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Recent Advances in Orthopaedic Surgery and Pathogenesis
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Recent Advances in Orthopaedic Surgery and Pathogenesis

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 15730

Special Issue Editor

Dr. Kun Wang

E-Mail Website
Guest Editor
Department of Joint and Trauma Surgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Interests: joint arthroplasty; arthritis; arthroscopy; biomechanics; musculoskeletal anatomy; three-dimensional reconstruction

Special Issue Information

Dear Colleagues,

Understanding musculoskeletal pathogenesis and identifying novel surgery approaches in orthopedic medicine remains in progress. There are numerous fields of innovation that bring remarkable progress to our knowledge of disease pathogenesis and have a considerable impact on the advancement of surgical techniques for clinical practice.

This Special Issue in the Journal of Personalized Medicine aims to highlight recent advances in orthopedic surgery and related musculoskeletal pathogenesis. The scope of this Special Issue is to report and characterize new technologies to assist orthopedic surgery, individualized design, and personalized treatment, or the current state of the utilization of cellular/animal models for improved understanding of the underlying mechanism in musculoskeletal pathogenesis. Recent research describing cutting-edge areas including 3D reconstruction surgical planning assistance, computer-assisted surgical procedures, and biomimetic medical devices is of interest.

We encourage the submission of papers that are focused on the field of recent advances in orthopedic surgery, and translation models which have the potential to be useful for personalized medical treatment in musculoskeletal pathogenesis. Original research papers and reviews which describe a personalized medicine approach to the diagnosis, classification, medical devices, and anatomical biomechanics related to orthopedic diseases are also welcome.

Dr. Kun Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • orthopedic surgery
  • synovial joint
  • bone joint pathogenesis
  • musculoskeletal biomechanics
  • anatomy
  • medical devices
  • 3D reconstruction
  • biomarkers
  • trauma surgery
  • tissue repair
  • animal models

Published Papers (5 papers)

