Current Status and Future Research in Otorhinolaryngology

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 7095

Special Issue Editors

Department of Biomedicine, Neuroscience and Advanced Diagnostics, Azienda Ospedaliera Universitaria Policlinico ''Paolo Giaccone'', University of Palermo, Via del Vespro, 133, 90127 Palermo, Italy
Interests: head and neck surgery; salivary gland surgery; sinus surgery; laryngeal surgery
Department of Biomedicine, Neuroscience and Advanced Diagnostics, Azienda Ospedaliera Universitaria Policlinico ''Paolo Giaccone'', University of Palermo, Via del Vespro, 133, 90127 Palermo, Italy
Interests: larynx; rhinology; otology; audiology; phoniatry
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Special Issue Information

Dear Colleagues,

The amount of recent research and advances in otorhinolaryngology is high, and therefore, the authors present in this Special Issue recent advances and current treatment options in the field.

The purpose of this Special Issue is to describe recent advances in otorhinolaryngology, including new diagnostic technological resources and surgical modalities. A resource such as this will be a very useful addition to the otolaryngologist's basic literary armamentarium, as it highlights advances in areas to guide further study. For this reason, we ask that you send in your most recent research on diagnosis and therapy.

Trusting in your participation, we send you my best regards.

Dr. Francesco Lorusso
Prof. Dr. Francesco Dispenza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advances in otorhinolaryngology
  • advances in ENT surgery
  • advances in ENT diagnostics
  • advances in ENT therapy
  • advances in head and neck surgery
  • advances in pediatric otorhinolaryngology

Published Papers (2 papers)

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Research

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10 pages, 1150 KiB  
Article
A Prospective Observational Study on the Role of Immunohistochemical Expression of Orphanin in Laryngeal Squamous Cell Carcinoma Recurrence
by Federico Sireci, Francesco Lorusso, Francesco Dispenza, Angelo Immordino, Salvatore Gallina, Pietro Salvago, Francesco Martines, Giuseppe Bonaventura, Maria Laura Uzzo and Giovanni Francesco Spatola
J. Pers. Med. 2023, 13(8), 1211; https://doi.org/10.3390/jpm13081211 - 30 Jul 2023
Cited by 4 | Viewed by 1089
Abstract
To date, histological biomarkers expressed by laryngeal cancer are poorly known. The identification of biomarkers associated with laryngeal squamous cell carcinoma (SCC), would help explain the tumorogenesis and prevent the possible recurrence of the lesion after treatment. For this reason, the aim of [...] Read more.
To date, histological biomarkers expressed by laryngeal cancer are poorly known. The identification of biomarkers associated with laryngeal squamous cell carcinoma (SCC), would help explain the tumorogenesis and prevent the possible recurrence of the lesion after treatment. For this reason, the aim of this study is to investigate, for the first time, the Orphanin expression in 48 human specimens of laryngeal SCC and evaluate its possible correlation with patients prognosis. We analyzed pathological specimens from 48 patients with laryngeal SCC to detect the presence of Orphanin by using an immunohistochemistry test. We compared the findings with healthy tissue acquired from patients who underwent surgery for mesenchymal benign tumours of the larynx. The specimens were stained with anti-Orphanin monoclonal antibodies. Results were processed through a computerised image analysis system to determine a scale of staining intensity. All the tumoural specimens examined showed a significant immunoreaction for Orphanin when compared with healthy tissues (p < 0.05) but with a different immune reactivity related to clinical-pathological features. A high Orphanin expression was not significantly related to Histological Grading (HG), TNM, and stage (p > 0.05). In the multivariate analysis, the Orphanin expression was significantly related only to the malignant recurrence (p < 0.05). Our study suggests that Orphanin could have a role in tumorigenesis by increasing the recurrence of cancer; therefore, it should be further explored as a possible biomarker for laryngeal cancer. Full article
(This article belongs to the Special Issue Current Status and Future Research in Otorhinolaryngology)
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Review

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15 pages, 3236 KiB  
Review
ARIA Care Pathways 2019: Next-Generation Allergic Rhinitis Care and Allergen Immunotherapy in Malaysia
by Amir Hamzah Abdul Latiff, Salina Husain, Baharudin Abdullah, Palaniappan Suppiah, Vincent Tan, Tang Ing Ping, Kent Woo, Yoke-Yeow Yap, Claus Bachert, Holger J. Schunemann, Anna Bedbrook, Wienczyslawa Czarlewski and Jean Bousquet
J. Pers. Med. 2023, 13(5), 835; https://doi.org/10.3390/jpm13050835 - 15 May 2023
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Abstract
An increase in the prevalence of allergic rhinitis (AR) worldwide presents a significant burden to the health care system. An initiative was started in Europe designated as Allergic Rhinitis and Its Impact on Asthma (ARIA) to develop internationally applicable guidelines by utilising an [...] Read more.
An increase in the prevalence of allergic rhinitis (AR) worldwide presents a significant burden to the health care system. An initiative was started in Europe designated as Allergic Rhinitis and Its Impact on Asthma (ARIA) to develop internationally applicable guidelines by utilising an evidence-based approach to address this crucial issue. The efforts are directed at empowerment of patients for self-management, the use of digital mobile technology to complement and personalise treatment, and establishment of real-life integrated care pathways (ICPs). This guideline includes aspects of patients’ and health care providers’ management and covers the main areas of treatment for AR. The model provides better real-life health care than the previous traditional models. This review summarises the ARIA next-generation guideline in the context of the Malaysian health care system. Full article
(This article belongs to the Special Issue Current Status and Future Research in Otorhinolaryngology)
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