materials-logo

Journal Browser

Journal Browser

Bioactive Glasses 2017

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (31 January 2018) | Viewed by 67588

Special Issue Editors

Institute of Materials Physics and Engineering, Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy
Interests: ceramics; glasses; porous materials; additive manufacturing; bioactive glasses; bioceramics; composites; tissue engineering; multifunctional biomaterials; biomedical scaffolds; advanced ceramics; sustainable materials; waste management
Special Issues, Collections and Topics in MDPI journals
Department of Applied Science and Technology (DISAT), Politecnico di Torino, Turin, Italy
Interests: biomaterials; bioactive glasses; antibacterial materials; surface functionalization; magnetic materials; nanomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For centuries, glass has played an important role in the practical and aesthetic aspects of our lives and culture. Some special types of glass have revolutionized medicine since Larry Hench invented 45S5 Bioglass®, almost 50 years ago, at the University of Florida. This material was the first able to bond to bone, forming a tight interface, and launched our modern idea of biomaterials science. Many other bioactive glass compositions have been developed over the years, which have controllable degradation rates, so that glass implant dissolution can be closely matched to the rate of new bone formation. Bioactive glasses can be doped with trace quantities of metal elements that, once released, are known to be beneficial for healthy bone growth (e.g., Sr) or to elicit a therapeutic effect, such as antibacterial properties (e.g., Ag).

Recent advances in biomaterials processing have led to the creation of functional coatings, 3D porous scaffolds, fibrous constructs, and moldable implants with a range of mechanical properties suitable for the repair of both load-bearing and non-loaded bone. Furthermore, emerging applications of bioactive glasses in contact with soft tissues are increasingly attracting the interest of researchers. Recent work has shown the ability of bioactive glasses to promote angiogenesis, which is a critical requirement for promoting both bone and soft tissue regeneration, such as wound healing. Surface functionalization and incorporation in composite biomaterials are valuable strategies to develop bioactive glass-based systems for the local delivery of drugs and therapeutic biomolecules, which are key for the treatment of a number of diseases ranging from chronic infections to malignant tumors.

In summary, new and continuous advances in bioactive glass processing technologies and novel applications of biomedical glasses in tissue engineering and advanced therapy bring further honor to the long history of glass in medicine and open unexpected scenarios for patient’s treatment and rehabilitation.

It is, therefore, our immense pleasure to invite you to submit a manuscript for the Special Issue, “Bioactive Glasses 2017”. Full research articles, short communications and comprehensive review papers covering all aspects of design, processing, characterization, modelling and applications of bioactive glasses are welcome.

Francesco Baino
Aldo R. Boccaccini
Enrica Verné
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioactive glasses

  • Silicate glasses

  • Borate glasses

  • Phosphate glasses

  • Composites

  • Hybrids

  • Bioactivity

  • Scaffolds

  • Coatings

  • Additive manufacturing

  • Surface functionalization

  • Modelling

  • Tissue engineering

  • Drug delivery

  • Ion release

Published Papers (12 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

13 pages, 9363 KiB  
Article
Electrospun F18 Bioactive Glass/PCL—Poly (ε-caprolactone)—Membrane for Guided Tissue Regeneration
by Lucas Hidalgo Pitaluga, Marina Trevelin Souza, Edgar Dutra Zanotto, Martin Eduardo Santocildes Romero and Paul V. Hatton
Materials 2018, 11(3), 400; https://doi.org/10.3390/ma11030400 - 08 Mar 2018
Cited by 35 | Viewed by 4711
Abstract
Barrier membranes that are used for guided tissue regeneration (GTR) therapy usually lack bioactivity and the capability to promote new bone tissue formation. However, the incorporation of an osteogenic agent into polymeric membranes seems to be the most assertive strategy to enhance their [...] Read more.
Barrier membranes that are used for guided tissue regeneration (GTR) therapy usually lack bioactivity and the capability to promote new bone tissue formation. However, the incorporation of an osteogenic agent into polymeric membranes seems to be the most assertive strategy to enhance their regenerative potential. Here, the manufacturing of composite electrospun membranes made of poly (ε-caprolactone) (PCL) and particles of a novel bioactive glass composition (F18) is described. The membranes were mechanically and biologically tested with tensile strength tests and tissue culture with MG-63 osteoblast-like cell line, respectively. The PCL-F18 composite membranes demonstrated no increased cytotoxicity and an enhanced osteogenic potential when compared to pure PCL membranes. Moreover, the addition of the bioactive phase increased the membrane tensile strength. These preliminary results suggested that these new membranes can be a strong candidate for small bone injuries treatment by GTR technique. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

