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Special Issues
Multidisciplinary and Personalized Approach for Post-COVID-19 Syndrome
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Multidisciplinary and Personalized Approach for Post-COVID-19 Syndrome

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Epidemiology".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 4122

Special Issue Editors

Prof. Dr. Antigona Carmen Trofor

E-Mail Website
Guest Editor
Department of Pulmonology, University of Medicine and Pharmacy "Grigore T. Popa", Iasi, Romania
Interests: public health; epidemiology; SARS-COV2 infection; pneumology; COVID-19
Prof. Dr. Roxana Maria Nemes

E-Mail Website
Guest Editor
Department of Pathophysiology, Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania
Interests: COVID-19; multidisciplinarity; long-term effects; multisystemic impairment; chronic complications; management

Special Issue Information

Dear Colleagues,

In the current context, an increasingly clear outline of the impact of COVID-19 (coronavirus disease 2019) is being elucidated, alongside a new category of patients, namely, post-COVID-19 patients, a condition defined at more than 12 weeks after the acute viral episode by the persistence of clinical, imagistic and lung function changes (however, other unrevealed long-term health consequences may yet arise). The data that have become available after SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) was declared a global pandemic have shown that many of these patients return to the hospital with multiple symptoms and dysfunctions more than 6–12 months after the initial diagnosis. The most frequent complications that occur, both in the acute phase and at distance from the acute viral episode, include cardiovascular (myocarditis, arrhythmias), respiratory (pulmonary fibrosis, pulmonary arterial hypertension), metabolic (hyperglycaemia, dyslipidemia), musculoskeletal (reactive arthritis), and psychiatric (depression, post-traumatic stress syndrome) problems. With the multitude of ongoing scientific data and evidence, as well as frequent emerging controversies, constant updates are required in the field in order to characterize this exceptional global health situation. This Special Issue of the Journal of Personalized Medicine wishes to emphasize the importance of carefully following the evolution of patients with post-COVID-19 syndrome in order to be able to foresee and identify all potential complications and minimize long-term effects. In addition, considering the multisystemic impairment following COVID-19, patient follow-up will require a multidisciplinary approach, integrating pulmonology, pulmonary rehabilitation, cardiology, neurological, nephrological, and psychiatric consultations, perhaps with other specialists on a case-to-case basis, with the main objective being to ensure the best care and anticipate the appearance of long-term sequelae in order to develop personalized strategies to optimize the management of patients with post-COVID-19 syndrome.

Prof. Dr. Antigona Carmen Trofor
Prof. Dr. Roxana Maria Nemes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • COVID-19
  • multidisciplinarity
  • long-term effects
  • multisystemic impairment
  • chronic complications
  • management

Published Papers (3 papers)

