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Special Issue "Neural Stem Cells: Identity and Potential"
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 819
Special Issue Editor
Interests: neural stem cells; brain tumors
Special Issue Information
The amazing progress in the field of stem cell biology over the past several decades has transformed both science and biomedicine. Neural stem cells (NSCs) are the stem cells of the nervous system. Through the development process they produce the entire nervous system. In adults, a small number of NSCs persist, and they are mostly inactive; however, ample evidence supports their important roles in plasticity, aging, disease, and nervous system regeneration. Because NSCs are regulated both by intrinsic genetic and epigenetic programs and by extrinsic stimuli transduced through the stem cell niche, NSC dysregulation due to genetic causes or environmental impacts can lead to disease. Therefore, extensive research has been keen in recent decades with the aim of understanding how NSCs are controlled. On the other hand, since their discovery, NSCs have been a focal point for cell-based therapeutic strategies in the brain and spinal cord. NSCs are the optimal cells for central nervous system restoration as they can differentiate into mature cells and, most importantly, functional neurons and glial cells. However, their application is limited by multiple factors, such as difficult access to source material; limited number of cells; problematic, long and expensive cultivation in vitro; and ethical considerations. Although recent advances in embryonic and induced pluripotent stem cells have provided novel sources for NSCs, several challenges remain. In this Special Issue, we are looking for NSC leaders and experts to recapitulate our current understanding of NSC molecular regulation and the importance of NSCs for disease modelling and translational applications.
Dr. María Ángeles Marqués-Torrejón
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- neural stem cells
- neural development
- brain plasticity
- brain tumors