Immunity in Viral or Bacterial Infections: 2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1595

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Guest Editor
College of Veterinary Medicine, Shandong Agricultural University, Tai’an 271018, China
Interests: mitophagy; immunity; viral infection; bacteria infection
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Special Issue Information

Dear Colleagues,

Biological immunity can refer to constitutive physical innate mechanisms, such as the physical protection afforded against infections by skin, the activity of natural killer (NK) cells against virus-infected cells, or the natural resistance of mice to the diphtheria toxin because of their absence of a receptor for that toxin. Immunity can also be innate but inducible, as in the antiviral state induced by exposure to double-stranded RNA (dsRNA). Finally, immunity to specific microbes can be acquired during the lifetime of an individual by infection or vaccination.

There are too many papers to study that concern immunity and viral or bacterial infections; however, we still do not know about some other processes of immunity in bacterial and viral infections in animals or humans as well as potential signaling mechanisms. Additionally, some “secrets” remain unknown in regard to the specific interactions between immune responses and bacterial or viral infections in animals and humans.

For the publication of the previous edition, please see:

In this research topic, we welcome manuscripts from the following subtopics:

  • Processes of immunity during infections in animals and humans;
  • Physiological role of immunity during animal and human infections;
  • The mechanism of activated or inhibited immune cell functions in animals and humans;
  • The relationship between immune responses and animals during infections in animals and humans;
  • Effects of supplemental trace elements, prebiotics, or probiotics on immunity in animal and human infectious diseases.

Dr. Jianzhu Liu
Guest Editor

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  • acquired immunity
  • innate immunity
  • viral infection
  • bacterial infection

Published Papers (1 paper)

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13 pages, 2442 KiB  
Secretory IgA-ETEC F5 Immune Complexes Promote Dendritic Cell Differentiation and Prime T Cell Proliferation in the Mouse Intestine
by Da Qin, Ying Li, Xiaoyan Chen, Liyang Li, Guihua Wang, Xilin Hou and Liyun Yu
Life 2023, 13(9), 1936; - 20 Sep 2023
Viewed by 1070
Although secretory IgA (SIgA) is the dominant antibody in mucosal secretions, the capacity of the SIgA–antigen complex to prime the activation of dendritic cells (DCs) and T cells in the intestinal epithelium is not well understood. To this end, the SIgA–ETEC F5 immune [...] Read more.
Although secretory IgA (SIgA) is the dominant antibody in mucosal secretions, the capacity of the SIgA–antigen complex to prime the activation of dendritic cells (DCs) and T cells in the intestinal epithelium is not well understood. To this end, the SIgA–ETEC F5 immune complexes (ICs) were prepared via Ni-NTA pull-down. After injecting the ICs into the intestines of SPF BALB/c mice, most ICs were observed in the Peyer’s patch (PP). We established a microfold (M) cell culture model in vitro for transport experiments and the inhibition test. To evaluate the priming effect of mucosal immunity, we employed the DC2.4 stimulation test, T lymphocyte proliferation assays, and cytokine detection assays. We found that the ICs were taken up via clathrin-dependent endocytosis through M cells. The high expression of costimulatory molecules CD86, CD80, and CD40 indicated that the ICs promoted the differentiation and maturation of DC2.4 cells. The stimulation index (SI) in the complex group was significantly higher than in the control group, suggesting that the ICs stimulated the proliferation of primed T cells. The secretion of some cytokines, namely TNF-α, IFN-γ, IL-2, IL-4, IL-5, and IL-6, in spleen cells from the immunized mice was upregulated. These results indicate that ETEC F5 delivery mediated by SIgA in PPs initiates mucosal immune responses. Full article
(This article belongs to the Special Issue Immunity in Viral or Bacterial Infections: 2nd Edition)
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