Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.7
3.2
Journals
Life
Special Issues
Photodynamic Diagnosis and Therapy
share announcement

Photodynamic Diagnosis and Therapy

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2021

Special Issue Editors

Prof. Dr. Aleksandra Kawczyk-Krupka

E-Mail Website
Guest Editor
Department of Internal Medicine, Angiology and Physical Medicine, Centre for Laser Diagnostics and Therapy, Medical University of Silesia in Katowice, 41-902 Bytom, Poland
Interests: photodynamic diagnosis; photodynamic therapy; angiology; internal disease; immunology; cell culture
Prof. Dr. David Aebisher

E-Mail Website
Guest Editor
Department of Photomedicine and Physical Chemistry, University of Rzeszów, 35-310 Rzeszow, Poland
Interests: photodynamic therapy; diagnostics; photosensitizers; treatment; drug delivery, fiber optics, singlet oxygen
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The subject of our research is consistently focused on clinical and basic research in photodynamic diagnostics (PDD) and therapy (PDT). One of the overriding and important goals of our research is to study the use of PDT in early diagnosis and treatment of pre-cancer and cancer. In this field, we have been conducting clinical trials for many years, and we are aiming to identify and understand the mechanism of action of photodynamic therapy in basic research on cancer cell lines. 

In this Special Issue, our interest is directed toward experimental and theoretical methods of organic photochemistry and photobiology, organic synthesis of photosensitizers, reactive intermediates, and design of singlet oxygen delivery devices (1O2). We welcome research on the pioneering use of fiber optics in medicine. Specifically, our topics of interest include issues related to the interaction of light with molecules, cells, and tissues, including research in the fields of chemistry, physics, biology, and medicine. In addition to PDT, papers can discuss luminescence, bioluminescence, chemiluminescence, and up-conversion as an alternative method of generating 1O2. Further, the important role of fluorescence-based methods for medical diagnosis is of interest to this Special Issue.

Prof. Dr. Aleksandra Kawczyk-Krupka
Prof. Dr. David Aebisher
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photodynamic therapy
  • photochemistry
  • photobiology
  • fiber optics
  • singlet oxygen
  • medicine

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 2141 KiB  
Article
Photosensitivity of Different Nanodiamond–PMO Nanoparticles in Two-Photon-Excited Photodynamic Therapy
by Nicolas Bondon, Denis Durand, Kamel Hadj-Kaddour, Lamiaa M. A. Ali, Rabah Boukherroub, Nadir Bettache, Magali Gary-Bobo, Laurence Raehm, Jean-Olivier Durand, Christophe Nguyen and Clarence Charnay
Life 2022, 12(12), 2044; https://doi.org/10.3390/life12122044 - 07 Dec 2022
Cited by 1 | Viewed by 1395
Abstract
Background: In addition to their great optical properties, nanodiamonds (NDs) have recently proved useful for two-photon-excited photodynamic therapy (TPE-PDT) applications. Indeed, they are able to produce reactive oxygen species (ROS) directly upon two-photon excitation but not with one-photon excitation; Methods: Fluorescent NDs (FNDs) [...] Read more.
Background: In addition to their great optical properties, nanodiamonds (NDs) have recently proved useful for two-photon-excited photodynamic therapy (TPE-PDT) applications. Indeed, they are able to produce reactive oxygen species (ROS) directly upon two-photon excitation but not with one-photon excitation; Methods: Fluorescent NDs (FNDs) with a 100 nm diameter and detonation NDs (DNDs) of 30 nm were compared. In order to use the gems for cancer-cell theranostics, they were encapsulated in a bis(triethoxysilyl)ethylene-based (ENE) periodic mesoporous organosilica (PMO) shell, and the surface of the formed nanoparticles (NPs) was modified by the direct grafting of polyethylene glycol (PEG) and amino groups using PEG-hexyltriethoxysilane and aminoundecyltriethoxysilane during the sol–gel process. The NPs’ phototoxicity and interaction with MDA-MB-231 breast cancer cells were evaluated afterwards; Results: Transmission electronic microscopy images showed the formation of core–shell NPs. Infrared spectra and zeta-potential measurements confirmed the grafting of PEG and NH2 groups. The encapsulation of the NDs allowed for the imaging of cancer cells with NDs and for the performance of TPE-PDT of MDA-MB-231 cancer cells with significant mortality. Conclusions: Multifunctional ND@PMO core–shell nanosystems were successfully prepared. The NPs demonstrated high biocompatibility and TPE-PDT efficiency in vitro in the cancer cell model. Such systems hold good potential for two-photon-excited PDT applications. Full article
(This article belongs to the Special Issue Photodynamic Diagnosis and Therapy)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop