Marine Natural Products with Anti-obesity and Antidiabetic Potentials

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: closed (1 March 2024) | Viewed by 1505

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Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Durban 4000, South Africa
Interests: Type 2 diabetes; obesity; animal model; nutrition; functional foods; medicinal foods; medicinal plants; artificial sweeteners; natural sweeteners
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Special Issue Information

Dear Colleagues,

Obesity and diabetes represent serious threats to the global health system due to their rapid increase in prevalence all over the world. Projections suggest that the current number of overweight and obese people will double by 2030. Additionally, obesity is one of the major causal factors for the development of insulin resistance as well as type 2 diabetes, hence the term ‘diabesity’, which refers to the occurrence of diabetes as a result of obesity. ‘Diabesity’ is associated with the development and progression of other noncommunicable diseases, including but not limited to cardiovascular disease, hypertension, and stroke. There are a number of oral medicines available for obesity and diabetes; however, none of these are without side effects, and all need to be used in conjunction with being physically active and consuming a healthy balanced diet. Almost all these conventional medicines are also not affordable for people in underdeveloped and developing countries. Hence, the demand for natural anti-obesity and antidiabetic medicines has increased in the recent years due to their fewer or no side effects and lower cost. A large number of marine algae on the coastline goes to waste with no valuable use, although there are reports on the potential anti-obesity and antidiabetes activities of marine algae and their bioactive compounds.

Hence, you are invited to submit your original or review articles based on the anti-obesity and antidiabetes effects of marine algae, and their isolated bioactive compounds which were developed based on the in vitro, ex vivo, in vivo (animal model) and clinical trials, and their mechanism of actions behind the biological effects.

Prof. Dr. Md. Shahidul Islam
Guest Editor

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Published Papers (1 paper)

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Research

18 pages, 2103 KiB  
Article
Anti-Obesity Effects of Marine Macroalgae Extract Caulerpa lentillifera in a Caenorhabditis elegans Model
by Kawita Chumphoochai, Preeyanuch Manohong, Nakorn Niamnont, Montakan Tamtin, Prasert Sobhon and Krai Meemon
Mar. Drugs 2023, 21(11), 577; https://doi.org/10.3390/md21110577 - 03 Nov 2023
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Abstract
Obesity is a multifactorial disease characterized by an excessive accumulation of fat, which in turn poses a significant risk to health. Bioactive compounds obtained from macroalgae have demonstrated their efficacy in combating obesity in various animal models. The green macroalgae Caulerpa lentillifera (CL) [...] Read more.
Obesity is a multifactorial disease characterized by an excessive accumulation of fat, which in turn poses a significant risk to health. Bioactive compounds obtained from macroalgae have demonstrated their efficacy in combating obesity in various animal models. The green macroalgae Caulerpa lentillifera (CL) contains numerous active constituents. Hence, in the present study, we aimed to elucidate the beneficial anti-obesity effects of extracts derived from C. lentillifera using a Caenorhabditis elegans obesity model. The ethanol (CLET) and ethyl acetate (CLEA) extracts caused a significant decrease in fat consumption, reaching up to approximately 50–60%. Triglyceride levels in 50 mM glucose-fed worms were significantly reduced by approximately 200%. The GFP-labeled dhs-3, a marker for lipid droplets, exhibited a significant reduction in its level to approximately 30%. Furthermore, the level of intracellular ROS displayed a significant decrease of 18.26 to 23.91% in high-glucose-fed worms treated with CL extracts, while their lifespan remained unchanged. Additionally, the mRNA expression of genes associated with lipogenesis, such as sbp-1, showed a significant down-regulation following treatment with CL extracts. This finding was supported by a significant decrease (at 16.22–18.29%) in GFP-labeled sbp-1 gene expression. These results suggest that C. lentillifera extracts may facilitate a reduction in total fat accumulation induced by glucose through sbp-1 pathways. In summary, this study highlights the anti-obesity potential of compounds derived from C. lentillifera extracts in a C. elegans model of obesity, mediated by the suppression of lipogenesis pathways. Full article
(This article belongs to the Special Issue Marine Natural Products with Anti-obesity and Antidiabetic Potentials)
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