17 March 2023
Life | Hot Papers on Antibody-Based Treatment

Antibodies are immune proteins that mark the evolution of the host’s immune response to infection. In recent years, both passive and active immunotherapies based on antibodies have shown a growing potential. In this collection, the articles reported here demonstrate how important antibody-based therapies are, and therefore, that their clinical and laboratory research should continue to flourish, so to optimize their clinical use.

“The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections”
by Mohamed Moubarak, Keneth Iceland Kasozi, Helal F. Hetta, Hazem M. Shaheen, Abdur Rauf, Hayder M. Al-kuraishy, Safaa Qusti, Eida M. Alshammari, Emmanuel Tiyo Ayikobua, Fred Ssempijja et al.
Life 2021, 11(8), 734;  
Available online:

“Previous Humoral Immunity to the Endemic Seasonal Alphacoronaviruses NL63 and 229E Is Associated with Worse Clinical Outcome in COVID-19 and Suggests Original Antigenic Sin”
by Daniele Focosi, Angelo Genoni, Ersilia Lucenteforte, Silvia Tillati, Antonio Tamborini, Pietro Giorgio Spezia, Lorenzo Azzi, Andreina Baj and Fabrizio Maggi
Life 2021, 11(4), 298;
Available online:

“Use of Quantitative Dried Blood Spots to Evaluate the Post-Vaccination Level of Neutralizing Antibodies against SARS-CoV-2”
by Alexandre Marchand, Ingrid Roulland, Florian Semence, Olof Beck and Magnus Ericsson
Life 2021, 11(11), 1125;
Available online:

“BiTEs, DARTS, BiKEs and TriKEs—Are Antibody Based Therapies Changing the Future Treatment of AML?”
by Cecily Allen, Amer M. Zeidan and Jan Philipp Bewersdorf
Life 2021, 11(6), 465;
Available online:

“Generation of Antibodies against Foot-and-Mouth-Disease Virus Capsid Protein VP4 Using Hepatitis B Core VLPs as a Scaffold”
by Jessica Swanson, Rennos Fragkoudis, Philippa C. Hawes, Joseph Newman, Alison Burman, Anusha Panjwani, Nicola J. Stonehouse and Tobias J. Tuthill
Life 2021, 11(4), 338;
Available online:

“A Comparative and Comprehensive Review of Antibody Applications in the Treatment of Lung Disease”
by Yuefeng Wu and Hai Song
Life 2022, 12(1), 130;
Available online:

“Body Mass Index Influence for the Personalization of the Monoclonal Antibodies Therapy for Psoriasis”
by Flavia Anghel, Diana Nitusca and Patricia Cristodor
Life 2021, 11(12), 1316;
Available online:

“Serum C-X-C Chemokine Ligand 1 Levels in Patients with Systemic Sclerosis: Relationship of Clinical and Laboratory Observations to Anti-CD20 Monoclonal Antibody Administration”
by Ruriko Kawanabe, Ayumi Yoshizaki, Kazuki M. Matsuda, Hirohito Kotani, Teruyoshi Hisamoto, Yuta Norimatsu, Ai Kuzumi, Takemichi Fukasawa, Satoshi Ebata, Asako Yoshizaki-Ogawa et al.
Life 2022, 12(5), 646;
Available online:

“The Three Pillars of COVID-19 Convalescent Plasma Therapy”
by Massimo Franchini, Giancarlo Maria Liumbruno, Giorgio Piacentini, Claudia Glingani and Marco Zaffanello
Life 2021, 11(4), 354;
Available online:

“BNT162b2 SARS-CoV-2 Vaccination Elicits High Titers of Neutralizing Antibodies to Both B.1 and P.1 Variants in Previously Infected and Uninfected Subjects”
by Ilaria Vicenti, Francesca Gatti, Renzo Scaggiante, Adele Boccuto, Daniela Zago, Monica Basso, Filippo Dragoni, Saverio Giuseppe Parisi and Maurizio Zazzi
Life 2021, 11(9), 896;
Available online:


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