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Research

12 pages, 953 KiB  
Article
Cardiac Autonomic Function and Functional Capacity in Post-COVID-19 Individuals with Systemic Arterial Hypertension
by Edelvita Fernanda Duarte Cunha, Matheus Sobral Silveira, Juliana Cristina Milan-Mattos, Heitor Fernandes Silveira Cavalini, Ádrya Aryelle Ferreira, Joice de Souza Batista, Lara Cazé Uzumaki, João Paulo Coelho Guimarães, Pedro Igor Lustosa Roriz, Fabianne Maisa de Novaes Assis Dantas, Arto J. Hautala, Raphael Martins de Abreu, Aparecida Maria Catai, Paulo Adriano Schwingel and Victor Ribeiro Neves
J. Pers. Med. 2023, 13(9), 1391; https://doi.org/10.3390/jpm13091391 - 18 Sep 2023
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Abstract
Individuals diagnosed with systemic arterial hypertension (SAH) are considered risk groups for COVID-19 severity. This study assessed differences in cardiac autonomic function (CAF) and functional capacity (FC) in SAH individuals without COVID-19 infection compared to SAH individuals post-COVID-19. Participants comprised 40 SAH individuals [...] Read more.
Individuals diagnosed with systemic arterial hypertension (SAH) are considered risk groups for COVID-19 severity. This study assessed differences in cardiac autonomic function (CAF) and functional capacity (FC) in SAH individuals without COVID-19 infection compared to SAH individuals post-COVID-19. Participants comprised 40 SAH individuals aged 31 to 80 years old, grouped as SAH with COVID-19 (G1; n = 21) and SAH without COVID-19 (G2; n = 19). CAF was assessed via heart rate variability (HRV), measuring R–R intervals during a 10-min supine period. Four HRV indices were analyzed through symbolic analysis: 0V%, 1V%, 2LV%, and 2UV%. FC assessment was performed by a 6-min walk test (6MWT). G1 and G2 showed no significant differences in terms of age, anthropometric parameters, clinical presentation, and medication use. G2 exhibited superior 6MWT performance, covering more distance (522 ± 78 vs. 465 ± 59 m, p < 0.05). Specifically, G2 demonstrated a moderate positive correlation between 6MWT and the 2LV% index (r = 0.58; p < 0.05). Shorter walking distances were observed during 6MWT in SAH individuals post-COVID-19. However, the study did not find impaired cardiac autonomic function in SAH individuals post-COVID-19 compared to those without. This suggests that while COVID-19 impacted FC, CAF remained relatively stable in this population. Full article
(This article belongs to the Special Issue Multidisciplinary and Personalized Approach for Post-COVID-19 Syndrome)
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10 pages, 1427 KiB  
Communication
Sleep Quality Aspects in Post-COVID-19 Patients
by Ioana Munteanu, Monica Marc, Constantin Gheorghevici, George Alexandru Diaconu, Nicolae Feraru, Dragos Sion, Roxana Maria Nemes and Beatrice Mahler
J. Pers. Med. 2023, 13(7), 1125; https://doi.org/10.3390/jpm13071125 - 11 Jul 2023
Cited by 1 | Viewed by 936
Abstract
In this observational cohort study, sleep quality in post-COVID-19 patients was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. This study aimed to examine aspects of sleep quality in patients who have undergone SARS-CoV-2 infection and if there is a pattern of [...] Read more.
In this observational cohort study, sleep quality in post-COVID-19 patients was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. This study aimed to examine aspects of sleep quality in patients who have undergone SARS-CoV-2 infection and if there is a pattern of progression or regression over time (6 months). We also observed and analyzed the results in order to identify any possible links between the severity of COVID-19 and sleep quality as measured by the PSQI questionnaire. The study group consisted of 65 adult patients with confirmed SARS-CoV-2 infection who were referred to a pulmonologist for evaluation. Sleep quality was impacted at a high rate in post-COVID-19 patients, quantified by a PSQI score ≥5. Out of 65 patients, 51% of them had scores greater than or equal to 5. Sleep was subjectively reported as unsatisfactory predominantly in mild and moderate COVID-19 patients. According to the PSQI score and a 6-month follow-up, many patients presented persistency in poor sleep quality. Investigation and individualized treatment of sleep disorders in post-COVID-19 patients should be part of the routine pneumological control, as improvement in sleep quality has an impact not only on the health but also on the psychological state of patients. Educating patients about the importance of sleep and sleep quality impairment should be a primary concern. Full article
(This article belongs to the Special Issue Multidisciplinary and Personalized Approach for Post-COVID-19 Syndrome)
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17 pages, 310 KiB  
Article
Promising Markers of Inflammatory and Gut Dysbiosis in Patients with Post-COVID-19 Syndrome
by Ekaterina Sorokina, Alisa Pautova, Oleg Fatuev, Vladislav Zakharchenko, Alexander Onufrievich, Andrey Grechko, Natalia Beloborodova and Ekaterina Chernevskaya
J. Pers. Med. 2023, 13(6), 971; https://doi.org/10.3390/jpm13060971 - 08 Jun 2023
Cited by 6 | Viewed by 1497
Abstract
Post-COVID-19 syndrome is a complex of different symptoms, which results in a multisystemic impairment after the suffering from COVID-19 infection. The aim of the study was to reveal the clinical, laboratory, and gut disorders in patients with post-COVID-19 syndrome (n = 39) [...] Read more.
Post-COVID-19 syndrome is a complex of different symptoms, which results in a multisystemic impairment after the suffering from COVID-19 infection. The aim of the study was to reveal the clinical, laboratory, and gut disorders in patients with post-COVID-19 syndrome (n = 39) before and after taking part in the 14-day complex program of rehabilitation. A complete blood count, coagulation test, blood chemistry, biomarkers, and metabolites in serum samples, and gut dysbiosis were revealed in patients on the day of admission and after 14-day rehabilitation, in comparison with the variables of healthy volunteers (n = 48) or with reference ranges. On the day of discharge, patients noted an improvement in respiratory function, general well-being, and mood. At the same time, the levels of some metabolic (4-hydroxybenzoic, succinic, fumaric acids) and inflammatory (interleukin-6) variables, which were increased on admission, did not reach the level of healthy people during the rehabilitation program. Taxonomy disbalance was observed in patients’ feces, namely, a high level of total bacterial mass, a decrease in the number of Lactobacillus spp., and an increase in pro-inflammatory microorganisms. The authors suggest that the post-COVID-19 rehabilitation program should be personalized, considering the patient’s state together with not only the baseline levels of biomarkers, but also with the individual taxonomy of the gut microbiota. Full article
(This article belongs to the Special Issue Multidisciplinary and Personalized Approach for Post-COVID-19 Syndrome)
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