13 pages, 4768 KiB  
Article
Bioactive Glass-Ceramic Foam Scaffolds from ‘Inorganic Gel Casting’ and Sinter-Crystallization
by Hamada Elsayed, Acacio Rincón Romero, Giulia Molino, Chiara Vitale Brovarone and Enrico Bernardo
Materials 2018, 11(3), 349; https://doi.org/10.3390/ma11030349 - 27 Feb 2018
Cited by 21 | Viewed by 5291
Abstract
Highly porous bioactive glass-ceramic scaffolds were effectively fabricated by an inorganic gel casting technique, based on alkali activation and gelification, followed by viscous flow sintering. Glass powders, already known to yield a bioactive sintered glass-ceramic (CEL2) were dispersed in an alkaline solution, with [...] Read more.
Highly porous bioactive glass-ceramic scaffolds were effectively fabricated by an inorganic gel casting technique, based on alkali activation and gelification, followed by viscous flow sintering. Glass powders, already known to yield a bioactive sintered glass-ceramic (CEL2) were dispersed in an alkaline solution, with partial dissolution of glass powders. The obtained glass suspensions underwent progressive hardening, by curing at low temperature (40 °C), owing to the formation of a C–S–H (calcium silicate hydrate) gel. As successful direct foaming was achieved by vigorous mechanical stirring of gelified suspensions, comprising also a surfactant. The developed cellular structures were later heat-treated at 900–1000 °C, to form CEL2 glass-ceramic foams, featuring an abundant total porosity (from 60% to 80%) and well-interconnected macro- and micro-sized cells. The developed foams possessed a compressive strength from 2.5 to 5 MPa, which is in the range of human trabecular bone strength. Therefore, CEL2 glass-ceramics can be proposed for bone substitutions. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

15 pages, 3407 KiB  
Article
Fe-Doped Sol-Gel Glasses and Glass-Ceramics for Magnetic Hyperthermia
by Francesco Baino, Elisa Fiume, Marta Miola, Federica Leone, Barbara Onida, Francesco Laviano, Roberto Gerbaldo and Enrica Verné
Materials 2018, 11(1), 173; https://doi.org/10.3390/ma11010173 - 22 Jan 2018
Cited by 46 | Viewed by 6822
Abstract
This work deals with the synthesis and characterization of novel Fe-containing sol-gel materials obtained by modifying the composition of a binary SiO2-CaO parent glass with the addition of Fe2O3. The effect of different processing conditions (calcination in [...] Read more.
This work deals with the synthesis and characterization of novel Fe-containing sol-gel materials obtained by modifying the composition of a binary SiO2-CaO parent glass with the addition of Fe2O3. The effect of different processing conditions (calcination in air vs. argon flowing) on the formation of magnetic crystalline phases was investigated. The produced materials were analyzed from thermal (hot-stage microscopy, differential thermal analysis, and differential thermal calorimetry) and microstructural (X-ray diffraction) viewpoints to assess both the behavior upon heating and the development of crystalline phases. N2 adsorption–desorption measurements allowed determining that these materials have high surface area (40–120 m2/g) and mesoporous texture with mesopore size in the range of 18 to 30 nm. It was assessed that the magnetic properties can actually be tailored by controlling the Fe content and the environmental conditions (oxidant vs. inert atmosphere) during calcination. The glasses and glass-ceramics developed in this work show promise for applications in bone tissue healing which require the use of biocompatible magnetic implants able to elicit therapeutic actions, such as hyperthermia for bone cancer treatment. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

