Clinical Decisions in Connective Tissue Disease

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Evidence Based Medicine".

Deadline for manuscript submissions: closed (10 March 2024) | Viewed by 2801

Special Issue Editor


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Guest Editor
Faculty of Medicine, Adjunct of Internal Medicine, University Hospital of Salamanca (SACYL), 37007 Salamanca, Spain
Interests: Wernicke's encephalopathy; alcoholism; meta-analysis systemic review; connective tissue diseases

Special Issue Information

Dear Colleagues, 

Connective tissue diseases are a field in which most of the evidence described, regarding diagnosis and treatment, is scant and based mainly on very few randomized studies, case series, or, for the rarest diseases, isolated clinical cases. For all of these reasons, before beginning clinical trials or studies with a higher degree of evidence, it is necessary to know the state of knowledge through systematic reviews or meta-analyses. For this reason, I consider the possibility that this type of work can contribute to the scientific community to be very high, and more so in specific fields that are so infrequent within connective tissue diseases such as autoinflammatory syndromes, some types of immune-mediated inflammatory myopathies, or even responses to certain drugs in rare diseases. All of this is to give some examples. For all of the aforementioned reasons, we invite authors to send their articles related to these topics.

Dr. Antonio-Javier Chamorro
Guest Editor

Manuscript Submission Information

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Keywords

  • systematic review
  • meta-analysis
  • connective tissue diseases
  • autoimmune diseases
  • immune system diseases

Published Papers (1 paper)

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8 pages, 1980 KiB  
Case Report
Successful Treatment of SAPHO Syndrome Complicated with Ankylosing Spondylitis by Secukinumab: A Case Report
by Wei Tu, Daan Nie, Yuxue Chen, Cheng Wen and Zhipeng Zeng
J. Pers. Med. 2023, 13(3), 516; https://doi.org/10.3390/jpm13030516 - 13 Mar 2023
Cited by 2 | Viewed by 2505
Abstract
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is characterized by a wide range of dermatological and musculoskeletal manifestations, and its outcome has recently been improved greatly by optimizing management. However, the treatment strategies are not standardized and require further refinement. Secukinumab, a [...] Read more.
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is characterized by a wide range of dermatological and musculoskeletal manifestations, and its outcome has recently been improved greatly by optimizing management. However, the treatment strategies are not standardized and require further refinement. Secukinumab, a fully human monoclonal antibody targeting IL-17A, is approved for the treatment of autoimmune psoriasis, psoriatic arthritis (PsA), and ankylosing spondylitis (AS). Here, a 53-year-old man was diagnosed with AS, and he presented scattered pustulosis in both hands and feet with a 5-year history of recurrent lumbosacral area pain and abnormal pain in the neck and front chest area. Secukinumab improved the patient’s cutaneous lesion and prevented musculoskeletal pain by substituting adalimumab. Although only a few cases have been reported that secukinumab can effectively treat SAPHO syndrome complicated with AS, the efficacy remains controversial. Therefore, we hope to provide a novel valuable therapeutic strategy for SAPHO syndrome management, particularly in patients with skin lesions. Full article
(This article belongs to the Special Issue Clinical Decisions in Connective Tissue Disease)
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