/10.3390/medicina60020205 - 25 Jan 2024
Viewed by 1304
Abstract
Background and Objectives: Gingival recession results in adverse aesthetics and root sensitivity, and there is a need to treat and prevent its further progression. To overcome these problems, various advances have been made by clinicians in treating gingival recession based on the type [...] Read more.
Background and Objectives: Gingival recession results in adverse aesthetics and root sensitivity, and there is a need to treat and prevent its further progression. To overcome these problems, various advances have been made by clinicians in treating gingival recession based on the type of gingival recession. Miller’s classification has been used for a long time to classify the type of recession. However, certain limitations have been found with use of Miller’s classification such as a lack of clarity in the method for measuring soft and hard tissue loss in the interproximal area. Cairo classification was proposed to overcome limitations of Miller’s classification to classify gingival recession. Cairo’s classification is a treatment-oriented classification based on buccal and interproximal attachment loss. Therefore, the study was conducted to assess and compare the reliability of Miller’s and Cairo’s classifications in determining gingival recession. Material and methods: A total of 220 buccal gingival recession defects were included in the study based on the inclusion and exclusion criteria. Four examiners were included in the study. Two examiners classified the recession defects according to Miller’s classification and the other two examiners classified recession defects according to Cairo’s classification at baseline and at a 1-week interval. Statistical analysis was conducted using SPSS software version 25.0 using Cohen’s kappa correlation coefficient and Chi-square test statistics to determine the intra- and inter-rater agreement among the examiners for the two gingival recession classification systems. A p value of <0.05 was considered statistically significant. Results: The intra-rater agreement for Cairo’s classification was 0.86 and 0.82, whereas for Miller’s classification, it was found to be 0.68. The inter-rater reliability agreement for Cairo’s classification was 0.82 and 0.8, whereas for the Miller’s classification, it was 0.56 and 0.67. Conclusions: Within the limitations of the study, it was found that Cairo’s classification is clearer and more reliable than Miller’s classification in the assessment of gingival recession. Full article
(This article belongs to the Special Issue Recent Advances in Periodontics and Dental Implantology: Part II)
12 pages, 1609 KiB  
Article
Bone Morphogenetic Protein-9 Promotes Osteogenic Differentiation and Mineralization in Human Stem-Cell-Derived Spheroids
by Sung-Bin Lee, Hyun-Jin Lee and Jun-Beom Park
Medicina 2023, 59(7), 1315; https://doi.org/10.3390/medicina59071315 - 16 Jul 2023
Viewed by 904
Abstract
Background and Objectives: Alkaline phosphatase activity, mineralized matrix, and osteogenic-related gene expression have been shown to increase in response to bone morphogenetic protein-9 (BMP-9). In this study, spheroids derived from human gingival stem cells were used to determine the effects of BMP-9 on [...] Read more.
Background and Objectives: Alkaline phosphatase activity, mineralized matrix, and osteogenic-related gene expression have been shown to increase in response to bone morphogenetic protein-9 (BMP-9). In this study, spheroids derived from human gingival stem cells were used to determine the effects of BMP-9 on cell survival, osteogenesis, and mineralization. Materials and Methods: Human gingival stem cells were used to produce spheroids and then grown to concentrations of 0, 0.1, 1, 10, and 100 ng/mL with BMP-9. On days 1, 3, 5, and 7, morphological examination was carried out. A live/dead assay and Cell Counting Kit-8 was used to assess the vitality of cells. On days 7 and 14, alkaline phosphatase activity assays were carried out using a commercially available kit to examine the osteogenic differentiation of cell spheroids. Alizarin Red Staining was performed on the 7th and 14th days to evaluate mineralization, and RUNX2 and COL1A1 expression levels were evaluated on the 7th and 14th days using real-time polymerase chain reactions. Results: The BMP-9 added at the measured quantities did not appear to alter the shape of the well-formed spheroids produced by stem cells on day 1. In addition, treatment with BMP-9 at doses of 0, 0.1, 1, 10, or 100 ng/mL did not significantly alter cell diameter. Throughout the whole experimental process, viability was maintained. On day 14, the alkaline phosphatase activity in the groups dosed with 0.1, 1, 10, or 100 ng/mL was statistically higher than that in the unloaded control group (p < 0.05). According to qPCR data, the mRNA expression level of RUNX2 with 1 ng/mL dosing was higher on day 7 compared to that of the unloaded control group (p < 0.05). Conclusions: These findings suggest that BMP-9 can be employed to stimulate early osteogenic differentiation in stem cell spheroids. Full article
(This article belongs to the Special Issue Recent Advances in Periodontics and Dental Implantology: Part II)
Show Figures