10 pages, 2870 KiB  
Article
Laser Machining and In Vitro Assessment of Wollastonite-Tricalcium Phosphate Eutectic Glasses and Glass-Ceramics
by Daniel Sola and Lorena Grima
Materials 2018, 11(1), 125; https://doi.org/10.3390/ma11010125 - 13 Jan 2018
Cited by 5 | Viewed by 3947
Abstract
Bioactivity and ingrowth of ceramic implants is commonly enhanced by a suitable interconnected porous network. In this work, the laser machining of CaSiO3‒Ca3(PO4)2 biocompatible eutectic glass-ceramics and glasses was studied. For this purpose, 300 µm diameter [...] Read more.
Bioactivity and ingrowth of ceramic implants is commonly enhanced by a suitable interconnected porous network. In this work, the laser machining of CaSiO3‒Ca3(PO4)2 biocompatible eutectic glass-ceramics and glasses was studied. For this purpose, 300 µm diameter craters were machined by using pulsed laser radiation at 532 nm with a pulsewidth in the nanosecond range. Machined samples were soaked in simulated body fluid for 2 months to assess the formation of a hydroxyapatite layer on the surface of the laser machined areas. The samples were manufactured by the laser floating zone technique using a CO2 laser. Morphology, composition and microstructure of the machined samples were described by Field Emission Scanning Electron Microscopy, Energy Dispersive X-ray Spectroscopy and micro-Raman Spectroscopy. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

2285 KiB  
Article
Laser-Induced Breakdown Spectroscopy (LIBS) for Monitoring the Formation of Hydroxyapatite Porous Layers
by Daniel Sola, Daniel Paulés, Lorena Grima and Jesús Anzano
Materials 2017, 10(12), 1395; https://doi.org/10.3390/ma10121395 - 06 Dec 2017
Cited by 9 | Viewed by 4775
Abstract
Laser-induced breakdown spectroscopy (LIBS) is applied to characterize the formation of porous hydroxyapatite layers on the surface of 0.8CaSiO3-0.2Ca3(PO4)2 biocompatible eutectic glass immersed in simulated body fluid (SBF). Compositional and structural characterization analyses were also conducted [...] Read more.
Laser-induced breakdown spectroscopy (LIBS) is applied to characterize the formation of porous hydroxyapatite layers on the surface of 0.8CaSiO3-0.2Ca3(PO4)2 biocompatible eutectic glass immersed in simulated body fluid (SBF). Compositional and structural characterization analyses were also conducted by field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX), and micro-Raman spectroscopy. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

1570 KiB  
Article
Micro-Computed-Tomography-Guided Analysis of In Vitro Structural Modifications in Two Types of 45S5 Bioactive Glass Based Scaffolds
by Fabian Westhauser, Francesca Ciraldo, Preethi Balasubramanian, Anne-Sophie Senger, Gerhard Schmidmaier, Arash Moghaddam and Aldo R. Boccaccini
Materials 2017, 10(12), 1341; https://doi.org/10.3390/ma10121341 - 23 Nov 2017
Cited by 12 | Viewed by 4605
Abstract
Three-dimensional 45S5 bioactive glass (BG)-based scaffolds are being investigated for bone regeneration. Besides structural properties, controlled time-dependent alteration of scaffold morphology is crucial to achieve optimal scaffold characteristics for successful bone repair. There is no in vitro evidence concerning the dependence between structural [...] Read more.
Three-dimensional 45S5 bioactive glass (BG)-based scaffolds are being investigated for bone regeneration. Besides structural properties, controlled time-dependent alteration of scaffold morphology is crucial to achieve optimal scaffold characteristics for successful bone repair. There is no in vitro evidence concerning the dependence between structural characteristics and dissolution behavior of 45S5 BG-based scaffolds of different morphology. In this study, the dissolution behavior of scaffolds fabricated by the foam replica method using polyurethane foam (Group A) and maritime sponge Spongia Agaricina (Group B) as sacrificial templates was analyzed by micro-computed-tomography (µCT). The scaffolds were immersed in Dulbecco’s Modified Eagle Medium for 56 days under static cell culture conditions and underwent µCT-analysis initially, and after 7, 14, and 56 days. Group A showed high porosity (91%) and trabecular structure formed by macro-pores (average diameter 692 µm ± 72 µm). Group-B-scaffolds were less porous (51%), revealing an optimal pore size distribution within the window of 110–500 µm pore size diameter, combined with superior mechanical stability. Both groups showed similar structural alteration upon immersion. Surface area and scaffold volume increased whilst density decreased, reflecting initial dissolution followed by hydroxycarbonate-apatite-layer-formation on the scaffold surfaces. In vitro- and/or in vivo-testing of cell-seeded BG-scaffolds used in this study should be performed to evaluate the BG-scaffolds’ time-dependent osteogenic properties in relation to the measured in vitro structural changes. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

