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Advanced Materials in Additive Manufacturing for Medical Applications
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Advanced Materials in Additive Manufacturing for Medical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Manufacturing Processes and Systems".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 12576

Special Issue Editors

Prof. Dr. Rafael Antonio Balart Gimeno

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Guest Editor
Technological Institute of Materials (ITM), Universitat Politècnica de València (UPV), 03801 Alcoy, Spain
Interests: aliphatic polyesters; blends; compatibilization; advanced characterization; functional additives; unsaturated polyester resins; composites
Special Issues, Collections and Topics in MDPI journals
Dr. Teodomiro Boronat Vitoria

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Guest Editor
Department of Mechanical and Materials Engineering, Materials Technology Institute (ITM), Universitat Politècnica de València (UPV), Valencia, Spain
Interests: polymer manufacturing; 3D printing; polyesters; medical applications; process modeling; computer-aided engineering (CAE); computer-aided manufacturing (CAM); polymer stents; fixation plates
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Joaquim Ciurana Gay

E-Mail Website
Guest Editor
Department of Mechanical Engineering and Civil Construction, Universitat de Girona, Girona, Spain
Interests: mechanical design; biomedical engineering; mechanical engineering; biomechanical engineering; CAD; machine tools; manufacturing engineering; manufacturing systems; machining; manufacturing process mechanics; mechanical processes; additive manufacturing; industrial engineering; artificial neural networks
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Arantxa Eceiza Mendiguren

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Guest Editor
Materials + Technologies Research Group (GMT), Department of Chemical and Environmental Engineering, Faculty of Engineering of Gipuzkoa, University of Basque Country, Plz. Europa 1, 20018 Donostia-San Sebastian, Spain
Interests: polyurethanes; valorization of biomass-derived products; biobased polymers; (nano)composites; nanocrystals from polysaccharides; advanced processing technologies; functional polymers; smart materials
Special Issues, Collections and Topics in MDPI journals
Dr. Luís Jesús Quiles Carrillo

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Guest Editor
Technological Institute of Materials (ITM), Universitat Politècnica de València (UPV), Valencia, Spain
Interests: polymer processing; biobased and biodegradable polymers; wood plastic composites; mechanical and thermal characterization; biodegradation; green composites; advanced characterization; functional additives
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Additive manufacturing (AM) has found one of its most innovative and versatile applications in the field of healthcare. The application of AM in medical applications is bursting, and these emerging technologies innovations will define the healthcare of the future. AM technologies are currently not only used to manufacture prototypes for training, simulation, and presurgical planning of complex surgical procedures, but also to produce customized prosthetics and medical tools. However, these applications are only the first step, and materials and manufacturing processes for 3D printing for medical applications are in a continuous, complex state of evolution due to the material–process­–property–functionality relationship.

This Special Issue seeks to present original articles, review articles, and state-of-the-art research papers that focus on:

  • Research, development, and standardization of materials suitable for medical additive manufacturing;
  • Frontier technological and progress research of medical additive manufacturing;
  • Research on clinical translation and application of medical additive manufacturing.

We kindly invite you to submit a manuscript(s) for this Special Issue. Full papers, communications, and reviews are all welcome.

Prof. Dr. Rafael Antonio Balart Gimeno
Dr. Teodomiro Boronat Vitoria
Prof. Dr. Joaquim De Ciurana Gay
Prof. Dr. Arantxa Eceiza Mendiguren
Dr. Luís Jesús Quiles-Carrillo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Additive manufacturing technologies
  • Biocompatible materials
  • Medical implants
  • Customized prosthetics
  • Resorbable polymers
  • Biocompatible organic and inorganic additives
  • Controlled drug release
  • Advanced characterization
  • Hydrogels, polyesters, polyurethanes, polydioxanone, and other polymers in medicine
  • Bioprinting
  • Electrospinning
  • Scaffolds, stents, tissue engineering, fixation plates, screws, bone implants, and so on
  • Protein-based polymers
  • Surface modification, wettability
  • Computer modeling
  • Biocompatibility studies

Published Papers (3 papers)