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Research

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12 pages, 707 KiB  
Article
Tramadol May Increase Risk of Hip Fracture in Older Adults with Post-Traumatic Osteoarthritis
by Ting-Yu Wu, Wen-Tien Wu, Ru-Ping Lee, Ing-Ho Chen, Tzai-Chiu Yu, Jen-Hung Wang and Kuang-Ting Yeh
J. Pers. Med. 2023, 13(4), 580; https://doi.org/10.3390/jpm13040580 - 26 Mar 2023
Cited by 1 | Viewed by 6564
Abstract
Tramadol, an analgesic widely used for arthritic pain, is known to have adverse effects. This study investigated the association between the long-term use of tramadol for pain control and subsequent hip fractures in patients aged 60 years or older with posttraumatic osteoarthritis. This [...] Read more.
Tramadol, an analgesic widely used for arthritic pain, is known to have adverse effects. This study investigated the association between the long-term use of tramadol for pain control and subsequent hip fractures in patients aged 60 years or older with posttraumatic osteoarthritis. This population-based retrospective cohort study included patients with posttraumatic osteoarthritis who received tramadol for pain control for more than 90 days within a 1-year period. A control cohort was enrolled using propensity score matching. The primary outcome was a new diagnosis of hip fracture requiring surgery. In total, 3093 patients were classified into each cohort. Tramadol use was identified as a risk factor for hip fracture (adjusted hazard ratio (aHR): 1.41; 95% confidence interval (CI): 1.09–1.82; p = 0.008), especially among patients aged 60–70 years (aHR: 2.11; 95% CI: 1.29–3.47; p = 0.003) and among male patients (aHR: 1.83; 95% CI: 1.24–2.70; p = 0.002). This is the first cohort study focusing on the association between long-term tramadol use and hip fracture among older adults with posttraumatic osteoarthritis. Tramadol, as a long-term pain control analgesic for older adults with posttraumatic osteoarthritis, may increase the risk of hip fracture, especially among male patients and those aged 60–70 years. Full article
(This article belongs to the Special Issue Recent Advances in Orthopaedic Surgery and Pathogenesis)
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8 pages, 2646 KiB  
Article
Treatment of Calcific Insertional Achilles Tendinopathy: Knotless Internal Brace versus Knot-Tying Suture Bridge
by Xiaodong Zhao, Xiaolei Yang, Yifan Hao, Fujun Yang, Zhenping Zhang, Qirong Qian, Peiliang Fu and Qi Zhou
J. Pers. Med. 2023, 13(3), 404; https://doi.org/10.3390/jpm13030404 - 24 Feb 2023
Cited by 1 | Viewed by 2632
Abstract
Background: This study aimed to compare the knotless internal brace technique and the knot-tying suture bridge technique via the medial approach in the treatment of calcific Achilles tendinopathy. Methods: The clinical data of 25 cases of calcific Achilles tendinopathy in which nonoperative treatments [...] Read more.
Background: This study aimed to compare the knotless internal brace technique and the knot-tying suture bridge technique via the medial approach in the treatment of calcific Achilles tendinopathy. Methods: The clinical data of 25 cases of calcific Achilles tendinopathy in which nonoperative treatments had failed were retrospectively collected. All the patients received Achilles tendon debridement and Haglund deformity excision through a medial approach, followed by repair using the knotless internal brace technique or the knot-tying suture bridge technique. Pain was evaluated by using the visual analog scale (VAS). The American Orthopedic Foot and Ankle Score (AOFAS) questionnaire was administered preoperatively and postoperatively. Results: The mean follow-up time was 2.6 (range 2–3.5) years. There were no wound complications and no Achilles tendon ruptures. At 1 year postoperatively, the internal brace group was superior to the suture bridge group in terms of the VAS scores (p = 0.003). However, no differences were noticed between the two groups in either the VAS or the AOFAS scores at 2 years postoperatively. Conclusions: The medial approach in combination with the suture bridge technique was effective in treating calcific Achilles tendinopathy. The knotless internal brace technique involved less pain compared to the knot-tying suture bridge technique only at the early postoperative stage. Full article
(This article belongs to the Special Issue Recent Advances in Orthopaedic Surgery and Pathogenesis)
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8 pages, 1095 KiB  
Article
A Comparison of Negative Pressure and Conventional Therapy in Spine Infections: A Single-Center Retrospective Study
by Wenqiang Xing, Yang Yang, Yun Bai, Xiuchun Yu and Zhengqi Chang
J. Pers. Med. 2023, 13(2), 162; https://doi.org/10.3390/jpm13020162 - 17 Jan 2023
Cited by 2 | Viewed by 1376
Abstract
Purpose: To investigate the effectiveness and safety of negative-pressure wound therapy (NPWT) in treating primary spinal infections. Methods: Patients who underwent surgical treatment for primary spinal infection between January 2018 and June 2021 were retrospectively evaluated. They were divided into two groups based [...] Read more.
