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Marine Drugs
Special Issues
Exploring of Microalgae for Biotechnology Applications
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Special Issue "Exploring of Microalgae for Biotechnology Applications"

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 1042

Special Issue Editor

Dr. Xuemei Mao
E-Mail Website
Guest Editor
Department of Civil Engineering, The University of Hong Kong, Hong Kong, China
Interests: microalgal biotechnology; metabolic engineering; natural products; metagenomics

Special Issue Information

Dear Colleagues,

Microalgae are widely used in various biotechnological industries including food, nutraceutical, biomedical, agriculture, and environmental processes. To promote the application of microalgae in these areas, better knowledge of their characteristics, and technological advancements in cultivation and downstream processing, are needed. Furthermore, new possibilities for biotechnological applications should be explored. This Special Issue is seeking high-quality research articles and reviews to discuss recent achievements in the biotechnology applications of microalgae for bioactive compound and bio-product production, or their other potentials in pharmaceutical, nutraceutical, or biomedical industries. As the Guest Editor, it's my pleasure to invite researchers in this field to contribute their latest research advances to this Special Issue.

Dr. Xuemei Mao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microalgae
  • biotechnology
  • bioactive natural products
  • microalgal cultivation
  • nutraceutical
  • biomedical
  • industrial application

Published Papers (1 paper)

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Research

12 pages, 2153 KiB  
Article
Alkaline Phosphatase PhoD Mutation Induces Fatty Acid and Long-Chain Polyunsaturated Fatty Acid (LC-PUFA)-Bound Phospholipid Production in the Model Diatom Phaeodactylum tricornutum
by
Kaidian Zhang
,
Jiashun Li
,
Jie Cheng
and
Senjie Lin
Mar. Drugs 2023, 21(11), 560; https://doi.org/10.3390/md21110560 - 26 Oct 2023
Viewed by 916
Abstract
With rapid growth and high lipid contents, microalgae have become promising environmentally friendly candidates for renewable biodiesel and health supplements in our era of global warming and energy depletion. Various pathways have been explored to enhance algal lipid production, especially gene editing. Previously, [...] Read more.
With rapid growth and high lipid contents, microalgae have become promising environmentally friendly candidates for renewable biodiesel and health supplements in our era of global warming and energy depletion. Various pathways have been explored to enhance algal lipid production, especially gene editing. Previously, we found that the functional loss of PhoD-type alkaline phosphatase (AP), a phosphorus-stress indicator in phytoplankton, could lead to increased lipid contents in the model diatom Phaeodactylum tricornutum, but how the AP mutation may change lipid composition remains unexplored. This study addresses the gap in the research and investigates the effects of PhoD-type AP mutation on the lipid composition and metabolic regulation in P. tricornutum using transcriptomic and lipidomic analyses. We observed significantly modified lipid composition and elevated production of fatty acids, lysophosphatidylcholine, lysophosphatidylethanolamine, ceramide, phosphatidylinositol bisphosphate, and monogalactosylmonoacylglycerol after PhoD_45757 mutation. Meanwhile, genes involved in fatty acid biosynthesis were upregulated in mutant cells. Moreover, the mutant exhibited increased contents of ω-3 long-chain polyunsaturated fatty acid (LC-PUFA)-bound phospholipids, indicating that PhoD_45757 mutation could improve the potential bioavailability of PUFAs. Our findings indicate that AP mutation could influence cellular lipid synthesis and probably redirect carbon toward lipid production and further demonstrate that AP mutation is a promising approach for the development of high-value microalgal strains for biomedical and other applications. Full article
(This article belongs to the Special Issue Exploring of Microalgae for Biotechnology Applications)
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