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Life
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New Insights into Diagnosis and Pitfalls in the Treatment of...
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New Insights into Diagnosis and Pitfalls in the Treatment of Parotid Tumors

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 6009

Special Issue Editor

Dr. Tetsuya Terada

E-Mail Website
Guest Editor
Department of Otorhinolaryngology-Head and Neck Surgery, Osaka Medical and Pharmaceutical University, Takatsuki-City 569-8686, Japan
Interests: parotid tumors

Special Issue Information

Dear Colleagues,

Salivary gland neoplasms are relatively rare, with nearly 80% occurring in the parotid gland. Parotid carcinoma presents a considerable diagnostic challenge to the general pathologist, who is familiar with the various histological subtypes, immunohistochemical stains and common translocations. The role of the pathologist is crucial when deciding on a treatment strategy for parotid tumors, as it is essential to assess the histological type and grade prior to surgery. The clinical course varies according to tumor subtype, ranging from slowly progressing adenoid cystic carcinoma to rapidly progressing and in some cases fatal salivary gland duct carcinoma. Pathological diagnosis of the histological grade is also important in prognosis and treatment.

Surgery remains the mainstay of treatment when resection margins are negative and the key surgical technique is to remove the tumor completely and treat the facial nerve appropriately.

In this Special Issue, we would like to request the submission of original papers and reviews regarding the diagnosis and treatment strategy for the parotid tumor. We look forward to publishing your latest research for the parotid tumor

Dr. Tetsuya Terada
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • parotid gland
  • diagnosis
  • treatment
  • facial nerve
  • surgery

Published Papers (3 papers)

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Research

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11 pages, 702 KiB  
Article
Noteworthy Factors to Decide Therapeutic Strategy for Carcinoma ex Pleomorphic Adenoma of Parotid Gland: A Preliminary Study Statistical Analysis of 22 Cases from Single Institution
by Kosei Mori, Kazuki Yamasaki, Yuki Morimoto, Takashi Kinoshita, Shunichi Asai, Tomoyuki Arai, Tomohisa Iinuma, Syuji Yonekura and Toyoyuki Hanazawa
Life 2022, 12(11), 1685; https://doi.org/10.3390/life12111685 - 24 Oct 2022
Viewed by 1003
Abstract
Carcinoma ex pleomorphic adenoma (CXPA) is a rare malignant salivary gland tumor, and its prognosis is determined by the histological progression beyond the adenoma capsule. However, a preoperative evaluation of the histological progression remains challenging, and there is no consensus regarding treatment strategies [...] Read more.
Carcinoma ex pleomorphic adenoma (CXPA) is a rare malignant salivary gland tumor, and its prognosis is determined by the histological progression beyond the adenoma capsule. However, a preoperative evaluation of the histological progression remains challenging, and there is no consensus regarding treatment strategies for CXPA. Herein, we aimed to predict the histological progression preoperatively and develop an appropriate treatment strategy for CXPA. We retrospectively reviewed 22 patients with parotid gland CXPA recorded at our hospital. The clinicopathological characteristics were assessed, and survival analysis was performed. T3≤ or N+ were common in widely invasive CXPA (WICXPA) (p < 0.05). A tumor diameter > 40 mm and the N+ status were associated with poor prognosis considering overall survival (OS) and locoregional recurrence rate (LRC) (p < 0.05). Patients with facial nerve paralysis exhibited better OS and LRC than those without facial nerve paralysis. More than 90% of patients with WICXPA experienced distant metastases. Meanwhile, there were no cases of recurrence or death due to intracapsular and minimally invasive CXPA. A preoperative advanced T stage or N+ status was suspected as WICXPA. Tumors > 40 mm in size and N+ status necessitate high-intensity local treatment. Facial nerve invasion can be controlled by nerve resection. Postoperative systemic therapy could control distant metastases. Full article
(This article belongs to the Special Issue New Insights into Diagnosis and Pitfalls in the Treatment of Parotid Tumors)
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Review

Jump to: Research

9 pages, 967 KiB  
Review
Role of Intra-Parotid Lymph Node Metastasis in Primary Parotid Carcinoma
by Tetsuya Terada and Ryo Kawata
Life 2022, 12(12), 2053; https://doi.org/10.3390/life12122053 - 07 Dec 2022
Cited by 3 | Viewed by 1957
Abstract
The parotid gland contains intra-glandular lymph nodes, the distribution of which is crucial for understanding the pathogenesis of intra-parotid lymph node metastases of parotid carcinoma and other head and neck carcinomas. Positive intra-parotid lymph node metastasis predicts the risk of positive cervical nodal [...] Read more.
The parotid gland contains intra-glandular lymph nodes, the distribution of which is crucial for understanding the pathogenesis of intra-parotid lymph node metastases of parotid carcinoma and other head and neck carcinomas. Positive intra-parotid lymph node metastasis predicts the risk of positive cervical nodal metastasis. It is important to establish whether prophylactic neck dissection, including intra-parotid lymph nodes, contributes to treatment outcomes. The presence or absence of intra-parotid lymph nodes or metastasis-positive lymph nodes warrants further study. A preoperative diagnosis by imaging and fine-needle aspiration cytology of intra-parotid lymph nodes is difficult. Although intraoperative frozen section biopsy is performed during surgery, it is challenging to identify intra-parotid lymph nodes. The number of lymph nodes was the largest (47%) in the lower half of the superficial lobe, with 35% of nodes being concentrated in the inferior part of the cervicofacial branch, i.e., the lower pole of the parotid gland. Therefore, superficial parotidectomy and lower pole lobectomy need to be performed in cases in which a malignant tumor localizes to the superficial lobe or a lower pole. When intra-parotid lymph node metastases are detected during surgery, selective neck dissection (at least levels II and III) needs to be simultaneously performed. Full article
(This article belongs to the Special Issue New Insights into Diagnosis and Pitfalls in the Treatment of Parotid Tumors)
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14 pages, 1341 KiB  
Review
Fine-Needle Aspiration Cytology for Parotid Tumors
by Masataka Taniuchi, Tetsuya Terada and Ryo Kawata
Life 2022, 12(11), 1897; https://doi.org/10.3390/life12111897 - 15 Nov 2022
Cited by 2 | Viewed by 2658
Abstract
Fine-needle aspiration (FNA) cytology is widely used in clinical practice as a simple and minimally invasive test for parotid tumors that allows for preoperative estimation of benignancy and malignancy, histological type, and malignancy grade and can be performed on an outpatient basis. In [...] Read more.
Fine-needle aspiration (FNA) cytology is widely used in clinical practice as a simple and minimally invasive test for parotid tumors that allows for preoperative estimation of benignancy and malignancy, histological type, and malignancy grade and can be performed on an outpatient basis. In recent years, cell blocks prepared with core needle biopsy (CNB) and liquid-based cytology (LBC) have increased the reliability of immunostaining and molecular biological testing, leading to improved diagnostic accuracy. In 2018, the Milan System for Reporting Salivary Gland Cytology was introduced, but it does not include malignancy grade or histological type, so we proposed the Osaka Medical College classification as a more clinically based cell classification that includes both types of information, and we have reported on its usefulness. This review gives an overview of the history and use of FNA and describes CNB and LBC and the two classification systems. Full article
(This article belongs to the Special Issue New Insights into Diagnosis and Pitfalls in the Treatment of Parotid Tumors)
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