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Journals
Marine Drugs
Special Issues
Bio-Active Components from Marine Sponges
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Bio-Active Components from Marine Sponges

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 3737

Special Issue Editors

Dr. Sylvain Petek

E-Mail Website
Guest Editor
IRD, CNRS, Ifremer, University Brest, LEMAR, F-29280 Plouzane, France
Interests: marine invertebrates; natural product extraction; natural product isolation; bioactive compounds; chemotaxonomy; quorum sensing; anticancer and anti-infective agents; scientific database
Special Issues, Collections and Topics in MDPI journals
Dr. Ali Al-Mourabit

E-Mail Website
Guest Editor
CNRS, Institut de Chimie des Substances Naturelles, Université Paris-Saclay, F-91190 Gif-sur-Yvette, France
Interests: bioactive substances from marine organisms; natural product isolation; biomechanistic analysis; biomimetic synthesis; total synthesis; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,                

This Special Issue focuses on bioactive components derived from marine sponges, and offers researchers the opportunity to publish original work on various topics, including: natural products derived from sponges and their associated micro-organisms; the presentation of biological activities in many domains, whether for health-related, environmental, or biotechnological applications; and chemical ecology studies. Sustainable production via chemical synthesis and bioproduction through the culture of these bioactive specialized marine metabolites are of a great interest in the context of blue chemistry. In this Special Issue, we welcome papers on all of these chemical, biological, and ecological aspects.

Dr. Sylvain Petek
Dr. Ali Al-Mourabit
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sponges
  • isolation
  • synthesis
  • bioactivity
  • anti-cancer
  • anti-infective
  • human health
  • animal health
  • eco-friendly solution
  • chemical ecology

Published Papers (2 papers)

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Research

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20 pages, 2736 KiB  
Article
Chemical Investigation of the Calcareous Marine Sponge Pericharax heteroraphis, Clathridine-A Related Derivatives Isolation, Synthesis and Osteogenic Activity
by Capucine Jourdain de Muizon, Céline Moriou, Marceau Levasseur, David Touboul, Bogdan I. Iorga, Hristo Nedev, Elsa Van Elslande, Pascal Retailleau, Sylvain Petek, Eric Folcher, Arnaud Bianchi, Mireille Thomas, Solène Viallon, Sylvie Peyroche, Sarah Nahle, Marthe Rousseau and Ali Al-Mourabit
Mar. Drugs 2024, 22(5), 196; https://doi.org/10.3390/md22050196 - 25 Apr 2024
Abstract
As a result of screening a panel of marine organisms to identify lead molecules for the stimulation of endochondral bone formation, the calcareous sponge Pericharax heteroraphis was identified to exhibit significant activity during endochondral differentiation. On further molecular networking analysis, dereplication and chemical [...] Read more.
As a result of screening a panel of marine organisms to identify lead molecules for the stimulation of endochondral bone formation, the calcareous sponge Pericharax heteroraphis was identified to exhibit significant activity during endochondral differentiation. On further molecular networking analysis, dereplication and chemical fractionation yielded the known clathridine A-related metabolites 3–6 and the homodimeric complex (clathridine A)2 Zn2+ (9), together with the new unstable heterodimeric complex (clathridine A–clathridimine)Zn2+ (10). With the presence of the zinc complexes annotated through the LC-MS analysis of the crude extract changing due to the instability of some metabolites and complexes constituting the mixture, we combined the isolation of the predicted molecules with their synthesis in order to confirm their structure and to understand their reactivity. Interestingly, we also found a large quantity of the contaminant benzotriazoles BTZ (7) and its semi-dimer (BTZ)2CH2 (8), which are known to form complexes with transition metals and are used for preventing corrosion in water. All isolated 2-aminoimidazole derivatives and complexes were synthesized not only for structural confirmation and chemical understanding but to further study their bioactivity during endochondral differentiation, particularly the positively screened imidazolone derivatives. Compounds leucettamine B, clathridine A and clathridimine were found to increase type X collagen transcription and stimulate endochondral ossification in the ATDC5 micromass model. Full article
(This article belongs to the Special Issue Bio-Active Components from Marine Sponges)
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Review

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47 pages, 10791 KiB  
Review
Genus Acanthella—A Wealthy Treasure: Secondary Metabolites, Synthesis, Biosynthesis, and Bioactivities
by Sabrin R. M. Ibrahim, Kholoud F. Ghazawi, Samar F. Miski, Duaa Fahad ALsiyud, Shaimaa G. A. Mohamed and Gamal A. Mohamed
Mar. Drugs 2023, 21(4), 257; https://doi.org/10.3390/md21040257 - 21 Apr 2023
Viewed by 3224
Abstract
Marine sponges are multicellular and primitive animals that potentially represent a wealthy source of novel drugs. The genus Acanthella (family Axinellidae) is renowned to produce various metabolites with various structural characteristics and bioactivities, including nitrogen-containing terpenoids, alkaloids, and sterols. The current work provides [...] Read more.
Marine sponges are multicellular and primitive animals that potentially represent a wealthy source of novel drugs. The genus Acanthella (family Axinellidae) is renowned to produce various metabolites with various structural characteristics and bioactivities, including nitrogen-containing terpenoids, alkaloids, and sterols. The current work provides an up-to-date literature survey and comprehensive insight into the reported metabolites from the members of this genus, as well as their sources, biosynthesis, syntheses, and biological activities whenever available. In the current work, 226 metabolites have been discussed based on published data from the period from 1974 to the beginning of 2023 with 90 references. Full article
(This article belongs to the Special Issue Bio-Active Components from Marine Sponges)
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