DNA Damage, Repair and Mutagenesis

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Genetics and Genomics".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 218

Special Issue Editor


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Guest Editor
IRB Barcelona-Institute for Research in Biomedicine, Barcelona, Spain
Interests: DNA damage and repair; genetic; genomic and epigenomic determinants of cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Damage to DNA occurs constantly due to the action of both metabolic and external agents. Incorrect repair can trigger genome instability and mutational events which, by compromising chromatin homeostasis, are the origin of some of the deadliest diseases, including cancer, neurodegenerative syndromes and other age-related disorders. This field is witnessing continuous development as the complexity of the factors, genetic, genomic and epigenomic, contributing to damage deposition and repair efficiency is unveiled. Yeast and lower metazoan models, such as S. cerevisiae, S. pombe or C. elegans, have set the basis for a detailed understanding of basic repair and damage tolerance pathways and the coordination of DNA metabolism processes such as replication, transcription and recombination. The utilization of rodent models and human cell lines, and also organoids or organ-on-a-chip systems, continues to reveal the relevance of the chromatin structure, ncRNA regulation, and gene expression changes in response to, and caused by, DNA damage; this is in addition to tissue specificities, and its relationship with metabolic network alterations and the microbiome. This Special Issue aims to offer a comprehensive and updated overview of the complexity of factors impacting the mechanisms determining the integrity of the genome, both in human and model systems.

Dr. Víctor González-Huici
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • genomics
  • epigenomics
  • genome instability
  • cancer
  • neurodegeneration
  • ageing
  • chemotherapy
  • replication
  • transcription
  • mutational signatures

Published Papers

This special issue is now open for submission.
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