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Biofunctional Nanomaterials for Optical Diagnostic and Therapeutic Applications
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Biofunctional Nanomaterials for Optical Diagnostic and Therapeutic Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials and Nanotechnology".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3051

Special Issue Editor

Dr. Irina V. Balalaeva

E-Mail Website1 Website2
Guest Editor
Institute of Biology and Biomedicine, Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., Nizhny Novgorod 603022, Russia
Interests: cancer cell biology; photodynamic therapy; targeted therapy; nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development of new methods and approaches for the diagnosis and treatment of various diseases is one of the most actively developing fields of biomedicine. The creation of nanomaterials with unique optical properties ensures the emergence of biomedical technologies of a qualitatively new level. The wide variety of highly promising materials includes, but is not limited to, plasmonic metal nanomaterials, semiconductor and carbon quantum dots, nanodiamonds, photoluminescent silica nanostructures, up-converting nanoparticles, and metal–organic frameworks. Still, many issues have to be solved before these types of nanomaterials can take their deserved place among practical tools available for clinicians.

This Special Issue will collect original research and comprehensive reviews on the most recent advances in the field of biofunctional nanomaterials concerning nanomaterials with promising optical properties for biomedical application. We welcome high-quality papers covering novel nanomaterials with unique optical properties, methods for their biofuctionalization, bioimaging techniques, light-driven nanomaterials-based therapeutic approaches, theranostics applications, and nanotoxicological aspects.

Dr. Irina V. Balalaeva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Plasmon nanomaterials
  • Photoluminescent particles
  • Quantum dots
  • Carbon dots
  • Upconversion nanoparticles
  • Metal–organic frameworks
  • Biofuctionalization of nanomaterials
  • Biomedical application
  • Nanobiophotonics
  • Bioimaging
  • Optical theranostics Biomedical application
  • Nanobiophotonics
  • Bioimaging
  • Optical theranostics

Published Papers (1 paper)

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Research

16 pages, 3863 KiB  
Article
Controlled Formation of a Protein Corona Composed of Denatured BSA on Upconversion Nanoparticles Improves Their Colloidal Stability
by Samah Shanwar, Liuen Liang, Andrey V. Nechaev, Daria K. Bausheva, Irina V. Balalaeva, Vladimir A. Vodeneev, Indrajit Roy, Andrei V. Zvyagin and Evgenii L. Guryev
Materials 2021, 14(7), 1657; https://doi.org/10.3390/ma14071657 - 28 Mar 2021
Cited by 14 | Viewed by 2582
Abstract
In the natural fluidic environment of a biological system, nanoparticles swiftly adsorb plasma proteins on their surface forming a “protein corona”, which profoundly and often adversely affects their residence in the systemic circulation in vivo and their interaction with cells in vitro. It [...] Read more.
In the natural fluidic environment of a biological system, nanoparticles swiftly adsorb plasma proteins on their surface forming a “protein corona”, which profoundly and often adversely affects their residence in the systemic circulation in vivo and their interaction with cells in vitro. It has been recognized that preformation of a protein corona under controlled conditions ameliorates the protein corona effects, including colloidal stability in serum solutions. We report on the investigation of the stabilizing effects of a denatured bovine serum albumin (dBSA) protein corona formed on the surface of upconversion nanoparticles (UCNPs). UCNPs were chosen as a nanoparticle model due to their unique photoluminescent properties suitable for background-free biological imaging and sensing. UCNP surface was modified with nitrosonium tetrafluoroborate (NOBF4) to render it hydrophilic. UCNP-NOBF4 nanoparticles were incubated in dBSA solution to form a dBSA corona followed up by lyophilization. As produced dBSA-UCNP-NOBF4 demonstrated high photoluminescence brightness, sustained colloidal stability after long-term storage and the reduced level of serum protein surface adsorption. These results show promise of dBSA-based nanoparticle pretreatment to improve the amiability to biological environments towards theranostic applications. Full article
(This article belongs to the Special Issue Biofunctional Nanomaterials for Optical Diagnostic and Therapeutic Applications)
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