Submit to Special Issue Submit Abstract to Special Issue Review for Marine Drugs Propose a Special Issue

Journal Menu

Journal Browser

► Journal Browser

Special Issue "Collagen and Bioactives from Marine By-Products"

Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 December 2023 | Viewed by 7047

Share This Special Issue

Special Issue Editors

Dr. Michela Sugni

E-Mail Website
Guest Editor

Department of Environmental Science and Policy, University of Milan, Via Celoria, 2, 20133 Milan, Italy
Interests: marine collagen; biomaterials; echinoderms; regeneration; circular economy

Dr. Stefania Marzorati

E-Mail Website
Guest Editor

Department of Environmental Science and Policy, University of Milan, Via Celoria, 2, 20133 Milan, Italy
Interests: bioactive compounds from agro-industrial and food wastes; supercritical CO₂ extraction; green technologies; green chemistry; pigments; antioxidants; materials chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, there has been growing interest in the main societal challenges of waste recycling and valorization, two of the pillars of the Circular Economy approach. According to the latter, waste materials and byproducts are used as “secondary resources” for the development of new products, while reducing their socioeconomic and environmental impacts. In this context, byproducts from marine resources (mainly, but not only, from the food industry) are becoming a promising and abundant source of compounds to be reused for different human applications. These natural products include a large spectrum of both structural and bioactive molecules. Among the former, marine collagens are a rapidly expanding field of research.

The focus of this Special Issue will be to provide an overview of the latest research addressed to the valorization of marine byproducts toward different applied fields, gathering and publishing original articles and review papers on (but not limited to) the following topics:

Waste valorization strategies applied to marine-derived products;
Marine biomaterials and bioactive extraction strategies;
Biocomposite and biomaterial design and characterization;
Bioprinting and materials design;
Applications in anticancer therapies, antimicrobial, anti-inflammatory treatments.

Both basic (e.g., novel extraction strategies, chemical/biological/functional characterization of the molecule) and applied research (e.g., in vivo efficacy testing) are welcome.

Dr. Michela Sugni
Dr. Stefania Marzorati
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

marine collagen
biomaterials
circular economy
byproducts
antioxidants
bioactives
polyphenols
anti-inflammatory activity
antitumoral activity
added-value compounds
composite materials
skin regeneration

Published Papers (5 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Jump to: Review

Open AccessArticle

Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from the Collagens of Monkfish (Lophius litulon) Swim Bladders: Isolation, Characterization, Molecular Docking Analysis and Activity Evaluation

and

Mar. Drugs 2023, 21(10), 516; https://doi.org/10.3390/md21100516 (registering DOI) - 28 Sep 2023

Abstract

The objective of this study was to isolate and characterize collagen and angiotensin-I-converting enzyme (ACE)-inhibitory (ACEi) peptides from the swim bladders of monkfish (Lophius litulon). Therefore, acid-soluble collagen (ASC-M) and pepsin-soluble collagen (PSC-M) with yields of 4.27 ± 0.22% and 9.54 ± 0.51%, respectively, were extracted from monkfish swim bladders using acid and enzyme methods. The ASC-M and PSC-M contained Gly (325.2 and 314.9 residues/1000 residues, respectively) as the major amino acid, but they had low imino acid content (192.5 and 188.6 residues/1000 residues, respectively) in comparison with collagen from calf skins (CSC) (216.6 residues/1000 residues). The sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) patterns and ultraviolet (UV) absorption spectrums of ASC-M and PSC-M illustrated that they were mainly composed of type I collagen. Subsequently, three ACEi peptides were isolated from a PSC-M hydrolysate prepared via a double-enzyme system (alcalase + neutrase) and identified as SEGPK (MHP6), FDGPY (MHP7) and SPGPW (MHP9), with molecular weights of 516.5, 597.6 and 542.6 Da, respectively. SEGPK, FDGPY and SPGPW displayed remarkable anti-ACE activity, with IC₅₀ values of 0.63, 0.94 and 0.71 mg/mL, respectively. Additionally, a molecular docking assay demonstrated that the affinities of SEGPK, FDGPY and SPGPW with ACE were −7.3, −10.9 and −9.4 kcal/mol, respectively. The remarkable ACEi activity of SEGPK, FDGPY and SPGPW was due to their connection with the active pockets and/or sites of ACE via hydrogen bonding, hydrophobic interaction and electrostatic force. Moreover, SEGPK, FDGPY and SPGPW could protect HUVECs by controlling levels of nitric oxide (NO) and endothelin-1 (ET-1). Therefore, this work provides an effective means for the preparation of collagens and novel ACEi peptides from monkfish swim bladders, and the prepared ACEi peptides, including SEGPK, FDGPY and SPGPW, could serve as natural functional components in the development of health care products to control hypertension. Full article

