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Special Issue "Natural Products Isolated from Marine Sediment"

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A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 March 2024 | Viewed by 2021

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Special Issue Editor

Dr. Jie Bao

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Guest Editor

School of Biological Science and Technology, University of Jinan, Jinan, China
Interests: natural products; marine fungi; biological activity

Special Issue Information

Dear Colleagues,

Marine sediments are mainly attached to the intertidal zone, the rhizosphere soil from mangrove plants or seaweed, and the seafloor sediments. They possess complex microbial communities related to fungi, bacteria, and archaea, which play important roles in the degradation and mineralization of organic matter in the marine environment, as well as in the biogeochemical cycling of elements such as carbon, nitrogen, phosphorus, and sulfur.

Additionally, microorganisms derived from marine sediments can produce structurally diverse metabolites, including polyketides, alkaloids, peptides, terpenes, and others, showing significant biological activities such as cytotoxic, antibacterial, anti-inflammatory, antiviral, and insecticidal properties. In recent years, extensive research on natural products from marine sediments has been conducted, and mainly centered on fungi and actinomyces, providing promising application prospects in drug development, agricultural production, and industrial applications.

This Special Issue focuses on natural products derived from marine sediment, concerning their structural identification, biological activities, pharmaceutical mechanisms, chemical synthesis, or biosynthesis. In addition, submissions on new methods or technologies for the analysis of microbial metabolites or their biological activities are also welcome.

Here, we invite you to submit manuscripts on recent studies or reviews highlighting natural products derived from marine sediment, especially ones resulting from microorganisms.

Dr. Jie Bao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

natural products
secondary metabolites
marine sediments
mangrove sediment
biological activity
microorganism

Published Papers (3 papers)

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Research

14 pages, 2828 KiB

Open AccessArticle

Indole Diterpenes from Mangrove Sediment-Derived Fungus Penicillium sp. UJNMF0740 Protect PC12 Cells against 6-OHDA-Induced Neurotoxicity via Regulating the PI3K/Akt Pathway

and

Mar. Drugs 2023, 21(11), 593; https://doi.org/10.3390/md21110593 - 14 Nov 2023

Viewed by 526

Abstract

In our chemical investigation into Penicillium sp. UJNMF0740 derived from mangrove sediment, fourteen indole diterpene analogs, including four new ones, are purified by multiple chromatographic separation methods, with their structures being elucidated by the analyses of NMR, HR-ESIMS, and ECD data. The antibacterial and neuroprotective effects of these isolates were examined, and only compounds 6 and 9 exhibited weak antibacterial activity, while compounds 5, 8, and 10 showed protective effects against the injury of PC12 cells induced by 6-hydroxydopamine (6-OHDA). Additionally, compound 5 could suppress the apoptosis and production of reactive oxygen species (ROS) in 6-OHDA-stimulated PC12 cells as well as trigger the phosphorylation of PI3K and Akt. Taken together, our work enriches the structural diversity of indole diterpenes and hints that compounds of this skeleton can repress the 6-OHDA-induced apoptosis of PC12 cells via regulating the PI3K/Akt signaling pathway, which provides evidence for the future utilization of this fascinating class of molecules as potential neuroprotective agents. Full article

(This article belongs to the Special Issue Natural Products Isolated from Marine Sediment)

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21 pages, 4781 KiB

Open AccessArticle

New Cyclopiane Diterpenes and Polyketide Derivatives from Marine Sediment-Derived Fungus Penicillium antarcticum KMM 4670 and Their Biological Activities

Anatoly I. Kalinovsky

Dmitry V. Berdyshev

Natalya Y. Kim

Roman S. Popov

Ekaterina A. Chingizova

Artur R. Chingizov

Marina P. Isaeva

and

Ekaterina A. Yurchenko

Mar. Drugs 2023, 21(11), 584; https://doi.org/10.3390/md21110584 - 09 Nov 2023

Viewed by 628

Abstract

Two new cyclopiane diterpenes and a new cladosporin precursor, together with four known related compounds, were isolated from the marine sediment-derived fungus Penicillium antarcticum KMM 4670, which was re-identified based on phylogenetic inference from ITS, BenA, CaM, and RPB2 gene regions. The absolute stereostructures of the isolated cyclopianes were determined using modified Mosher’s method and quantum chemical calculations of the ECD spectra. The isolation from the natural source of two biosynthetic precursors of cladosporin from a natural source has been reported for the first time. The antimicrobial activities of the isolated compounds against Staphylococcus aureus, Escherichia coli, and Candida albicans as well as the inhibition of staphylococcal sortase A activity were investigated. Moreover, the cytotoxicity of the compounds to mammalian cardiomyocytes H9c2 was studied. As a result, new cyclopiane diterpene 13-epi-conidiogenone F was found to be a sortase A inhibitor and a promising anti-staphylococcal agent. Full article

(This article belongs to the Special Issue Natural Products Isolated from Marine Sediment)

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14 pages, 1412 KiB

Open AccessArticle

Lecanicilliums A–F, Thiodiketopiperazine-Class Alkaloids from a Mangrove Sediment-Derived Fungus Lecanicillium kalimantanense

and

Mar. Drugs 2023, 21(11), 575; https://doi.org/10.3390/md21110575 - 31 Oct 2023

Viewed by 711

Abstract

Six new thiodiketopiperazine-class alkaloids lecanicilliums A–F were isolated from the mangrove sediment-derived fungus Lecanicillium kalimantanense SCSIO41702, together with thirteen known analogues. Their structures were determined by spectroscopic analysis. The absolute configurations were determined by quantum chemical calculations. Electronic circular dichroism (ECD) spectra and the structure of Lecanicillium C were further confirmed by a single-crystal X-ray diffraction analysis. Lecanicillium A contained an unprecedented 6/5/6/5/7/6 cyclic system with a spirocyclic center at C-2′. Biologically, lecanicillium E, emethacin B, and versicolor A displayed significant cytotoxicity against human lung adenocarcinoma cell line H1975, with IC₅₀ values of 7.2~16.9 μM, and lecanicillium E also showed antibacterial activity against four pathogens with MIC values of 10~40 μg/mL. Their structure–activity relationship is also discussed. Full article

(This article belongs to the Special Issue Natural Products Isolated from Marine Sediment)

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