Special Issue "Tetrodotoxins: Detection, Biosynthesis and Biological Effects"
Deadline for manuscript submissions: 21 December 2023 | Viewed by 6116
Interests: bioanalysis; biomolecules; biotoxins; bioactive compounds; marine biotechnology; valorization of marine bioresources; analytical chemistry; mass spectrometry; chromatography
Tetrodotoxin (TTX) is a heat-stable, highly hydrophilic and potent neurotoxin mainly found in marine organisms, such as pufferfish, toadfish, gastropods and crabs. About 1–4 mg of this toxin can be lethal to humans, and several cases of TTX intoxication are reported every year, especially in East Asia, where consumption of certain pufferfish species is relatively high. Endosymbiotic bacteria are generally considered to be the primary source of TTX, but the exact processes/factors shaping the biosynthesis, regulation and accumulation of TTX remain unclear. Given the risk to public health, there is increasing interest in measuring TTX levels in pufferfish and other edible marine organisms (e.g., oysters, scallops). Since this toxin has been found to coexist with almost 30 structural analogues of varying toxicity, there is also interest in assessing the profile of individual analogues rather than TTX alone. Over the last decade, comprehensive analysis of TTXs has become less challenging due to the advent of robust columns for hydrophilic interaction liquid chromatography (HILIC) and the development of mass-spectrometry-based detection methods. However, alternative techniques enabling rapid, sensitive, inexpensive or on-the-spot screening are also needed.
The aim of this Special Issue is to gather the most recent research on the detection, biosynthesis and biological effects of tetrodotoxin. All papers dealing with novel detection tools, toxic effects, additional unexplored bioactivities, biological synthesis, regulation, accumulation, occurrence of TTX in aquatic organisms and relevant microbiological studies are welcome.
Dr. Manolis Mandalakis
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- occurrence and levels of tetrodotoxin
- detection and quantification
- analytical methods
- biosynthetic processes