Marine Linear Peptides: Isolation, Structure, Biological Properties, Synthesis, Biosynthesis, and Current Advances in Therapeutics
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 9081
Special Issue Editor
Interests: marine natural product chemistry; marine sponges; marine microbiology; marine chemical ecology; bioactivity; antifouling, anti-biofilm compounds
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The extraordinary biodiversity of the marine world has already offered thousands of varied compounds, such as steroids and terpenoids, alkaloids, polyketides, peptides, etc. The latter represent a large family of marine compounds with a broad spectrum of properties ranging from anticancer to antimicrobial, antioxidant, and anti-inflammatory activities. Marine linear peptides have been particularly successful, leading to two marketed drugs, ziconotide (Prialt®) and Brentuximab vedotin (Adcetris®).
Ziconotide, also known as ω-conotoxin MVIIA, is a 25 amino acid peptide with three disulfide linkages that was clinically approved by the US Food and Drug Administration (FDA) in December 2004 for the intrathecal treatment of severe chronic pain. Ziconotide was shown to block the entry of calcium into neuronal N-type voltage-sensitive calcium channels.
Brentuximab vedotin, a peptide-derived from dolastatin-10 analogue (monomethyl auristatin E), belongs to the very exciting anticancer class of antibody–drug conjugates (ADCs). Brentuximab vedotin is used for the treatment of relapsed or refractory CD30-positive Hodgkin's lymphoma. So far, five other ADCs have been marketed and 16 ADCs are in clinical trials, at various stages of development. They represent an extremely promising avenue for new molecules with potential anticancer activities.
More recently, gallinamide A, an unusual linear peptide isolated from marine cyanobacteria, known as a potent and selective inhibitor of human cathepsin L, revealed anti-SRAS-CoV2 activity with EC50 values in the nanomolar range.
These successful and growing promises of linear peptides in human therapies have led us to propose a Special Issue entitled “Marine Linear Peptides” to showcase the remarkable family of linear peptides from marine macroorganisms and microorganisms such as cyanobacteria and actinomycetes, including the innovative methodologies used for their identifications, as well as their biological properties and synthesis or biosynthesis. Their potential applications as pharmaceuticals or nutraceuticals will be developed. The progression of some peptide-derived products to clinical trial development should provide to the marine scientist community exciting recent information regarding these attractive families of natural products.
Dr. Marie-Lise Bourguet-Kondracki
Guest Editor
Manuscript Submission Information
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Keywords
- Marine linear peptides
- Conotoxin
- Marine cyanobacteria
- Marine actinomycetes
- Biological activity
- Pharmaceuticals
- Nutraceuticals
- Marine natural products