1972 KiB  
Article
Effect of Alumina Incorporation on the Surface Mineralization and Degradation of a Bioactive Glass (CaO-MgO-SiO2-Na2O-P2O5-CaF2)-Glycerol Paste
by Dilshat Tulyaganov, Khasan Abdukayumov, Olim Ruzimuradov, Mirabbos Hojamberdiev, Emanuel Ionescu and Ralf Riedel
Materials 2017, 10(11), 1324; https://doi.org/10.3390/ma10111324 - 18 Nov 2017
Cited by 12 | Viewed by 5816
Abstract
This study investigates the dissolution behavior as well as the surface biomineralization in simulated body fluid (SBF) of a paste composed of glycerol (gly) and a bioactive glass in the system CaO-MgO-SiO2-Na2O-P2O5-CaF2 (BG). The [...] Read more.
This study investigates the dissolution behavior as well as the surface biomineralization in simulated body fluid (SBF) of a paste composed of glycerol (gly) and a bioactive glass in the system CaO-MgO-SiO2-Na2O-P2O5-CaF2 (BG). The synthesis of the bioactive glass in an alumina crucible has been shown to significantly affect its bioactivity due to the incorporation of aluminum (ca. 1.3–1.4 wt %) into the glass network. Thus, the kinetics of the hydroxyapatite (HA) mineralization on the glass prepared in the alumina crucible was found to be slower than that reported for the same glass composition prepared in a Pt crucible. It is considered that the synthesis conditions lead to the incorporation of small amount of aluminum into the BG network and thus delay the HA mineralization. Interestingly, the BG-gly paste was shown to have significantly higher bioactivity than that of the as-prepared BG. Structural analysis of the paste indicate that glycerol chemically interacts with the glass surface and strongly alter the glass network architecture, thus generating a more depolymerized network, as well as an increased amount of silanol groups at the surface of the glass. In particular, BG-gly paste features early intermediate calcite precipitation during immersion in SBF, followed by hydroxyapatite formation after ca. seven days of SBF exposure; whereas the HA mineralization seems to be suppressed in BG, probably a consequence of the incorporation of aluminum into the glass network. The results obtained within the present study reveal the positive effect of using pastes based on bioactive glasses and organic carriers (here alcohols) which may be of interest not only due to their advantageous visco-elastic properties, but also due to the possibility of enhancing the glass bioactivity upon surface interactions with the organic carrier. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

3101 KiB  
Article
In Vitro Degradation of Borosilicate Bioactive Glass and Poly(l-lactide-co-ε-caprolactone) Composite Scaffolds
by Jenna Tainio, Kaarlo Paakinaho, Niina Ahola, Markus Hannula, Jari Hyttinen, Minna Kellomäki and Jonathan Massera
Materials 2017, 10(11), 1274; https://doi.org/10.3390/ma10111274 - 06 Nov 2017
Cited by 20 | Viewed by 4811
Abstract
Composite scaffolds were obtained by mixing various amounts (10, 30 and 50 weight % [wt %]) of borosilicate bioactive glass and poly(l-lactide-co-ε-caprolactone) (PLCL) copolymer. The composites were foamed using supercritical CO2. An increase in the glass content led to [...] Read more.
Composite scaffolds were obtained by mixing various amounts (10, 30 and 50 weight % [wt %]) of borosilicate bioactive glass and poly(l-lactide-co-ε-caprolactone) (PLCL) copolymer. The composites were foamed using supercritical CO2. An increase in the glass content led to a decrease in the pore size and density. In vitro dissolution/reaction test was performed in simulated body fluid. As a function of immersion time, the solution pH increased due to the glass dissolution. This was further supported by the increasing amount of Ca in the immersing solution with increasing immersion time and glass content. Furthermore, the change in scaffold mass was significantly greater with increasing the glass content in the scaffold. However, only the scaffolds containing 30 and 50 wt % of glasses exhibited significant hydroxyapatite (HA) formation at 72 h of immersion. The compression strength of the samples was also measured. The Young’s modulus was similar for the 10 and 30 wt % glass-containing scaffolds whereas it increased to 90 MPa for the 50 wt % glass containing scaffold. Upon immersion up to 72 h, the Young’s modulus increased and then remained constant for longer immersion times. The scaffold prepared could have great potential for bone and cartilage regeneration. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

