Special Issue "Neurological and Psychiatric Diseases and Antipsychotic Treatment"

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 163

Special Issue Editors

Prof. Dr. Felix Martin Werner
E-Mail Website
Guest Editor
Institute of Neurosciences Human Medicine, University of Bonn, Bonn, Germany
Interests: psycho- and neuropharmacology
Special Issues, Collections and Topics in MDPI journals
Laboratory of Neuroanatomy of the Peptidergic Systems, Institute of Neuroscience of Castilla and León (INCYL), University of Salamanca, c/ Pintor Fernando Gallego 1, 37007 Salamanca, Spain
Interests: cancer and anticancer peptides; substance P/neurokinin-1 receptor system; neurokinin-1 receptor antagonists
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For several decades, antipsychotic drugs have been administered to patients with schizophrenia and affective diseases. These drugs improve psychotic and affective symptoms, and maintenance therapy is often necessary. Antipsychotic drugs are not a causal pharmacotherapy but a palliative pharmacological treatment. In the treatment of schizophrenic patients, antipsychotic drugs, above all, ameliorate positive schizophrenic symptoms and, less effectively, negative schizophrenic symptoms; however, they often cause extrapyramidal symptoms. One negative aspect of the treatment with antipsychotic drugs is that they deteriorate cognitive symptoms. Most antipsychotic drugs block specific dopaminergic and serotonergic receptors. In addition, second-generation antipsychotic drugs often increase blood sugar, blood pressure, and cholesterol and they have adverse cardiac effects.

In the development of newer antipsychotic drugs, the following questions should be answered:

Is the D2 dopaminergic receptor blockade always necessary to achieve a strong antipsychotic effect?

Can interactions with receptors other than the dopaminergic and serotonergic receptors have an antipsychotic effect?

Can antipsychotic drugs also improve cognitive functions and not deteriorate them?

Can antipsychotic drugs have fewer metabolic and cardiac adverse effects?

Can the occurrence of extrapyramidal symptoms be reduced by administering newer antipsychotic drugs?

Is there a method to choose the patients who can profit from being treated with a specific antipsychotic drug?

Have the newer antipsychotic drugs a sufficient therapeutic effect?

This Special Issue aims to contribute to answering the questions of whether newer antipsychotic drugs have a secure therapeutic effect, whether they better treat negative schizophrenic symptoms, whether they improve cognitive functions, whether they less often cause extrapyramidal symptoms, and whether they have fewer adverse effects upon metabolism and the heart function. Furthermore, the question will be answered whether patients can be chosen who profit from pharmacotherapy with a specific antipsychotic drug.

Prof. Dr. Felix Martin Werner
Prof. Dr. Rafael Coveñas Rodríguez
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • antipsychotic drug
  • extrapyramidal symptoms
  • D2 receptor
  • partial agonistic effect
  • positive schizophrenic symptom

Published Papers

There is no accepted submissions to this special issue at this moment.
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