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The Challenges and Therapeutic Prospects in Autoimmune Diseases
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The Challenges and Therapeutic Prospects in Autoimmune Diseases

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (25 March 2024) | Viewed by 9902

Special Issue Editors

Prof. Dr. Cristian Baicus

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Guest Editor
Department of Internal Medicine, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy Bucharest, Bucharest, Romania
Interests: diagnostic studies; fever of unknown origin; inflammation of unknown origin; systemic lupus erythematosus; large vessel vasculitis
Dr. Camelia Badea

E-Mail Website
Guest Editor
Department of Internal Medicine, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy Bucharest, Bucharest, Romania
Interests: systemic lupus erythematosus; large vessel vasculitis; Sjogren’s syndrome; autoinflamatory disease
Dr. Razvan Adrian Ionescu

E-Mail Website
Guest Editor
Department of Internal Medicine, Colentina Clinical Hospital, Carol Davila University of Medicine and Pharmacy Bucharest, Bucharest, Romania
Interests: spondylarthritis; rheumatoid arthritis; crystal-induced arthritis; musculoskeletal untrasonography

Special Issue Information

Dear Colleagues,

Autoimmune diseases are rare diseases with single-organ or multisystemic impact that can cause a lot of damage. Moreover, being rare diseases, most of the time there is no valid evidence concerning their treatment. Frequently, there is no accurate test for their diagnosis either, and the diagnosis is made using far from perfect criteria, or by exclusion.

The treatment landscape of this kind of disease has evolved during the last 25 years, as new knowledge and new technologies have emerged that led to the appearance of new drug classes. Nevertheless, as the treatment of autoimmune diseases almost always involves immunosuppressive drugs, patients may easily contract infections, and sometimes it is hard to differentiate the infection from a disease flare-up. This raises other problems with respect to the treatment of such patients.

These are some of the challenges of autoimmune diseases. This Special Issue welcomes original research papers, systematic reviews, or narrative reviews addressing fundamental, translational, and clinical aspects from this domain (mechanisms of disease, animal models, epidemiology, risk or protection factors, diagnostic, prognostic, remission, or flare definition, treatment).

Prof. Dr. Cristian Baicus
Dr. Camelia Badea
Dr. Razvan Adrian Ionescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autoimmune diseases
  • animal models
  • translational research
  • diagnostic research
  • prognostic research
  • therapy

Published Papers (3 papers)

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Research

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25 pages, 4939 KiB  
Article
Immune Portrayal of a New Therapy Targeting Microbiota in an Animal Model of Psoriasis
by Mihaela Surcel, Carolina Constantin, Adriana Narcisa Munteanu, Diana Antonia Costea, Gheorghița Isvoranu, Elena Codrici, Ionela Daniela Popescu, Cristiana Tănase, Alef Ibram and Monica Neagu
J. Pers. Med. 2023, 13(11), 1556; https://doi.org/10.3390/jpm13111556 - 30 Oct 2023
Viewed by 953
Abstract
Background: Despite all the available treatments, psoriasis remains incurable; therefore, finding personalized therapies is a continuous challenge. Psoriasis is linked to a gut microbiota imbalance, highlighting the importance of the gut–skin axis and its inflammatory mediators. Restoring this imbalance can open new perspectives [...] Read more.
Background: Despite all the available treatments, psoriasis remains incurable; therefore, finding personalized therapies is a continuous challenge. Psoriasis is linked to a gut microbiota imbalance, highlighting the importance of the gut–skin axis and its inflammatory mediators. Restoring this imbalance can open new perspectives in psoriasis therapy. We investigated the effect of purified IgY raised against pathological human bacteria antibiotic-resistant in induced murine psoriatic dermatitis (PSO). Methods: To evaluate the immune portrayal in an imiquimod experimental model, before and after IgY treatment, xMAP array and flow cytometry were used. Results: There were significant changes in IL-1α,β, IL-5, IL-6, IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17a, IFN-γ, TNF-α, IP-10/CXCL10, MCP-1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, MIG/CXCL9, and KC/CXCL1 serum levels. T (CD3ε+), B (CD19+) and NK (NK1.1+) cells were also quantified. In our model, TNF-α, IL-6, and IL-1β cytokines and CXCL1 chemokine have extremely high circulatory levels in the PSO group. Upon experimental therapy, the cytokine serum values were not different between IgY-treated groups and spontaneously remitted PSO. Conclusions: Using the murine model of psoriatic dermatitis, we show that the orally purified IgY treatment can lead to an improvement in skin lesion healing along with the normalization of cellular and humoral immune parameters. Full article
(This article belongs to the Special Issue The Challenges and Therapeutic Prospects in Autoimmune Diseases)
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Review