(This article belongs to the Special Issue Collagen and Bioactives from Marine By-Products)

► Show Figures

Graphical abstract

Open AccessArticle

Swim Bladder of Farmed Totoaba macdonaldi: A Source of Value-Added Collagen

Honorio Cruz-López

Sergio Rodríguez-Morales

Luis M. Enríquez-Paredes

Luis Jesús Villarreal-Gómez

Conal True

Leticia Olivera-Castillo

D. Alejandro Fernández-Velasco

and

Lus M. López

Mar. Drugs 2023, 21(3), 173; https://doi.org/10.3390/md21030173 - 09 Mar 2023

Viewed by 1117

Abstract

Finding strategies to use the swim bladder of farmed totoaba (Totoaba macdonaldi) is of the utmost need to reduce waste. Fish swim bladders are rich in collagen; hence, extracting collagen is a promising alternative with benefits for aquaculture of totoaba and the environment. The elemental biochemical composition of totoaba swim bladders, including their proximate and amino acid compositions, was determined. Pepsin-soluble collagen (PSC) was used to extract collagen from swim bladders, and its characteristics were analyzed. Alcalase and papain were used for the preparation of collagen hydrolysates. Swim bladders contained 95% protein, 2.4% fat, and 0.8% ash (on a dry basis). The essential amino acid content was low, but the functional amino acid content was high. The PSC yield was high, at 68% (dry weight). The amino acid composition profile, electrophoretic pattern, and structural integrity analyses of the isolated collagen suggested it is a typical type-I collagen with high purity. The denaturalization temperature was 32.5 °C, probably attributable to the imino acid content (205 residues/1000 residues). Papain-hydrolysates (≤3 kDa) of this collagen exhibited higher radical scavenging activity than Alcalase-hydrolysates. The swim bladder from the farmed totoaba could be an ideal source to produce high-quality type I collagen and may be considered an alternative to conventional collagen sources or bioactive peptides. Full article

(This article belongs to the Special Issue Collagen and Bioactives from Marine By-Products)

► Show Figures

Figure 1

Open AccessArticle

An In Vivo Study to Evaluate the Efficacy of Blue Shark (Prionace glauca) Cartilage Collagen as a Cosmetic

Amanda Tresiliana Mulio

and

Po-Hsien Li

Mar. Drugs 2022, 20(10), 633; https://doi.org/10.3390/md20100633 - 05 Oct 2022

Cited by 2 | Viewed by 1759

Abstract

The “blue shark”, Prionace glauca (class: Chondrichthyes), is a pelagic shark species commonly found in tropical and temperate oceans. This shark is mainly sold in Asian countries as food and as traditional Chinese medicine. According to the Red List of the International Union for the Conservation of Nature, P. glauca is classified as low-risk to near endangered. P. glauca cartilage contains collagen type II, which makes it suitable as a bioactive ingredient in cosmeceutical products. This study evaluated the effects of a gel containing various concentrations (0.125–5%) of lyophilized hydrolyzed P. glauca cartilage on the human inner wrist skin compared to a placebo (base). A skin properties evaluation test was conducted before and after applying various concentrations (0.125–5%) of the P. glauca cartilage gel for 10 and 20 min on the inner wrists of participants using a skin analyzer that determined the moisture level, oil level, texture level, complexion level, and the 3D level. Adding lyophilized hydrolyzed shark cartilage (LHSC) significantly improved the moisture, texture, and complexion of the skin while controlling oil and providing a wrinkle-smoothing effect. The result indicated that LHSC formulations were prepared at different concentrations, and they had significantly enhanced effects on skin hydration and elasticity (texture) and the smoothing of wrinkles (3D level). The LHSC also effectively controlled oil secretion and the complexion. Full article