Purpose: To investigate the effectiveness and safety of negative-pressure wound therapy (NPWT) in treating primary spinal infections. Methods: Patients who underwent surgical treatment for primary spinal infection between January 2018 and June 2021 were retrospectively evaluated. They were divided into two groups based on the type of surgery: one that underwent negative-pressure wound therapy (NPWT) and another that underwent conventional surgery (CVSG-Posterior debridement, bone grafting, fusion, and internal fixation in one stage). The two groups were compared in terms of the total operation time, total blood loss, total postoperative drainage, postoperative pain score, time for the postoperative erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) to return to normal, postoperative complications, treatment time, and recurrence rate. Results: A total of 43 cases of spinal infection were evaluated, with 19 in the NPWT group and 24 in the CVSG group. The NPWT group had a superior postoperative drainage volume, antibiotic use time, erythrocyte sedimentation rate and CRP recovery times, VAS score at 3 months after the operation, and cure rate at 3 months after operation compared with the CVSG group. There were no significant variations in the total hospital stay and intraoperative blood loss between the two groups. Conclusions: This study supports the use of negative pressure in the treatment of a primary spinal infection and indicates that it has a notably better short-term clinical effect than conventional surgery. Additionally, its mid-term cure rate and recurrence rate are more desirable than those of conventional treatments. Full article
(This article belongs to the Special Issue Recent Advances in Orthopaedic Surgery and Pathogenesis)
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10 pages, 4212 KiB  
Article
Comparison of Pedicled Adductor Longus and Pedicled Sartorius Flap in Inguinal Reconstruction, a Fresh Cadaver Study
by Hong Zhang, Zhenfeng Li, Jianmin Li, Binghong Zhu and Qingjia Xu
J. Pers. Med. 2023, 13(1), 143; https://doi.org/10.3390/jpm13010143 - 11 Jan 2023
Cited by 1 | Viewed by 1394
Abstract
Reconstruction surgeries in the inguinal area are challenging for vascular surgeons, oncologists, orthopedists, and others. The pedicled sartorius flap is the most commonly used flap for reconstruction. The pedicled adductor longus is reported as a new method to reconstruct the inguinal region. The [...] Read more.
Reconstruction surgeries in the inguinal area are challenging for vascular surgeons, oncologists, orthopedists, and others. The pedicled sartorius flap is the most commonly used flap for reconstruction. The pedicled adductor longus is reported as a new method to reconstruct the inguinal region. The related anatomic study is rare. This work aims to make a comparison of pedicled adductor longus and pedicled sartorius on cadavers for better use. Out of the 12 thighs in the 6 cadavers analyzed, the author compares two surgical methods in terms of surgical details, exposure of vascular and nerve pedicle, flap harvesting, flap transposition and flap volume, etc. Through the course of this study, it is showed that the adductor longus flap had a sizable advantage over the sartorius flap in terms of exposure, harvesting, and flap volume. Full article
(This article belongs to the Special Issue Recent Advances in Orthopaedic Surgery and Pathogenesis)
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10 pages, 1519 KiB  
Case Report
Ultrasound-Guided Injection of Autologous Platelet-Rich Plasma for Refractory Lateral Epicondylitis of Humerus: Case Series
by Guohang Huang, Jiangshan Zhang, Zhenhai Wei, Yiying Mai, Jisheng Guo and Li Jiang
J. Pers. Med. 2023, 13(1), 66; https://doi.org/10.3390/jpm13010066 - 28 Dec 2022
Cited by 2 | Viewed by 2992
Abstract
Refractory lateral epicondylitis (RLE) is a tendinopathy of the elbow with less effective conservation treatment. Platelet-rich plasma (PRP) is a new treatment option for RLE because of its repair-promoting effect on tissues. Although evidence demonstrates the efficacy of PRP in treating tendinopathies, the [...] Read more.
Refractory lateral epicondylitis (RLE) is a tendinopathy of the elbow with less effective conservation treatment. Platelet-rich plasma (PRP) is a new treatment option for RLE because of its repair-promoting effect on tissues. Although evidence demonstrates the efficacy of PRP in treating tendinopathies, the therapeutic utility of ultrasound-guided PRP injection for RLE is unknown. Here, we report two cases of RLE treated with PRP. The first patient was a 78-year-old man who received an unknown dose of local glucocorticoid injection at the local community clinic in June 2016. His pain recurred after exertion. The second patient was a 54-year-old woman who received a glucocorticoid injection (0.5 mL of compound betamethasone and 1.5 mL of 0.9% normal saline) in October 2020. Her pain could not be relieved. A physician diagnosed patients with RLE based on their medical history, symptoms, and clinical signs. The doctor injected PRP (the first patient in November 2020, the second in March 2021) under ultrasound guidance into the patient’s attachment point of the extensor tendon at the lateral humeral epicondyle. The doctor evaluated the effectiveness of the treatment by ultrasonography, visual analogue scale, and the patient-rated tennis elbow evaluation. After four weeks of treatment, the pain was relieved, and functions continued to improve in the following three months. Moreover, the ultrasonography showed that the damaged tendons were repaired. Together, we demonstrate that ultrasound-guided PRP injection could considerably relieve pain, improve elbow joint functions in patients with RLE, and provide visible evidence that PRP repairs tendon damage. Full article
(This article belongs to the Special Issue Recent Advances in Orthopaedic Surgery and Pathogenesis)
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