12116 KiB  
Article
Mesoporous Bioactive Glass Functionalized 3D Ti-6Al-4V Scaffolds with Improved Surface Bioactivity
by Xiaotong Ye, Sander Leeflang, Chengtie Wu, Jiang Chang, Jie Zhou and Zhiguang Huan
Materials 2017, 10(11), 1244; https://doi.org/10.3390/ma10111244 - 27 Oct 2017
Cited by 28 | Viewed by 5665
Abstract
Porous Ti-6Al-4V scaffolds fabricated by means of selective laser melting (SLM), having controllable geometrical features and preferable mechanical properties, have been developed as a class of biomaterials that hold promising potential for bone repair. However, the inherent bio-inertness of the Ti-6Al-4V alloy as [...] Read more.
Porous Ti-6Al-4V scaffolds fabricated by means of selective laser melting (SLM), having controllable geometrical features and preferable mechanical properties, have been developed as a class of biomaterials that hold promising potential for bone repair. However, the inherent bio-inertness of the Ti-6Al-4V alloy as the matrix of the scaffolds results in a lack in the ability to stimulate bone ingrowth and regeneration. The aim of the present study was to develop a bioactive coating on the struts of SLM Ti-6Al-4V scaffolds in order to add the desired surface osteogenesis ability. Mesoporous bioactive glasses (MBGs) coating was applied on the strut surfaces of the SLM Ti-6Al-4V scaffolds through spin coating, followed by a heat treatment. It was found that the coating could maintain the characteristic mesoporous structure and chemical composition of MBG, and establish good interfacial adhesion to the Ti-6Al-4V substrate. The compressive strength and pore interconnectivity of the scaffolds were not affected by the coating. Moreover, the results obtained from in vitro cell culture experiments demonstrated that the attachment, proliferation, and differentiation of human bone marrow stromal cells (hBMSCs) on the MBG-coated Ti-6Al-4V scaffolds were improved as compared with those on the conventional bioactive glass (BG)-coated Ti-6Al-4V scaffolds and bare-metal Ti-6Al-4V scaffolds. Our results demonstrated that the MBG coating by using the spinning coating method could be an effective approach to achieving enhanced surface biofunctionalization for SLM Ti-6Al-4V scaffolds. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

2136 KiB  
Article
In Vitro Human Umbilical Vein Endothelial Cells Response to Ionic Dissolution Products from Lithium-Containing 45S5 Bioactive Glass
by Luis A. Haro Durand, Gabriela E. Vargas, Rosa Vera-Mesones, Alberto Baldi, María P. Zago, María A. Fanovich, Aldo R. Boccaccini and Alejandro Gorustovich
Materials 2017, 10(7), 740; https://doi.org/10.3390/ma10070740 - 03 Jul 2017
Cited by 31 | Viewed by 5118
Abstract
Since lithium (Li+) plays roles in angiogenesis, the localized and controlled release of Li+ ions from bioactive glasses (BGs) represents a promising alternative therapy for the regeneration and repair of tissues with a high degree of vascularization. Here, microparticles from [...] Read more.
Since lithium (Li+) plays roles in angiogenesis, the localized and controlled release of Li+ ions from bioactive glasses (BGs) represents a promising alternative therapy for the regeneration and repair of tissues with a high degree of vascularization. Here, microparticles from a base 45S5 BG composition containing (wt %) 45% SiO2, 24.5% Na2O, 24.5% CaO, and 6% P2O5, in which Na2O was partially substituted by 5% Li2O (45S5.5Li), were obtained. The results demonstrate that human umbilical vein endothelial cells (HUVECs) have greater migratory and proliferative response and ability to form tubules in vitro after stimulation with the ionic dissolution products (IDPs) of the 45S5.5Li BG. The results also show the activation of the canonical Wnt/β-catenin pathway and the increase in expression of proangiogenic cytokines insulin like growth factor 1 (IGF1) and transforming growth factor beta (TGFβ). We conclude that the IDPs of 45S5.5Li BG would act as useful inorganic agents to improve tissue repair and regeneration, ultimately stimulating HUVECs behavior in the absence of exogenous growth factors. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