(This article belongs to the Special Issue Collagen and Bioactives from Marine By-Products)

► Show Figures

Figure 1

Open AccessArticle

Physicochemical, Structural and Antioxidant Properties of Collagens from the Swim Bladder of Four Fish Species

Ye Dong

and

Zhiyuan Dai

Mar. Drugs 2022, 20(9), 550; https://doi.org/10.3390/md20090550 - 26 Aug 2022

Cited by 5 | Viewed by 1312

Abstract

This study aimed to isolate and characterize pepsin-solubilized collagen (PSC) from marine and freshwater fish swim bladders. The physicochemical properties, protein pattern, amino acid composition, structure, thermal denaturation temperature, and antioxidant activity of PSC from four different swim bladder sources were investigated and compared. The results demonstrated that the four types of collagen extracted were all type I collagen. The yield of PSC extracted from grass carp (GCSB-PSC), bighead carp (BCSB-PSC), grouper (GSB-PSC), and monkfish swim bladders (MSB-PSC) were 38.98, 27.97, 18.16, and 10.35%, respectively. Compared to the other three PSCs, BCSB-PSC has the highest thermal denaturation temperature (38.60 °C). Based on FTIR spectroscopy and circular dichroism (CD) analysis, the extracted PSCs retained the triple helix and secondary structure well. Antioxidant studies showed that in the swim bladders of four species the swim bladder PSC could scavenge DPPH and ABTS radicals. Overall, swim bladders from marine and freshwater fish can be utilized as raw materials for collagen extraction, and the extracted collagen has potential commercial applications. Full article

(This article belongs to the Special Issue Collagen and Bioactives from Marine By-Products)

► Show Figures

Figure 1

Review

Jump to: Research

Open AccessReview

A Review of the Chemical Extraction of Chitosan from Shrimp Wastes and Prediction of Factors Affecting Chitosan Yield by Using an Artificial Neural Network

Ahmed Hosney

Sana Ullah

and

Karolina Barčauskaitė

Mar. Drugs 2022, 20(11), 675; https://doi.org/10.3390/md20110675 - 28 Oct 2022

Cited by 8 | Viewed by 2297

Abstract

There are two viable options to produce shrimp shells as by-product waste, either within the shrimp production phases or when the shrimp are peeled before cooking by the end user. This waste is considered a double-edged sword, as it is possible to be either a source of environmental pollution, through dumping and burning, or a promising source from which to produce chitosan as a biodegradable, biocompatible biopolymer which has a variety of agricultural, industrial, and biomedical applications. Chitosan is a deacetylated form of chitin that can be chemically recovered from shrimp shells through the three sequential stages of demineralization, deproteinization, and deacetylation. The main aim of this review paper is to summarize the recent literature on the chemical extraction of chitosan from shrimp shells and to represent the physicochemical properties of chitosan extracted from shrimp shells in different articles, such as chitosan yield, moisture content, solubility, ash content, and degree of deacetylation. Another aim is to analyze the influence of the main predictors of the chemical extraction stages (demineralization, deproteinization, and deacetylation) on the chitosan yield percentage by using a multilayer perceptron artificial neural network. This study showed that the deacetylation alkali concentration is the most crucial parameter, followed by the concentrations of acid and alkali of demineralization and deproteinization, respectively. The current review was conducted to be used in prospective studies for optimizing the chemical extraction of chitosan from shrimp wastes. Full article

(This article belongs to the Special Issue Collagen and Bioactives from Marine By-Products)

► Show Figures

Journal Menu

Journal Browser

Special Issue "Collagen and Bioactives from Marine By-Products"

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Published Papers (5 papers)

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI