Advanced Magnetic Nanomaterial for Cancer Therapy and Diagnosis

A special issue of Magnetochemistry (ISSN 2312-7481). This special issue belongs to the section "Magnetic Materials".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1697

Special Issue Editor


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Guest Editor
Institute of Chemical Biology and Fundamental Medicine, Biomedical Chemistry laboratory, Russian Academy of Sciences, Novosibirsk, Lavrentyev Ave. 8, Russia
Interests: biomedical Imaging; drug-delivery systems; theranostics; anti-cancer drugs; medicinal chemistry; nanomaterials; nanocomposites; nuclear magnetic resonance; magnetic resonance imaging
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Special Issue Information

Dear Colleagues,

Magnetic nanoparticles and nanocomposites are promising highly functionalizable tools for cancer diagnosis, monitoring, and therapy. Studying magnetic nanospecies’ structural features and coating procedures and stability opens up excellent prospects for multifunctional and bioinspired materials and devices. The influence of magnetic fields can be used as an exogenous stimulus to induce changes in the physical, chemical, and structural properties. Therefore, magnetic nanocomposites synthesis, conjugation strategies to apply bioinspired construction for diagnosis, and simultaneous therapy have been a feature of the last several years. New prospects in the theranostics area will lead to obtaining a promising tool for clinics.

This Special Issue is focused on the most recent advances in the synthesis, characterization, and optimization of magnetic nanoparticle properties, surface coating for enhanced stability, biocompatibility, and toxicity in various areas such as diagnostics, imaging, drug–gene delivery, and therapy of cancer.

Dr. Alexey Chubarov
Guest Editor

Manuscript Submission Information

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Keywords

  • nanotechnology
  • magnetic nanoparticles
  • nanocomposites
  • multifunctional materials
  • biomaterials
  • magnetic resonance imaging
  • magnetic hyperthermia
  • drug delivery
  • therapy
  • diagnostics
  • theranostics
  • coatings
  • biocompatibility
  • toxicity

Published Papers (1 paper)

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Research

13 pages, 2870 KiB  
Article
Low-Frequency Dynamic Magnetic Fields Decrease Cellular Uptake of Magnetic Nanoparticles
by Anna V. Ivanova, Nelly S. Chmelyuk, Aleksey A. Nikitin, Alexander G. Majouga, Vladimir P. Chekhonin and Maxim A. Abakumov
Magnetochemistry 2024, 10(2), 9; https://doi.org/10.3390/magnetochemistry10020009 - 1 Feb 2024
Viewed by 1312
Abstract
Magnetic nanoparticles have gained attention as a potential structure for therapy and diagnosing oncological diseases. The key property of the magnetic nanoparticles is the ability to respond to an external magnetic field. It is known that magnetofection causes an increase in the cellular [...] Read more.
Magnetic nanoparticles have gained attention as a potential structure for therapy and diagnosing oncological diseases. The key property of the magnetic nanoparticles is the ability to respond to an external magnetic field. It is known that magnetofection causes an increase in the cellular uptake of RNA and DNA in complexes with magnetic nanoparticles in the presence of a permanent magnetic field. However, the influence of a dynamic magnetic field on the internalization of MNPs is not clear. In this work, we propose the idea that applying external low-frequency dynamic magnetic fields may decrease the cellular uptake, such as macrophages and malignant neuroblastoma. Using fluorescence microscopy and atomic emission spectroscopy, we found that oscillating magnetic fields decreased the cellular uptake of magnetic nanoparticles compared to untreated cells by up to 46%. In SH-SY5Y tumor cells and macrophage RAW264.7 cells, the absolute values of Fe per cell differed by 0.10 pg/cell and 0.33 pg/cell between treated and untreated cells, respectively. These results can be applied in the control of the cellular uptake in different areas of biomedicine. Full article
(This article belongs to the Special Issue Advanced Magnetic Nanomaterial for Cancer Therapy and Diagnosis)
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