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Research

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13 pages, 6722 KiB  
Article
Design of a Waterborne Polyurethane–Urea Ink for Direct Ink Writing 3D Printing
by Julen Vadillo, Izaskun Larraza, Tamara Calvo-Correas, Nagore Gabilondo, Christophe Derail and Arantxa Eceiza
Materials 2021, 14(12), 3287; https://doi.org/10.3390/ma14123287 - 14 Jun 2021
Cited by 18 | Viewed by 2536
Abstract
In this work, polycaprolactone–polyethylene glycol (PCL–PEG) based waterborne polyurethane–urea (WBPUU) inks have been developed for an extrusion-based 3D printing technology. The WBPUU, synthesized from an optimized ratio of hydrophobic polycaprolactone diol and hydrophilic polyethylene glycol (0.2:0.8) in the soft segment, is able to [...] Read more.
In this work, polycaprolactone–polyethylene glycol (PCL–PEG) based waterborne polyurethane–urea (WBPUU) inks have been developed for an extrusion-based 3D printing technology. The WBPUU, synthesized from an optimized ratio of hydrophobic polycaprolactone diol and hydrophilic polyethylene glycol (0.2:0.8) in the soft segment, is able to form a physical gel at low solid contents. WBPUU inks with different solid contents have been synthesized. The rheology of the prepared systems was studied and the WBPUUs were subsequently used in the printing of different pieces to demonstrate the relationship between their rheological properties and their printing viability, establishing an optimal window of compositions for the developed WBPUU based inks. The results showed that the increase in solid content results in more structured inks, presenting a higher storage modulus as well as lower tan δ values, allowing for the improvement of the ink’s shape fidelity. However, an increase in solid content also leads to an increase in the yield point and viscosity, leading to printability limitations. From among all printable systems, the WBPUU with a solid content of 32 wt% is proposed to be the more suitable ink for a successful printing performance, presenting both adequate printability and good shape fidelity, which leads to the realization of a recognizable and accurate 3D construct and an understanding of its relationship with rheological parameters. Full article
(This article belongs to the Special Issue Advanced Materials in Additive Manufacturing for Medical Applications)
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9 pages, 1492 KiB  
Communication
Anatase Titanium Dioxide Imparts Photoluminescent Properties to PA2200 Commercial 3D Printing Material to Generate Complex Optical Imaging Phantoms
by Tyler Dann, Jordan Raphel, Seth T. Gammon, Zachary Mastrovich, Tony Van Avermaete, Justin Jeffrey, Satish Adusumilli and W. Matthew Leevy
Materials 2021, 14(7), 1813; https://doi.org/10.3390/ma14071813 - 06 Apr 2021
Cited by 3 | Viewed by 2281
Abstract
Selective laser sintering (SLS) is a prominent 3D printing modality that typically uses a polyamide (PA) powder as the substrate. One commercially available SLS material is known as PA2200, which is comprised of nylon 12 and titanium dioxide (TiO2) and is [...] Read more.
Selective laser sintering (SLS) is a prominent 3D printing modality that typically uses a polyamide (PA) powder as the substrate. One commercially available SLS material is known as PA2200, which is comprised of nylon 12 and titanium dioxide (TiO2) and is widely used to generate 3D-printed parts. Here, we report a unique optical photoluminescence (PL) characteristic of native, white PA2200, in which it yields a persistent, phosphorescence-type emission. An analysis of luminescence imaging data with emission measurements demonstrated that the anatase phase of the titanium dioxide additive is the source of the persistent PL properties. This characteristic of PA2200 enables advanced optical imaging applications, as demonstrated by luminescence imaging of an anatomical rat skeleton and a novel Derenzo-type phantom on a commercial image station. In summary, the light emission properties of PA2200 induced by the presence of anatase titanium dioxide open the door to a vast new array of complex optical applications, including the generation of imaging phantoms for training, calibration, and quality control. Full article
(This article belongs to the Special Issue Advanced Materials in Additive Manufacturing for Medical Applications)
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Review

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22 pages, 2027 KiB  
Review
Cardiovascular Stents: A Review of Past, Current, and Emerging Devices
by Alexandru Scafa Udriște, Adelina-Gabriela Niculescu, Alexandru Mihai Grumezescu and Elisabeta Bădilă
Materials 2021, 14(10), 2498; https://doi.org/10.3390/ma14102498 - 12 May 2021
Cited by 51 | Viewed by 6625
Abstract
One of the leading causes of morbidity and mortality worldwide is coronary artery disease, a condition characterized by the narrowing of the artery due to plaque deposits. The standard of care for treating this disease is the introduction of a stent at the [...] Read more.
One of the leading causes of morbidity and mortality worldwide is coronary artery disease, a condition characterized by the narrowing of the artery due to plaque deposits. The standard of care for treating this disease is the introduction of a stent at the lesion site. This life-saving tubular device ensures vessel support, keeping the blood-flow path open so that the cardiac muscle receives its vital nutrients and oxygen supply. Several generations of stents have been iteratively developed towards improving patient outcomes and diminishing adverse side effects following the implanting procedure. Moving from bare-metal stents to drug-eluting stents, and recently reaching bioresorbable stents, this research field is under continuous development. To keep up with how stent technology has advanced in the past few decades, this paper reviews the evolution of these devices, focusing on how they can be further optimized towards creating an ideal vascular scaffold. Full article
(This article belongs to the Special Issue Advanced Materials in Additive Manufacturing for Medical Applications)
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