Review

Jump to: Research

11 pages, 560 KiB  
Review
Recent Evidence on Bioactive Glass Antimicrobial and Antibiofilm Activity: A Mini-Review
by Lorenzo Drago, Marco Toscano and Marta Bottagisio
Materials 2018, 11(2), 326; https://doi.org/10.3390/ma11020326 - 24 Feb 2018
Cited by 141 | Viewed by 7578
Abstract
Bone defects caused by trauma or pathological events are major clinical and socioeconomic burdens. Thus, the efforts of regenerative medicine have been focused on the development of non-biodegradable materials resembling bone features. Consequently, the use of bioactive glass as a promising alternative to [...] Read more.
Bone defects caused by trauma or pathological events are major clinical and socioeconomic burdens. Thus, the efforts of regenerative medicine have been focused on the development of non-biodegradable materials resembling bone features. Consequently, the use of bioactive glass as a promising alternative to inert graft materials has been proposed. Bioactive glass is a synthetic silica-based material with excellent mechanical properties able to bond to the host bone tissue. Indeed, when immersed in physiological fluids, bioactive glass reacts, developing an apatite layer on the granule’s surface, playing a key role in the osteogenesis process. Moreover, the contact of bioactive glass with biological fluids results in the increase of osmotic pressure and pH due to the leaching of ions from granules’ surface, thus making the surrounding environment hostile to microbial growth. The bioactive glass antimicrobial activity is effective against a wide selection of aerobic and anaerobic bacteria, either in planktonic or sessile forms. Furthermore, bioglass is able to reduce pathogens’ biofilm production. For the aforementioned reasons, the use of bioactive glass might be a promising solution for the reconstruction of bone defects, as well as for the treatment and eradication of bone infections, characterized by bone necrosis and destruction of the bone structure. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

11331 KiB  
Review
Potential of Bioactive Glasses for Cardiac and Pulmonary Tissue Engineering
by Saeid Kargozar, Sepideh Hamzehlou and Francesco Baino
Materials 2017, 10(12), 1429; https://doi.org/10.3390/ma10121429 - 15 Dec 2017
Cited by 66 | Viewed by 7306
Abstract
Repair and regeneration of disorders affecting cardiac and pulmonary tissues through tissue-engineering-based approaches is currently of particular interest. On this matter, different families of bioactive glasses (BGs) have recently been given much consideration with respect to treating refractory diseases of these tissues, such [...] Read more.
Repair and regeneration of disorders affecting cardiac and pulmonary tissues through tissue-engineering-based approaches is currently of particular interest. On this matter, different families of bioactive glasses (BGs) have recently been given much consideration with respect to treating refractory diseases of these tissues, such as myocardial infarction. The inherent properties of BGs, including their ability to bond to hard and soft tissues, to stimulate angiogenesis, and to elicit antimicrobial effects, along with their excellent biocompatibility, support these newly proposed strategies. Moreover, BGs can also act as a bioactive reinforcing phase to finely tune the mechanical properties of polymer-based constructs used to repair the damaged cardiac and pulmonary tissues. In the present study, we evaluated the potential of different forms of BGs, alone or in combination with other materials (e.g., polymers), in regards to repair and regenerate injured tissues of cardiac and pulmonary systems. Full article
(This article belongs to the Special Issue Bioactive Glasses 2017)
Show Figures

Figure 1

Back to TopTop