Bio-Active Components from Marine Sponges

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 5542

Special Issue Editors


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Guest Editor
IRD, CNRS, Ifremer, University Brest, LEMAR, F-29280 Plouzane, France
Interests: marine invertebrates; natural product extraction; natural product isolation; bioactive compounds; chemotaxonomy; quorum sensing; anticancer and anti-infective agents; scientific database
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Guest Editor
CNRS, Institut de Chimie des Substances Naturelles, Université Paris-Saclay, F-91190 Gif-sur-Yvette, France
Interests: bioactive substances from marine organisms; natural product isolation; biomechanistic analysis; biomimetic synthesis; total synthesis; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,                

This Special Issue focuses on bioactive components derived from marine sponges, and offers researchers the opportunity to publish original work on various topics, including: natural products derived from sponges and their associated micro-organisms; the presentation of biological activities in many domains, whether for health-related, environmental, or biotechnological applications; and chemical ecology studies. Sustainable production via chemical synthesis and bioproduction through the culture of these bioactive specialized marine metabolites are of a great interest in the context of blue chemistry. In this Special Issue, we welcome papers on all of these chemical, biological, and ecological aspects.

Dr. Sylvain Petek
Dr. Ali Al-Mourabit
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sponges
  • isolation
  • synthesis
  • bioactivity
  • anti-cancer
  • anti-infective
  • human health
  • animal health
  • eco-friendly solution
  • chemical ecology

Published Papers (5 papers)

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Research

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15 pages, 4979 KiB  
Article
Methanolic Extract and Brominated Compound from the Brazilian Marine Sponge Aplysina fulva Are Neuroprotective and Modulate Inflammatory Profile of Microglia
by Catarina de Jesus Nunes, Cinthia Cristina Santos, Erica Novaes Soares, Irlã Santos Lima, Uesley Vieira Alves, Emílio Lanna, Ronan Batista, Ravena Pereira do Nascimento and Silvia Lima Costa
Mar. Drugs 2024, 22(6), 235; https://doi.org/10.3390/md22060235 - 22 May 2024
Viewed by 187
Abstract
Neurodegenerative diseases involve neuroinflammation and a loss of neurons, leading to disability and death. Hence, the research into new therapies has been focused on the modulation of the inflammatory response mainly by microglia/macrophages. The extracts and metabolites of marine sponges have been presented [...] Read more.
Neurodegenerative diseases involve neuroinflammation and a loss of neurons, leading to disability and death. Hence, the research into new therapies has been focused on the modulation of the inflammatory response mainly by microglia/macrophages. The extracts and metabolites of marine sponges have been presented as anti-inflammatory. This study evaluated the toxicity of an extract and purified compound from the Brazilian marine sponge Aplysina fulva as well as its neuroprotection against inflammatory damage associated with the modulation of microglia response. PC12 neuronal cells and neonatal rat microglia were treated with the methanolic extract of A. fulva (AF-MeOH, 0.1–200 μg/mL) or with its purified dimethyl ketal of 3,5-dibromoverongiaquinol (AF-H1, 0.1–100 μM). Cytotoxicity was determined by MTT tetrazolium, Trypan blue, and propidium iodide; microglia were also treated with the conditioned medium (CM) from PC12 cells in different conditions. The microglia phenotype was determined by the expression of Iba-1 and CD68. AF-MeOH and AF-H1 were not toxic to PC12 or the microglia. Inflammatory damage with Escherichia coli lipopolysaccharide (LPS, 5 μg/mL) was not observed in the PC12 cells treated with AF-MeOH (1–10 μg/mL) or AF-H1 (1–10 μM). Microglia subjected to the CM from PC12 cells treated with LPS and AF-MeOH or AF-H1 showed the control phenotype-like (multipolar, low-CD68), highlighting the anti-neuroinflammatory and neuroprotective effect of components of this marine sponge. Full article
(This article belongs to the Special Issue Bio-Active Components from Marine Sponges)
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12 pages, 637 KiB  
Article
Denigrins H–L: Sulfated Derivatives of Denigrins D and E from a New Zealand Dictyodendrilla c.f. dendyi Marine Sponge
by Lauren Gris, Michèle R. Prinsep, Linda M. Peters and Christopher N. Battershill
Mar. Drugs 2024, 22(5), 231; https://doi.org/10.3390/md22050231 - 20 May 2024
Viewed by 325
Abstract
Five new sulfated arylpyrrole and arylpyrrolone alkaloids, denigrins H–L (15), along with two known compounds, dictyodendrin B and denigrin G, were isolated from an extract of a New Zealand Dictyodendrilla c.f. dendyi marine sponge. Denigrins H–L represent the first [...] Read more.
Five new sulfated arylpyrrole and arylpyrrolone alkaloids, denigrins H–L (15), along with two known compounds, dictyodendrin B and denigrin G, were isolated from an extract of a New Zealand Dictyodendrilla c.f. dendyi marine sponge. Denigrins H–L represent the first examples of sulfated denigrins, with denigrins H and I (12), as derivatives of denigrin D, containing a pyrrolone core, and denigrins J–L (35), as derivatives of denigrin E (6), containing a pyrrole core. Their structures were elucidated by interpretation of 1D and 2D NMR spectroscopic data, ESI, and HR-ESI-MS spectrometric data, as well as comparison with literature data. Compounds 1–5, along with six known compounds previously isolated from the same extract, showed minimal cytotoxicity against the HeLa cervical cancer cell line. Full article
(This article belongs to the Special Issue Bio-Active Components from Marine Sponges)
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20 pages, 2736 KiB  
Article
Chemical Investigation of the Calcareous Marine Sponge Pericharax heteroraphis, Clathridine-A Related Derivatives Isolation, Synthesis and Osteogenic Activity
by Capucine Jourdain de Muizon, Céline Moriou, Marceau Levasseur, David Touboul, Bogdan I. Iorga, Hristo Nedev, Elsa Van Elslande, Pascal Retailleau, Sylvain Petek, Eric Folcher, Arnaud Bianchi, Mireille Thomas, Solène Viallon, Sylvie Peyroche, Sarah Nahle, Marthe Rousseau and Ali Al-Mourabit
Mar. Drugs 2024, 22(5), 196; https://doi.org/10.3390/md22050196 - 25 Apr 2024
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Abstract
As a result of screening a panel of marine organisms to identify lead molecules for the stimulation of endochondral bone formation, the calcareous sponge Pericharax heteroraphis was identified to exhibit significant activity during endochondral differentiation. On further molecular networking analysis, dereplication and chemical [...] Read more.
As a result of screening a panel of marine organisms to identify lead molecules for the stimulation of endochondral bone formation, the calcareous sponge Pericharax heteroraphis was identified to exhibit significant activity during endochondral differentiation. On further molecular networking analysis, dereplication and chemical fractionation yielded the known clathridine A-related metabolites 3–6 and the homodimeric complex (clathridine A)2 Zn2+ (9), together with the new unstable heterodimeric complex (clathridine A–clathridimine)Zn2+ (10). With the presence of the zinc complexes annotated through the LC-MS analysis of the crude extract changing due to the instability of some metabolites and complexes constituting the mixture, we combined the isolation of the predicted molecules with their synthesis in order to confirm their structure and to understand their reactivity. Interestingly, we also found a large quantity of the contaminant benzotriazoles BTZ (7) and its semi-dimer (BTZ)2CH2 (8), which are known to form complexes with transition metals and are used for preventing corrosion in water. All isolated 2-aminoimidazole derivatives and complexes were synthesized not only for structural confirmation and chemical understanding but to further study their bioactivity during endochondral differentiation, particularly the positively screened imidazolone derivatives. Compounds leucettamine B, clathridine A and clathridimine were found to increase type X collagen transcription and stimulate endochondral ossification in the ATDC5 micromass model. Full article
(This article belongs to the Special Issue Bio-Active Components from Marine Sponges)
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Review

