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Marine Drugs
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Commemorating the Launch of the Section “Marine-Derived Ingredients for Drugs,...
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Commemorating the Launch of the Section “Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals”

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: closed (25 June 2023) | Viewed by 6764

Special Issue Editors

Prof. Dr. Yue-Wei Guo

E-Mail Website
Guest Editor
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Interests: marine fauna and flora; chemistry and bioactivity of natural products; marine chemoecology; marine drug research
Prof. Dr. Yuming Wang

E-Mail Website
Guest Editor
College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China
Interests: marine functional lipids; brain function; lipid metabolism; metabolism syndrome
Special Issues, Collections and Topics in MDPI journals
Dr. Munish Puri

E-Mail Website
Guest Editor
Centre for Marine Bioproducts Development, College of Medicine & Public Health, Flinders University, Adelaide, SA, Australia
Interests: algal biotechnology; bioprocessing; marine bioactives; downstream processing; omega-3; carotenoids; proteins; enzymes; nanotechnology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

‘Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals’, a new section of Marine Drugs (ISSN: 1660-3397), was launched in April 2022. This section aims to publish papers on the application of marine-derived ingredients and bioproducts as cosmeceuticals, nutraceuticals, functional foods, and nutritional supplements. We welcome the submission of high-quality research on the science of marine-derived ingredients for drugs, cosmeceuticals, and nutraceuticals.

We have also established a new Special Issue to commemorate the launch of “Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals”. It is our pleasure to invite you to submit your manuscripts for publication in this Special Issue.

The Special Issue is devoted to recent research in marine nutraceuticals furthering our understanding of the requirements and benefits of nutraceutical supplementation, cost-effective production of bioactives, use of innovative technologies in extracting and stabilising marine bioactives, and their application as functional food.

Prof. Dr. Yue-Wei Guo
Prof. Dr. Yuming Wang
Dr. Munish Puri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine bioactives
  • nutraceuticals
  • functional foods
  • macroalgae
  • seaweed
  • carotenoids
  • fucoxanthin
  • single cell oils
  • nutrition

Published Papers (4 papers)

