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Advances in the Diagnosis and Treatment of Kidney Disease
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Advances in the Diagnosis and Treatment of Kidney Disease

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (10 August 2023) | Viewed by 4778

Special Issue Editors

Dr. Shen-ju Gou

E-Mail Website
Guest Editor
West China Hospital of Sichuan University, Chengdu, China
Interests: ANCA-associated vasculitis; anti-glomerular basement disease; lupus nephritis; acute kidney disease
Dr. Liang Ma

E-Mail
Guest Editor
Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu 332001, China
Interests: fibrotic kidney diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The incidence of kidney disease is very high. Uremia, the renal endpoint of all kinds of kidney disease, impose a heavy burden on society. In recent years, many breakthroughs have been made in the pathogenesis of primary kidney disease, secondary kidney disease, and inherited kidney disease. Many new discoveries have been made in the search for molecular biomarkers of kidney disease. Clinical trials of new drugs for kidney disease have contributed greatly to the progress in treatment.

The aim of this Special Issue is to provide a publishing platform for the discoveries and progress in all kinds of kidney diseases. Basic research focused on the pathogenesis, clinical trials of new drugs, and reviews of the diagnosis and treatment of kidney diseases are welcome for submission. We hope that this Special Issue will shed light on the pathogenesis of kidney disease and promote progress in the diagnosis and treatment of kidney diseases. We invite original research, reviews, etc., that focus on the latest research progress in the diagnosis and treatment of kidney diseases.

Dr. Shen-ju Gou
Dr. Liang Ma
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • glomerulonephritis
  • acute kidney injury
  • secondary kidney disease
  • diabetic kidney disease
  • antineutrophil cytoplasmic antibody-associated vasculitis
  • lupus nephritis
  • monoclonal immunoglobulin nephropathy
  • hereditary nephropathy

Published Papers (3 papers)

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Research

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11 pages, 1696 KiB  
Article
Incidental Indeterminate Renal Lesions: Distinguishing Non-Enhancing from Potential Enhancing Renal Lesions Using Iodine Quantification on Portal Venous Dual-Layer Spectral CT
by Simone van der Star, Pim A. de Jong and Madeleine Kok
J. Pers. Med. 2023, 13(11), 1546; https://doi.org/10.3390/jpm13111546 - 28 Oct 2023
Viewed by 804
Abstract
The purpose of our study is to determine a threshold for iodine quantification to distinguish definitely non-enhancing benign renal lesions from potential enhancing masses on portal venous dual-layer spectral computed tomography (CT) to reduce the need for additional multiphase CT. In this single-center [...] Read more.
The purpose of our study is to determine a threshold for iodine quantification to distinguish definitely non-enhancing benign renal lesions from potential enhancing masses on portal venous dual-layer spectral computed tomography (CT) to reduce the need for additional multiphase CT. In this single-center retrospective study, patients (≥18 years) scanned between April 2021 and January 2023 following the local renal CT protocol were included. Exclusion criteria were patients without renal lesions, lesions smaller than 10 mm, only fat-containing lesions, abscesses or infarction, follow-up after radiofrequent ablation, wrong scan protocol, or artefacts. Scans were performed on a dual layer detector-based spectral CT (CT 7500, Philips Healthcare, Best, The Netherlands). Iodine concentration (mgI/mL) in renal lesions was determined using spectral data. Analyses were performed for all lesions and for lesions of >30 HU on portal venous CT. Enhancement on multiphase CT (≥20 ΔHU from true unenhanced (TUE) to portal venous phase (PVP) CT) was used as reference standard. To determine thresholds for iodine concentration receiver operating characteristic (ROC) curves, area under the curve (AUC) and 95% confidence intervals were calculated. To obtain thresholds for definite (non-)enhancement, 100% sensitivity with maximum specificity and 100% specificity with maximum sensitivity were noted. Data were measured using one reader. To assess interobserver agreement, a second reader performed measurements on the PVP CT scans. A total of 103 patients (62 years ± 14, 68 men) were included. We measured 328 renal lesions, 56 enhancing lesions (17%) in 38 patients and 272 non-enhancing lesions (83%) in 86 patients. The threshold for non-enhancing lesions was 0.76 mgI/mL or lower (100% sensitivity, 76% specificity). The threshold for a definite enhancing mass was 1.69 mgI/mL or higher (100% specificity, 78% sensitivity). A total of 77% of indeterminate lesions (>30 HU on PVP CT) in our study could be definitely characterized. Renal lesions can be definitively classified as non-enhancing or enhancing on PVP spectral CT using thresholds of 0.76 mgI/mL or 1.69 mgI/mL, respectively, eliminating the need for multiphase imaging. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Treatment of Kidney Disease)
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Other

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6 pages, 739 KiB  
Case Report
Crescentic Glomerulonephritis Due to Enterococcal Endocarditis
by Dragan Klarić, Marta Žutelija, Petar Šenjug, Marta Klarić and Danica Galešić Ljubanović
J. Pers. Med. 2023, 13(8), 1212; https://doi.org/10.3390/jpm13081212 - 30 Jul 2023
Viewed by 922
Abstract
Glomerulonephritis following an enterococcal endocarditis is an extremely rare and life-threatening condition. We present the case of a 71-year-old patient with rapidly progressive glomerulonephritis following enterococcal endocarditis after surgical replacement of the aortic valve. The combination of antibiotic therapy, corticosteroid therapy and haemodialysis [...] Read more.
Glomerulonephritis following an enterococcal endocarditis is an extremely rare and life-threatening condition. We present the case of a 71-year-old patient with rapidly progressive glomerulonephritis following enterococcal endocarditis after surgical replacement of the aortic valve. The combination of antibiotic therapy, corticosteroid therapy and haemodialysis led to an improvement in renal function; however, the severity of cardiac deterioration resulted in a fatal outcome. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Treatment of Kidney Disease)
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16 pages, 1366 KiB  
Systematic Review
Impact of Thyroid Cancer Treatment on Renal Function: A Relevant Issue to Be Addressed
by Rossella Di Paola, Ananya De, Anna Capasso, Sofia Giuliana, Roberta Ranieri, Carolina Ruosi, Antonella Sciarra, Caterina Vitagliano, Alessandra F. Perna, Giovambattista Capasso and Mariadelina Simeoni
J. Pers. Med. 2023, 13(5), 813; https://doi.org/10.3390/jpm13050813 - 11 May 2023
Cited by 1 | Viewed by 2615
Abstract
Thyroid cancers require complex and heterogeneous therapies with different impacts on renal function. In our systematic literature review, we analyzed several aspects: renal function assessment, the impact of radiotherapy and thyroid surgery on kidney functioning, and mechanisms of nephrotoxicity of different chemotherapy, targeted [...] Read more.
Thyroid cancers require complex and heterogeneous therapies with different impacts on renal function. In our systematic literature review, we analyzed several aspects: renal function assessment, the impact of radiotherapy and thyroid surgery on kidney functioning, and mechanisms of nephrotoxicity of different chemotherapy, targeted and immunologic drugs. Our study revealed that the renal impact of thyroid cancer therapy can be a limiting factor in all radiotherapy, surgery, and pharmacological approaches. It is advisable to conduct a careful nephrological follow-up imposing the application of body surface based estimated Glomerular Filtration Rate (eGFR) formulas for the purpose of an early diagnosis and treatment of renal failure, guaranteeing the therapy continuation to thyroid cancer patients. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Treatment of Kidney Disease)
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