Figure 1

Other

Jump to: Research

15 pages, 4076 KiB  
Case Report
A Novel Approach for the Treatment of Recurrent Oroantral Fistula Occurring at an Infected Sinus Augmentation Site
by Won-Bae Park, Min-Soo Bae, Wonhee Park, Hyun-Chang Lim and Ji-Young Han
Medicina 2024, 60(2), 343; https://doi.org/10.3390/medicina60020343 - 19 Feb 2024
Viewed by 666
Abstract
Closing a recurrent oroantral fistula (OAF) that occurs at an infected sinus augmentation site is a challenge for clinicians. The recurrent OAF has a detrimental impact on bone regeneration and subsequent implant placement. This case report includes three cases in which sinus graft [...] Read more.
Closing a recurrent oroantral fistula (OAF) that occurs at an infected sinus augmentation site is a challenge for clinicians. The recurrent OAF has a detrimental impact on bone regeneration and subsequent implant placement. This case report includes three cases in which sinus graft infection and OAF occurred after maxillary sinus augmentation (MSA). In these cases, treatments to control sinus infection were performed using an otolaryngologist; then, intraoral interventions comprising mucosal flap procedures, bone grafts, and barrier membrane applications were performed 2–5 times by oral surgeons. Nevertheless, OAF recurred persistently. The failure to stop OAF recurrence may be due to the inability to effectively block air pressure at the OAF site. Following a comprehensive debridement of the infected tissue at the previous sinus augmentation site, a pouch was created through sinus mucosal elevation. The perforated sinus mucosa at the OAF site was covered with a non-resorbable membrane in one case and with resorbable collagen membranes in the other two cases, followed by bone grafting within the pouch. Lastly, this procedure was completed by blocking the entrance of the pouch with a cortical bone shell graft and a resorbable collagen membrane. The cortical bone shell graft, obstructing the air pressure from the nasal cavity, facilitated bone formation, and, ultimately, allowed for implant placement. Within the limitations of the present case report, the application of a guided bone regeneration technique involving a cortical bone shell graft and a barrier membrane enabled the closure of the recurrent OAF and subsequent implant placement. Full article
(This article belongs to the Special Issue Recent Advances in Periodontics and Dental Implantology: Part II)
Show Figures

Figure 1

10 pages, 5601 KiB  
Case Report
Oral Lichenoid Lesion following Dental Implant Placement and Successful Management with Free Gingival Graft: A Case Report with 10-Year Follow-Up
by Won-Bae Park, Junghun Moon, Seungil Shin and Ji-Youn Hong
Medicina 2023, 59(12), 2188; https://doi.org/10.3390/medicina59122188 - 17 Dec 2023
Viewed by 810
Abstract
Titanium and metal alloys are widely used in implants, crowns, and bridges in implant dentistry owing to their biocompatibility. In this case report of a 45-year-old female patient, multiple implants were placed in five different sextants at different time points. Notably, oral lichenoid [...] Read more.
Titanium and metal alloys are widely used in implants, crowns, and bridges in implant dentistry owing to their biocompatibility. In this case report of a 45-year-old female patient, multiple implants were placed in five different sextants at different time points. Notably, oral lichenoid lesions (OLL) occurred in three sextants following implant placement, strongly suggesting that the dental implants or prostheses were the causative factors for OLL. The lesion was of the reticular type with erythematous surroundings and was symptomatic. Although several conservative treatments, including repeated topical application of corticosteroids, were repeatedly continued, no discernible improvement or alleviation of symptoms was observed. Consequently, surgical excision and replacement of the lesion with a free gingival graft (FGG) harvested from the palatal soft tissue were performed. No clinical symptoms or recurrence of lesions were observed during 10 years of follow-up post-FGG. Full article
(This article belongs to the Special Issue Recent Advances in Periodontics and Dental Implantology: Part II)
Show Figures

Figure 1

9 pages, 557 KiB  
Systematic Review
Relationship between Deep Marginal Elevation and Periodontal Parameters: A Systematic Review
by Mohammed Fareed Felemban, Osama Khattak, Thani Alsharari, Abdulrahman H. Alzahrani, Kiran Kumar Ganji and Azhar Iqbal
Medicina 2023, 59(11), 1948; https://doi.org/10.3390/medicina59111948 - 03 Nov 2023
Viewed by 1888
Abstract
Background and Objectives: This review focuses on reviewing studies from the literature regarding the effects of deep margin elevation on the surrounding periodontium. Materials and Methods: A review of the literature was carried out using the following online databases: Embase, The [...] Read more.
Background and Objectives: This review focuses on reviewing studies from the literature regarding the effects of deep margin elevation on the surrounding periodontium. Materials and Methods: A review of the literature was carried out using the following online databases: Embase, The Cochrane Library, MEDLINE-PubMed and Google Scholar. Our search was limited to articles from 2010 to 2023. The search terms consisted of keywords and MeSH terms, which were ‘deep margin elevation’, ‘coronal margin relocation’, ‘periodontium’ and ‘periodontal tissues’. The literature was searched thoroughly by two reviewers. Initially, the titles of the articles were extracted. After removing irrelevant and duplicate articles, abstracts were assessed for relevant articles. Finally, the reviewers analyzed full-text articles. Results: A total of twelve articles, including one randomized clinical trial, three systematic reviews, two prospective cohort, three case series, one a clinical study, one pilot study and one a retrospective study, were selected and analyzed. Conclusions: The review suggests potential benefits of Deep Margin Elevation (DME) over surgical crown lengthening due to reduced invasiveness, yet conclusive effects on periodontal tissue remain unclear, warranting further studies on clinical parameters and inflammatory biomarkers. Full article
(This article belongs to the Special Issue Recent Advances in Periodontics and Dental Implantology: Part II)
Show Figures

Figure 1

Back to TopTop