Psoriatic Arthritis and the Need to Personalize Diagnosis, Clinimetry, and Treatment

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 20 April 2024 | Viewed by 1513

Special Issue Editor


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Guest Editor
Rheumatology Clinic, Ospedale “Carlo Urbani”, Università Politecnica delle Marche, Jesi (Ancona), Italy
Interests: inflammatory arthritides; musculoskeletal pain; fibromyalgia; imaging; clinimetry

Special Issue Information

Dear Colleagues,

Psoriatic arthritis represents a condition whose clinical expressiveness can be extremely heterogeneous. The wide clinical variability often results in diagnostic pitfalls, hence the need for a personalized approach on multiple fronts: from the use of sophisticated imaging techniques, to clinimetry according to prevalent manifestations, to treatment. The high prevalence of coexisting fibromyalgia can complicate the evaluation of these patients.

With these issues as our focus, I am delighted to invite you to contribute to this Special Issue, aimed at emphasizing the need for personalization in the setting of psoriatic arthritis.   

Areas covered by this Special Issue (both original contributions and literature reviews are welcome) include, but are not limited to:

  • The use of imaging techniques in the diagnosis of psoriatic arthritis and its major manifestations (synovitis, enthesitis, dactylitis, axial involvement);
  • The clinimetric approach with reference to inflammatory manifestations and disease impact on quality of life;
  • The burden of comorbidities, including fibromyalgia among them;
  • Therapeutic personalization.

I look forward to your contribution.

Best regards,

Dr. Marco Di Carlo
Guest Editor

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Keywords

  • psoriatic arthritis
  • imaging
  • synovitis
  • dactylitis
  • enthesitis
  • comorbidities
  • clinimetry
  • biologic DMARDs
  • targeted synthetic DMARDs

Published Papers (1 paper)

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Research

15 pages, 1417 KiB  
Article
The Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts): Measurement Properties of a New Multidimensional Composite Tool for the Quick Assessment of the Overall Health Status in Psoriatic Arthritis
by Fausto Salaffi, Marina Carotti, Sonia Farah and Marco Di Carlo
J. Pers. Med. 2023, 13(7), 1153; https://doi.org/10.3390/jpm13071153 - 18 Jul 2023
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Abstract
Background: Psoriatic arthritis (PsA) is a heterogeneous condition that is difficult to assess. The goal of this research was to evaluate the clinimetric properties of the Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts), a new patient-reported outcome (PRO) to measure the overall health status in [...] Read more.
Background: Psoriatic arthritis (PsA) is a heterogeneous condition that is difficult to assess. The goal of this research was to evaluate the clinimetric properties of the Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts), a new patient-reported outcome (PRO) to measure the overall health status in PsA patients. Methods: The PsA-5Ts were compared to composite measures of disease activity (DAPSA, PASDAS, CPDAI) and PROs (PsAID-12 and SF-36). The convergent validity was assessed through the Spearman’s correlation coefficient and the discriminant validity through the receiver operating characteristic (ROC) curve analysis, applying the Minimal Disease Activity (MDA) as an external criterion. Results: The cross-sectional assessment included 155 patients. Significant high correlations were observed when comparing PsA-5Ts to composite indices of disease activity and PROs (all at significance levels of p < 0.0001). The PsA-5Ts subscales were highly significantly different in terms of MDA status (all at p < 0.0001). The PsA-5Ts had good discriminant validity like that of the DAPSA, CPDAI, PASDAS, and PsAID-12, and better than that of the SF-36, with an area under the ROC curve of 0.944 (65% CI 0.895–0.974). Conclusions: The PsA-5Ts are an easy-to-use PRO that can be integrated with disease activity indices in the assessment of PsA in daily clinical practice. Full article
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