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Special Issue "Bioactive Product from Marine Cyanobacteria"

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A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 10642

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Special Issue Editors

Prof. Dr. Martins Rosario

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Guest Editor

1. School of Health (ESS|P.PORTO), Polytechnic Institute of Porto, Porto, Portugal
2. Interdisciplinary Center of Marine and Environmental Research (CIIMAR), University of Porto, Porto, Portugal
Interests: cyanobacteria; pharmacology; toxicity; biotechnology
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Vitor Vasconcelos

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Guest Editor

1. Faculdade de Ciências da Universidade do Porto, 4169-007 Porto, Portugal
2. CIIMAR, Interdisciplinary Centre of Marine and Environmental Research of the University of Porto, 4450-208 Porto, Portugal
Interests: cyanobacteria; toxins; cyanotoxins; marine biotechnology; secondary metabolites; cyanobacterial blooms; ecotoxicology; environmental contamination
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cyanobacteria, as ancient photosynthetic prokaryotic organisms, produce a wide variety of secondary metabolites, including proteins, lipids, fatty acids, pigments or polysaccharides with proven biotechnological value, namely, in highly debilitating diseases such as cancer and obesogenic diseases, but also in processes such as photoprotection, antioxidation and inflammation. These secondary metabolites originating from cyanobacteria are widely employed in industries such as cosmetics, nutraceuticals, food, biomedicine, and green chemistry.

As the Guest Editors for this Special Issue, we would like to invite you to submit your valuable research results on “Bioactive Product from Marine Cyanobacteria”. This Special Issue invites original contributions and reviews.

Prof. Dr. Martins Rosario
Prof. Dr. Vitor Vasconcelos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

cyanobacteria
secondary metabolites
natural products
biological activity
synthesis

Published Papers (5 papers)

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Research

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Open AccessArticle

Metabolite Profile Characterization of Cyanobacterial Strains with Bioactivity on Lipid Metabolism Using In Vivo and In Vitro Approaches

Tiago Ribeiro

Kristín Jónsdóttir

Rene Hernandez-Bautista

Natália Gonçalves Silva

Begoña Sánchez-Astráin

Afshin Samadi

Finnur F. Eiriksson

Margrét Thorsteinsdóttir

Siegfried Ussar

and

Ralph Urbatzka

Mar. Drugs 2023, 21(9), 498; https://doi.org/10.3390/md21090498 - 19 Sep 2023

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Abstract

Cyanobacteria have demonstrated their therapeutic potential for many human diseases. In this work, cyanobacterial extracts were screened for lipid reducing activity in zebrafish larvae and in fatty-acid-overloaded human hepatocytes, as well as for glucose uptake in human hepatocytes and ucp1 mRNA induction in murine brown adipocytes. A total of 39 cyanobacteria strains were grown and their biomass fractionated, resulting in 117 chemical fractions. Reduction of neutral lipids in zebrafish larvae was observed for 12 fractions and in the human hepatocyte steatosis cell model for five fractions. The induction of ucp1 expression in murine brown adipocytes was observed in six fractions, resulting in a total of 23 bioactive non-toxic fractions. All extracts were analyzed by untargeted UPLC-Q-TOF-MS mass spectrometry followed by multivariate statistical analysis to prioritize bioactive strains. The metabolite profiling led to the identification of two markers with lipid reducing activity in zebrafish larvae. Putative compound identification using mass spectrometry databases identified them as phosphatidic acid and aromatic polyketides derivatives—two compound classes, which were previously associated with effects on metabolic disorders. In summary, we have identified cyanobacterial strains with promising lipid reducing activity, whose bioactive compounds needs to be identified in the future. Full article

(This article belongs to the Special Issue Bioactive Product from Marine Cyanobacteria)

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Open AccessArticle

Barbamide Displays Affinity for Membrane-Bound Receptors and Impacts Store-Operated Calcium Entry in Mouse Sensory Neurons

and

Mar. Drugs 2023, 21(2), 110; https://doi.org/10.3390/md21020110 - 02 Feb 2023

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Abstract

Marine cyanobacteria are a rich source of bio-active metabolites that have been utilized as leads for drug discovery and pharmacological tools for basic science research. Here, we describe the re-isolation of a well-known metabolite, barbamide, from Curaçao on three different occasions and the characterization of barbamide’s biological interactions with targets of the mammalian nervous system. Barbamide was originally discovered as a molluscicidal agent from a filamentous marine cyanobacterium. In our hands, we found little evidence of toxicity against mammalian cell cultures. However, barbamide showed several affinities when screened for binding affinity for a panel of 45 receptors and transporters known to be involved in nociception and sensory neuron activity. We found high levels of binding affinity for the dopamine transporter, the kappa opioid receptor, and the sigma receptors (sigma-1 and sigma-2 also known as transmembrane protein 97; TMEM97). We tested barbamide in vitro in isolated sensory neurons from female mice to explore its functional impact on calcium flux in these cells. Barbamide by itself had no observable impact on calcium flux. However, barbamide enhanced the effect of the TRPV1 agonist capsaicin and enhanced store-operated calcium entry (SOCE) responses after depletion of intracellular calcium. Overall, these results demonstrate the biological potential of barbamide at sensory neurons with implications for future drug development projects surrounding this molecule. Full article

(This article belongs to the Special Issue Bioactive Product from Marine Cyanobacteria)