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Research

14 pages, 1971 KiB  
Article
Repair and Mechanism of Oligopeptide SEP-3 on Oxidative Stress Liver Injury Induced by Sleep Deprivation in Mice
by Xin Hou, Chong Yi, Zekun Zhang, Hui Wen, Yufeng Sun, Jiaxin Xu, Hongyu Luo and Tao Yang
Mar. Drugs 2023, 21(3), 139; https://doi.org/10.3390/md21030139 - 22 Feb 2023
Cited by 1 | Viewed by 1374
Abstract
To investigate the effects of bonito oligopeptide SEP-3 on the repair of liver damage and regulation of liver biorhythm in sleep-deprived mice (SDM), C57BL/6 male mice were subjected to sleep deprivation by modified multi-platform water environment method, and were given different doses of [...] Read more.
To investigate the effects of bonito oligopeptide SEP-3 on the repair of liver damage and regulation of liver biorhythm in sleep-deprived mice (SDM), C57BL/6 male mice were subjected to sleep deprivation by modified multi-platform water environment method, and were given different doses of bonito oligopeptide SEP-3 in groups. To determine the liver organ index, liver tissue-related apoptotic protein levels, Wnt/β-Catenin pathway-related protein expression levels, serum alanine transaminase (ALT), glutamicum transaminase (AST), glucocorticoid (GC), and adrenocorticotropin (ACTH) content in each group of mice, four time points were selected to examine the mRNA expression levels of circadian clock-related genes in mouse liver tissue. The results showed that low, medium, and high doses of SEP-3 significantly increased SDM, ALT, and AST (p < 0.05), and medium and high doses of SEP-3 significantly reduced SDM liver index and GC and ACTH. As SEP-3 increased the apoptotic protein and Wnt/β-Catenin pathway, mRNA expression gradually tended to normal (p < 0.05). This suggests that sleep deprivation can cause excessive oxidative stress in mice, which can lead to liver damage. Additionally, oligopeptide SEP-3 achieves the repair of liver damage by inhibiting SDM hepatocyte apoptosis, activating liver Wnt/β-Catenin pathway, and promoting hepatocyte proliferation and migration, and suggests that oligopeptide SEP-3 is closely related to repair of liver damage by regulating the biological rhythm of SDM disorder. Full article
(This article belongs to the Special Issue Commemorating the Launch of the Section “Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals”)
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15 pages, 2563 KiB  
Article
Construction of Glucose-6-Phosphate Dehydrogenase Overexpression Strain of Schizochytrium sp. H016 to Improve Docosahexaenoic Acid Production
by Yumei Feng, Yuanmin Zhu, Zhendong Bao, Bohan Wang, Tingting Liu, Huihui Wang, Tianyi Yu, Ying Yang and Longjiang Yu
Mar. Drugs 2023, 21(1), 17; https://doi.org/10.3390/md21010017 - 26 Dec 2022
Cited by 2 | Viewed by 1720
Abstract
Docosahexaenoic acid (DHA) is an important omega-3 polyunsaturated fatty acid (PUFA) that plays a critical physiological role in human health. Schizochytrium sp. is considered an excellent strain for DHA production, but the synthesis of DHA is limited by the availability of nicotinamide adenine [...] Read more.
Docosahexaenoic acid (DHA) is an important omega-3 polyunsaturated fatty acid (PUFA) that plays a critical physiological role in human health. Schizochytrium sp. is considered an excellent strain for DHA production, but the synthesis of DHA is limited by the availability of nicotinamide adenine dinucleotide phosphate (NADPH). In this study, the endogenous glucose-6-phosphate dehydrogenase (G6PD) gene was overexpressed in Schizochytrium sp. H016. Results demonstrated that G6PD overexpression increased the availability of NADPH, which ultimately altered the fatty acid profile, resulting in a 1.91-fold increase in DHA yield (8.81 g/L) and increased carbon flux by shifting it from carbohydrate and protein synthesis to lipid production. Thus, G6PD played a vital role in primary metabolism. In addition, G6PD significantly increased DHA content and lipid accumulation by 31.47% and 40.29%, respectively. The fed-batch fermentation experiment results showed that DHA production reached 17.01 g/L in the overexpressing G6PD strain. These results elucidated the beneficial effects of NADPH on the synthesis of PUFA in Schizochytrium sp. H016, which may be a potential target for metabolic engineering. Furthermore, this study provides a promising regulatory strategy for the large-scale production of DHA in Schizochytrium sp. Full article
(This article belongs to the Special Issue Commemorating the Launch of the Section “Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals”)
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18 pages, 7901 KiB  
Article
Purification and Identification of Peptides from Oyster (Crassostrea hongkongensis) Protein Enzymatic Hydrolysates and Their Anti-Skin Photoaging Effects on UVB-Irradiated HaCaT Cells
by Zhilan Peng, Jialong Gao, Weimin Su, Wenhong Cao, Guoping Zhu, Xiaoming Qin, Chaohua Zhang and Yi Qi
Mar. Drugs 2022, 20(12), 749; https://doi.org/10.3390/md20120749 - 28 Nov 2022
Cited by 7 | Viewed by 1856
Abstract
This study aimed to purify and identify antiphotoaging peptides from oyster (Crassostrea hongkongensis) protein enzymatic hydrolysates (OPEH) and to investigate the possible mechanism underlying its antiphotoaging effect. Multiple methods (Ultrafiltration, G25 Chromatography, RP-HPLC, and LC/MS/MS) had been used for this purpose, [...] Read more.
This study aimed to purify and identify antiphotoaging peptides from oyster (Crassostrea hongkongensis) protein enzymatic hydrolysates (OPEH) and to investigate the possible mechanism underlying its antiphotoaging effect. Multiple methods (Ultrafiltration, G25 Chromatography, RP-HPLC, and LC/MS/MS) had been used for this purpose, and eventually, two peptides, including WNLNP and RKNEVLGK, were identified. Particularly, WNLNP exerted remarkable antiphotoaging effect on the UVB-irradiated HaCaT photoaged cell model in a dose-dependent manner. WNLNP exerted its protective effect mainly through inhibiting ROS production, decreasing MMP-1 expression, but increasing extracellular pro-collagen I content. Furthermore, WNLNP downregulated p38, JNK, ERK, and p65 phosphorylation in the MAPK/NF-κB signaling pathway and attenuated bax over-expressions but reversed bcl-2 reduction in UVB- irradiated HaCaT cells. The molecular docking analysis showed that WNLNP forms five and seven hydrogen bonds with NF-κB (p65) and MMP-1, respectively. This study suggested that a pentapeptide WNLNP isolated from OPEH had great potential to prevent and regulate skin photoaging. Full article
(This article belongs to the Special Issue Commemorating the Launch of the Section “Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals”)
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17 pages, 2617 KiB  
Article
A Comparative Study of the Anti-Obesity Effects of Dietary Sea Cucumber Saponins and Energy Restriction in Response to Weight Loss and Weight Regain in Mice
by Lu Wen, Rong Li, Ying-Cai Zhao, Jin-Yue Yang, Xiao-Yue Li, Chang-Hu Xue, Tian-Tian Zhang and Yu-Ming Wang
Mar. Drugs 2022, 20(10), 629; https://doi.org/10.3390/md20100629 - 01 Oct 2022
Cited by 2 | Viewed by 2035
Abstract
Dietary supplementation of sea cucumber saponins and calorie restriction have been proved to be effective in alleviating obesity, but the differences of anti-obesity effects between sea cucumber saponins and energy restriction during weight loss and weight regain are still unknown. In the present [...] Read more.
Dietary supplementation of sea cucumber saponins and calorie restriction have been proved to be effective in alleviating obesity, but the differences of anti-obesity effects between sea cucumber saponins and energy restriction during weight loss and weight regain are still unknown. In the present study, high-fat-induced obesity mice were randomly divided into three groups, including a high-fat diet group (HF), an energy restriction by 40% group (HF-L), and a sea cucumber saponins group (HF-S), to compare the effects of dietary sea cucumber saponins and energy restriction on the weight, glucose, and lipid metabolism of obese mice during weight loss and weight regain. The results showed that dietary 0.06% sea cucumber saponins and limiting energy intake by 40% had the same weight loss effect. Interestingly, sea cucumber saponins could alleviate impaired glucose tolerance and insulin resistance caused by obesity. In addition, the inhibited SREBP-1c mediated lipogenesis might lead to the alleviation of weight regain after resuming the high-fat diet even when sea cucumber saponins were no longer supplemented. In contrast, limiting energy intake tended to promote lipid synthesis in the liver and white adipose tissue after restoring a high-fat diet, and inflammation was also induced. The findings indicated that sea cucumber saponins could replace calorie restriction to prevent obesity and might be used as a functional food or drug to resist obesity and related diseases caused by obesity. Full article
(This article belongs to the Special Issue Commemorating the Launch of the Section “Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals”)
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