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23 pages, 3410 KiB  
Review
Spongia Sponges: Unabated Sources of Novel Secondary Metabolites
by Qi-Bin Yang and Lin-Fu Liang
Mar. Drugs 2024, 22(5), 213; https://doi.org/10.3390/md22050213 - 7 May 2024
Viewed by 473
Abstract
Marine sponges of the genus Spongia have proven to be unabated sources of novel secondary metabolites with remarkable scaffold diversities and significant bioactivities. The discovery of chemical substances from Spongia sponges has continued to increase over the last few years. The current work [...] Read more.
Marine sponges of the genus Spongia have proven to be unabated sources of novel secondary metabolites with remarkable scaffold diversities and significant bioactivities. The discovery of chemical substances from Spongia sponges has continued to increase over the last few years. The current work provides an up-to-date literature survey and comprehensive insight into the reported metabolites from the members of the genus Spongia, as well as their structural features, biological activities, and structure–activity relationships when available. In this review, 222 metabolites are discussed based on published data from the period from mid-2015 to the beginning of 2024. The compounds are categorized into sesquiterpenes, diterpenes, sesterterpenes, meroterpenes, linear furanoterpenes, steroids, alkaloids, and other miscellaneous substances. The biological effects of these chemical compositions on a vast array of pharmacological assays including cytotoxic, anti-inflammatory, antibacterial, neuroprotective, protein tyrosine phosphatase 1B (PTP1B)-inhibitory, and phytoregulating activities are also presented. Full article
(This article belongs to the Special Issue Bio-Active Components from Marine Sponges)
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47 pages, 10791 KiB  
Review
Genus Acanthella—A Wealthy Treasure: Secondary Metabolites, Synthesis, Biosynthesis, and Bioactivities
by Sabrin R. M. Ibrahim, Kholoud F. Ghazawi, Samar F. Miski, Duaa Fahad ALsiyud, Shaimaa G. A. Mohamed and Gamal A. Mohamed
Mar. Drugs 2023, 21(4), 257; https://doi.org/10.3390/md21040257 - 21 Apr 2023
Viewed by 3370
Abstract
Marine sponges are multicellular and primitive animals that potentially represent a wealthy source of novel drugs. The genus Acanthella (family Axinellidae) is renowned to produce various metabolites with various structural characteristics and bioactivities, including nitrogen-containing terpenoids, alkaloids, and sterols. The current work provides [...] Read more.
Marine sponges are multicellular and primitive animals that potentially represent a wealthy source of novel drugs. The genus Acanthella (family Axinellidae) is renowned to produce various metabolites with various structural characteristics and bioactivities, including nitrogen-containing terpenoids, alkaloids, and sterols. The current work provides an up-to-date literature survey and comprehensive insight into the reported metabolites from the members of this genus, as well as their sources, biosynthesis, syntheses, and biological activities whenever available. In the current work, 226 metabolites have been discussed based on published data from the period from 1974 to the beginning of 2023 with 90 references. Full article
(This article belongs to the Special Issue Bio-Active Components from Marine Sponges)
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