Special Issue "Bioactive Metabolites Produced by Marine Cyanobacteria and Other Microalgae"

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 18 October 2024 | Viewed by 1576

Special Issue Editors

Division of Marine Biotechnology, Institute of Oceanography, University of Gdańsk, Marszałka J. Piłsudskiego 46, PL-81378 Gdynia, Poland
Interests: natural products; marine drugs; cytotoxicity, antiviral agents; nonribosomal peptides; structure and activity; cyanobacteria toxins; peptidomics
Special Issues, Collections and Topics in MDPI journals
Division of Marine Biotechnology, Institute of Oceanography, University of Gdańsk, , Marszałka J. Piłsudskiego 46, PL-81378 Gdynia, Poland
Interests: marine microbes; bioactive natural products; marine drugs; nonribosomal peptides; antibacterial activity; molecular ecology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Although secondary metabolites produced by marine cyanobacteria and other microalgae have been explored for over fifty years, they still attract the attention of many research groups. A significant number of the compounds showed some effects on other organisms and were proven to be active against different cellular targets. Toxic and anticancer effects and activity against important metabolic enzymes are the most commonly reported. With the growing awareness of the risk of infectious diseases, an increased interest in antimicrobial and antiviral potential of the compounds can also be observed.

Due to the diverse biological activities of the metabolites produced by marine cyanobacteria and microalgae, the pharmaceutical and biotechnological potential of these organisms is widely explored. What may seem surprising, however, is that the role of the metabolites in the life of the producing microorganisms usually remains unknown.

We invite authors to contribute to this Special Issue by submitting original research articles or review papers on all aspects of bioactive metabolites produced by marine cyanobacteria and other microalgae. This could include structural analysis, studies of activity and mechanism of action, characterization of biosynthetic gene clusters, ecological significance and potential pharmaceutical and biotechnological applications of the metabolites.

Prof. Dr. Hanna Mazur-Marzec
Dr. Anna Toruńska-Sitarz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cyanobacteria
  • microalgae
  • natural products
  • secondary metabolites
  • genome mining
  • extraction and isolation
  • structural analysis
  • biological activity
  • molecular targets
  • pharmaceutical application
  • biotechnological potential
  • toxicity

Published Papers (1 paper)

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Research

19 pages, 5983 KiB  
Article
Structural Diversity and Biological Activity of Cyanopeptolins Produced by Nostoc edaphicum CCNP1411
Mar. Drugs 2023, 21(10), 508; https://doi.org/10.3390/md21100508 - 26 Sep 2023
Viewed by 1571
Abstract
Cyanopeptolins (CPs) are one of the most commonly occurring class of cyanobacterial nonribosomal peptides. For the majority of these compounds, protease inhibition has been reported. In the current work, the structural diversity of cyanopeptolins produced by Nostoc edaphicum CCNP1411 was explored. As a [...] Read more.
Cyanopeptolins (CPs) are one of the most commonly occurring class of cyanobacterial nonribosomal peptides. For the majority of these compounds, protease inhibition has been reported. In the current work, the structural diversity of cyanopeptolins produced by Nostoc edaphicum CCNP1411 was explored. As a result, 93 CPs, including 79 new variants, were detected and structurally characterized based on their mass fragmentation spectra. CPs isolated in higher amounts were additionally characterized by NMR. To the best of our knowledge, this is the highest number of cyanopeptides found in one strain. The biological assays performed with the 34 isolated CPs confirmed the significance of the amino acid located between Thr and the unique 3-amino-6-hydroxy-2-piperidone (Ahp) on the activity of the compounds against serine protease and HeLa cancer cells. Full article
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