Special Issue "Conotoxin and Conotoxin Analogues: A Pharmacy Cabinet under the Sea"
Deadline for manuscript submissions: 25 November 2023 | Viewed by 5940
Interests: peptide synthesis; bioactive peptides; disulphide mimetics; alkene and alkyne metathesis; green chemistry; sustainability
The venom of marine cone snails contains a plethora of peptides with exquisite activity. These peptides, known as conotoxins, are short peptides with multiple disulphide bridges in a varied framework that constrains their structure. They also usually bear post-translational modifications such as the amidation of the C-terminus, the cyclisation of an N-terminal glutamine residue into pyroglutamic acid as well as hydroxylation, bromination, γ-carboxylation, and sulfation. Conotoxins interact with human ion channels, G-protein coupled receptors, and transporters in the nervous system which makes them appealing drug candidates.
Recent advances have been made in the understanding of the interactions between GABAB receptors and a-conotoxins. The mode of action of many other conotoxins is still elusive; however, a clear understanding is crucial for the design of analogues that are robust candidates in clinical trials and that can ultimately be developed as drugs.
This Special Issue invites contributions on the following topics: the identification and characterisation of novel conotoxins and synthesis of novel conotoxin analogues or small molecule mimetics with an improved pharmacological profile that can contribute to the understanding of the mechanism of action.
Dr. Alessia Belgi
Prof. Dr. Andrea Jane Robinson
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- conotoxin analogue
- novel conotoxin
- conotoxin mimetic
- mode of action