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Advanced Materials for Biomedical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 2010

Special Issue Editors


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Institute of Nanoscience and Nanotechnology, Building No 8, NCSR Demokritos, Neapoleos 27 & Patriarch Grigoriou E Street, Agia Paraskevi, 15341 Athens, Greece
Interests: surface chemistry; membranes; nanotechnology; renewable energy; environmental chemistry; physical chemistry
Special Issues, Collections and Topics in MDPI journals

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Polymerization Processes, Centro de Investigacion en Quimica Aplicada, Saltillo 25294, Mexico
Interests: heterophase polymerization; microemulsions; nanodevices; polymeric drug carriers; inorganic heterostructures; cancer treatment

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Guest Editor
Department of Chemical Engineering, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78300, Mexico
Interests: green synthesis; nanotechnology; heterostructures; nanodevices; environmental chemistry

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Guest Editor
Department of Microbiology, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78300, Mexico
Interests: antimicrobial resistance; clinical biofilm; medical devices; microbiota modulation; cellular cytotoxicity

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Guest Editor
Center for Research in Applied Chemistry, Blvd. Enrique Reyna Hermosillo 140, Saltillo 25294, Mexico
Interests: nanodevices; nanoparticles; hydrogels; drug delivery; anticancer agents delivery; antibiotic delivery

Special Issue Information

Dear Colleagues,

Interdisciplinary research in the field of front-line materials in biomedical applications continues to attract the attention of pharmacists, biologists, chemists, materials scientists, engineers, clinicians and other researchers worldwide. Some areas of investigation include the development of advanced materials, i.e., smart polymers, nanostructures, hybrid materials (e.g., inorganic/organic materials), microemulsions, hydrogels, liposomes, etc. The application of these materials in the biomedical field encompasses, but is not limited to, wound healing, imaging, targeted drug delivery, scaffolds, medical devices, tissue engineering, controlled release, cancer treatment and the specific delivery of drugs for cardiovascular disease, among others.

In this Special Issue we intend to present research outcomes reporting current findings on advanced materials for biomedical applications considering their performance, healing properties and the well-being of the patients who could benefit from these cutting-edge technologies under development. The published reports are expected to inspire future research on these most exciting materials. The editorial team for this Special Issue invites contributions about novel and innovative advanced materials with applications in medicine and pharmacy as well as innovative or modified analytical techniques associated with these materials, in the form of original research articles, reviews, research notes and short communications from the scientific community.

Dr. Ioannis Liakos
Dr. René D. Darío Peralta-Rodríguez
Dr. Esmeralda Mendoza
Dr. Fidel Martinez-Gutierrez
Dr. Héctor Iván Meléndez Ortíz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • smart polymers
  • nanostructures
  • hydrogels
  • drug nanocarriers
  • nano- and microdevices
  • biopolymers
  • drug delivery
  • organic/inorganic hybrid materials
  • pharmaceutical applications

Published Papers (2 papers)

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Research

18 pages, 3963 KiB  
Article
Synthesis and In Vitro Biocompatibility Studies of Novel Alkoxy 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacenes
by Margarida G. Santos, Juliana Araújo, Chrislaura Carmo, Leonardo Santos, Maria Filomena Botelho, Mafalda Laranjo and Abílio J. F. N. Sobral
Materials 2023, 16(22), 7085; https://doi.org/10.3390/ma16227085 - 08 Nov 2023
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Abstract
BODIPYs are bicyclic aromatic compounds with unique spectroscopic, photophysical, and chemical properties. This study aimed to find BODIPYs with characteristics biocompatible with human cell lines for possible use as imaging agents. Six BODIPY derivatives were synthesised with groups linked to boron, fluorine, phenol, [...] Read more.
BODIPYs are bicyclic aromatic compounds with unique spectroscopic, photophysical, and chemical properties. This study aimed to find BODIPYs with characteristics biocompatible with human cell lines for possible use as imaging agents. Six BODIPY derivatives were synthesised with groups linked to boron, fluorine, phenol, or catechol, resulting in compounds with different physicochemical characteristics. NMR, absorption, and emission spectroscopy and mass spectrometry were subsequently used to characterise them. Afterwards, the biocompatibility of these compounds was evaluated using MTT, SRB, and cellular uptake assays in A549 and H1299 cell lines. Furthermore, a haemolysis assay was performed on human blood cells. To summarise the main results, BODIPYs 1 to 4 showed considerable fluorescence. In contrast, BODIPYs 5 and 6 showed very weak fluorescence, which could be related to the presence of the catechol group and its quenching properties. Regarding biocompatibility, all compounds had metabolic activity and viability above 80% and 70%, respectively. BODIPYs 3 and 6 presented the most consistent data, demonstrating good uptake and, in general, haemolytic activity below 25%. In conclusion, the cytotoxic effects of the compounds were not considerable, and the presence of cyclic alkoxides in BODIPYs 3 and 6 may introduce exciting features that should be highlighted for dual imaging for BODIPY 3 due to its fluorescence or for radioactive labelling in the case of both BODIPYs. Full article
(This article belongs to the Special Issue Advanced Materials for Biomedical Applications)
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13 pages, 2634 KiB  
Article
Effect of Sodium Hydroxide and Tripolyphosphate on Curcumin Release from Chitosan-Based Macroparticles
by Alessandro Pistone, Annamaria de Gaetano, Elpida Piperopoulos and Chiara Abate
Materials 2023, 16(17), 5850; https://doi.org/10.3390/ma16175850 - 26 Aug 2023
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Abstract
This work deals with the synthesis of bare and curcumin (CUR)-loaded chitosan (CS)-based macroparticles by ionic gelation using sodium hydroxide (NaOH) or sodium tripolyphosphate (TPP). The resulting spherical-shaped macroparticles were studied using various characterization techniques, Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy [...] Read more.
This work deals with the synthesis of bare and curcumin (CUR)-loaded chitosan (CS)-based macroparticles by ionic gelation using sodium hydroxide (NaOH) or sodium tripolyphosphate (TPP). The resulting spherical-shaped macroparticles were studied using various characterization techniques, Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), and Differential Scanning Calorimetry (DSC). The release of CUR from the CS-based particles with respect to time was analyzed, and the encapsulation efficiency and degree of swelling were studied. All formulations showed excellent CUR trapping efficiency, exceeding 90%. In particular, the TPP-crosslinked macrobeads released 34 wt% of the charged CUR within minutes, while the remaining 66 wt% was released slowly. The results indicate that the correct choice of gelling agent and its concentration leads to spherical particles capable of encapsulating CUR and releasing it in a wide range of kinetics so that macrospheres can be used in different applications. Full article
(This article belongs to the Special Issue Advanced Materials for Biomedical Applications)
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