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Open AccessArticle

Cosmetic Application of Cyanobacteria Extracts with a Sustainable Vision to Skincare: Role in the Antioxidant and Antiaging Process

and

Mar. Drugs 2022, 20(12), 761; https://doi.org/10.3390/md20120761 - 02 Dec 2022

Cited by 2 | Viewed by 1992

Abstract

Nature-based and sustainably sourced cosmetics have been dominating the area of skincare products worldwide. Due to their antioxidant and antiaging properties, compounds from cyanobacteria, such as carotenoids and phycobiliproteins, may replace synthetic ingredients in cosmetic formulations and may be used in products such as sunscreens, skincare creams, and makeup. In this study, we evaluated the potential of acetonic and aqueous extracts from cyanobacteria strains of the genera Cyanobium and Leptothoe and from strains within Synechococcales and Oscillatoriales orders, for use in cosmetics. Extractions were sequentially performed with acetone and water. Extracts were firstly analyzed for their toxicity to keratinocytes, fibroblasts, and endothelial cells (HaCAT, 3T3L1 and hCMEC/D3, respectively). The non-cytotoxic extracts were characterized in terms of total proteins, carotenoids, chlorophyll, phenols, phycobiliproteins, and analyzed for their antioxidant potential against the superoxide anion radical (O₂^•−), and for their ability to inhibit key enzymes associated with the skin aging process. Aqueous extracts were richer in total proteins and phycobiliproteins. The aqueous extracts of Synechococcales cyanobacterium LEGE 181157 and Synechococcales cyanobacterium LEGE 181150 showed the highest value for total proteins (760.81 and 695.25 μg BSA mL⁻¹_{dry extract,} respectively) and the best values regarding O₂^•− scavenging (IC₅₀ = 63.24 and 112.18 μg mL⁻¹_{dry extract}, respectively) with a significant negative correlation observed (p < 0.01). Moreover, aqueous extracts of Synechococcales cyanobacterium LEGE 181150 and Synechococcales cyanobacterium LEGE 181157 inhibited hyaluronidase, (IC₅₀ of 483.86 and 645.06 μg mL⁻¹_{dry extract}, respectively), with a significant negative correlation with total proteins (p < 0.05), pointing out the contribution of these compounds to the biological activities observed. Acetonic extracts were richer in carotenoids and phenols. Zeaxanthin and β-carotene were predominant among all strains, being present in higher amount in Cyanobium sp. LEGE 07175 (53.08 μg mg⁻¹) and Leptothoe sp. LEGE 181156 (47.89 μg mg⁻¹), respectively. The same strains also showed the highest values for collagenase inhibition at 750 μg mL⁻¹_{dry extract} (32.88 and 36.61%, respectively). Furthermore, Leptothoe sp. LEGE 181156 exhibited the lowest IC₅₀ value for tyrosinase inhibition (465.92 μg mL⁻¹_{dry extract}) and Synechococcales cyanobacterium LEGE 181157 presented the best values for elastase inhibition (IC₅₀ of 380.50 and IC₂₅ of 51.43 μg mL⁻¹_{dry extract}). In general, cyanobacteria extracts demonstrated potential for being used for antiaging purposes, with aqueous extracts being more efficient at free radicals scavenging and acetonic ones at avoiding degradation of dermal matrix components. Full article

(This article belongs to the Special Issue Bioactive Product from Marine Cyanobacteria)

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Review

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Review of Marine Cyanobacteria and the Aspects Related to Their Roles: Chemical, Biological Properties, Nitrogen Fixation and Climate Change

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Mar. Drugs 2023, 21(8), 439; https://doi.org/10.3390/md21080439 - 03 Aug 2023

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Abstract

Marine cyanobacteria are an ancient group of photosynthetic microbes dating back to 3.5 million years ago. They are prolific producers of bioactive secondary metabolites. Over millions of years, natural selection has optimized their metabolites to possess activities impacting various biological targets. This paper discusses the historical and existential records of cyanobacteria, and their role in understanding the evolution of marine cyanobacteria through the ages. Recent advancements have focused on isolating and screening bioactive compounds and their respective medicinal properties, and we also discuss chemical property space and clinical trials, where compounds with potential pharmacological effects, such as cytotoxicity, anticancer, and antiparasitic properties, are highlighted. The data have shown that about 43% of the compounds investigated have cytotoxic effects, and around 8% have anti-trypanosome activity. We discussed the role of different marine cyanobacteria groups in fixing nitrogen percentages on Earth and their outcomes in fish productivity by entering food webs and enhancing productivity in different agricultural and ecological fields. The role of marine cyanobacteria in the carbon cycle and their outcomes in improving the efficiency of photosynthetic CO₂ fixation in the chloroplasts of crop plants, thus enhancing the crop plant’s yield, was highlighted. Ultimately, climate changes have a significant impact on marine cyanobacteria where the temperature rises, and CO₂ improves the cyanobacterial nitrogen fixation. Full article

(This article belongs to the Special Issue Bioactive Product from Marine Cyanobacteria)

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Open AccessReview

Cyanobacteria: A Promising Source of Antifungal Metabolites

Samuel Cavalcante do Amaral

Luciana Pereira Xavier

Vítor Vasconcelos

and

Agenor Valadares Santos

Mar. Drugs 2023, 21(6), 359; https://doi.org/10.3390/md21060359 - 14 Jun 2023

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Abstract

Cyanobacteria are a rich source of secondary metabolites, and they have received a great deal of attention due to their applicability in different industrial sectors. Some of these substances are known for their notorious ability to inhibit fungal growth. Such metabolites are very chemically and biologically diverse. They can belong to different chemical classes, including peptides, fatty acids, alkaloids, polyketides, and macrolides. Moreover, they can also target different cell components. Filamentous cyanobacteria have been the main source of these compounds. This review aims to identify the key features of these antifungal agents, as well as the sources from which they are obtained, their major targets, and the environmental factors involved when they are being produced. For the preparation of this work, a total of 642 documents dating from 1980 to 2022 were consulted, including patents, original research, review articles, and theses. Full article

(This article belongs to the Special Issue Bioactive Product from Marine Cyanobacteria)

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