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31 pages, 1401 KiB  
Review
The Spectrum of Extraglandular Manifestations in Primary Sjögren’s Syndrome
by Ancuta Mihai, Constantin Caruntu, Ciprian Jurcut, Florin Cristian Blajut, Mihnea Casian, Daniela Opris-Belinski, Ruxandra Ionescu and Ana Caruntu
J. Pers. Med. 2023, 13(6), 961; https://doi.org/10.3390/jpm13060961 - 07 Jun 2023
Cited by 2 | Viewed by 3280
Abstract
Extraglandular manifestations (EGMs) in primary Sjogren’s syndrome (pSS) represent the clinical expression of the systemic involvement in this disease. EGMs are characterized by a wide heterogeneity; virtually any organ or system can be affected, with various degrees of dysfunction. The existing gaps of [...] Read more.
Extraglandular manifestations (EGMs) in primary Sjogren’s syndrome (pSS) represent the clinical expression of the systemic involvement in this disease. EGMs are characterized by a wide heterogeneity; virtually any organ or system can be affected, with various degrees of dysfunction. The existing gaps of knowledge in this complex domain of extraglandular extension in pSS need to be overcome in order to increase the diagnostic accuracy of EGMs in pSS. The timely identification of EGMs, as early as from subclinical stages, can be facilitated using highly specific biomarkers, thus preventing decompensated disease and severe complications. To date, there is no general consensus on the diagnostic criteria for the wide range of extraglandular involvement in pSS, which associates important underdiagnosing of EGMs, subsequent undertreatment and progression to severe organ dysfunction in these patients. This review article presents the most recent basic and clinical science research conducted to investigate pathogenic mechanisms leading to EGMs in pSS patients. In addition, it presents the current diagnostic and treatment recommendations and the trends for future therapeutic strategies based on personalized treatment, as well as the latest research in the field of diagnostic and prognostic biomarkers for extraglandular involvement in pSS. Full article
(This article belongs to the Special Issue The Challenges and Therapeutic Prospects in Autoimmune Diseases)
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14 pages, 1122 KiB  
Systematic Review
Causes of Polyserositis: A Systematic Review
by Laura Elena Stoichitoiu, Georgeta Daniela Ionescu, Ingrid Neatu and Cristian Baicus
J. Pers. Med. 2023, 13(5), 834; https://doi.org/10.3390/jpm13050834 - 15 May 2023
Cited by 3 | Viewed by 5130
Abstract
At present, polyserositis (PS) remains a challenging entity, which resides both in the fact that there is confusion regarding the terminology, and that it is still understudied. We aimed to identify the etiologies of PS, reported in adult patients. Methods: We performed a [...] Read more.
At present, polyserositis (PS) remains a challenging entity, which resides both in the fact that there is confusion regarding the terminology, and that it is still understudied. We aimed to identify the etiologies of PS, reported in adult patients. Methods: We performed a systematic review of the literature on PubMed(MEDLINE) database, using the following (MESH) terms: pleurisy/etiology, pleural effusion/etiology, pericarditis/etiology, pericardial effusion/etiology, pericardial effusion chronic, ascites/etiology, ascitic fluid/etiology, polyserositis, serositis, and serositides. Results: A total of 1979 articles were identified, dating from 1973 onwards. After screening the articles, we included 114 patients from 23 articles (one case series including 92 patients and 22 case reports) in the final report. The most common diagnosis was neoplasia (30; 26.3%), followed by autoimmune diseases (19, 16.7%) and infections (16, 12.3%). Still, in 35 cases, the etiology of PS remained unkown. Conclusion: PS is a challenging and understudied entity, which is associated with a wide range of diagnoses. However, prospective studies should be developed in order to have a clear understanding regarding its etiologies and their prevalences. Full article
(This article belongs to the Special Issue The Challenges and Therapeutic Prospects in Autoimmune Diseases)
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