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Special Issues
Pregnancy Complication and Precision Medicine 2.0
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Special Issue "Pregnancy Complication and Precision Medicine 2.0"

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 25 September 2023 | Viewed by 1851

Special Issue Editors

Dr. Ambrogio P. Londero

E-Mail Website
Guest Editor
Department of Neurology, Rehabilitation, Ophtalmology, Genetics, Maternal and Infant Health (DiNOGMI), 16132 Genova, Italy
Interests: biostatistics; gynecological cancers; pregnancy complications
Special Issues, Collections and Topics in MDPI journals
Dr. Arrigo Fruscalzo

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Cantonal Hospital Fribourg, 1708 Fribourg, Switzerland
Interests: endometriosis; elasticity imaging technology; pregnancy complications
Special Issues, Collections and Topics in MDPI journals
Dr. Serena Bertozzi

E-Mail Website
Guest Editor
Chirurgia Senologica, ASU FC (University Hospital of Udine), 33100 Udine, Italy
Interests: breast cancer; nanotechnology; HIPEC; carcinosis; metastasis; surgery; skin cancer; endoscopy
Dr. Bruna Corradetti

E-Mail Website
Guest Editor
1. Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA
2. Swansea University Medical School, Singleton Park, Swansea SA2 8PP, Wales, UK
Interests: immunotherapy; stem cells; immunomodulation; RNA therapeutics; exosomes; tissue engineering; ovarian cancer; macrophages

Special Issue Information

Dear Colleagues,

Precision medicine represents a bold research area with the potential to revolutionize the way we approach and treat diseases. Alongside nanotechnology and molecular medicine, precision medicine enables the specific delivery of therapeutic agents to cells and organs of interest, thus improving treatment outcomes and reducing side effects. In the obstetric field, several opportunities exist for existing diagnostic and treatment tools as well as for the development of innovative strategies that are driven by multiple factors, including fetal growth restriction, preterm birth, fetal abnormalities, and labor monitoring. In addition, maternal tumors in pregnancy could benefit from precise medicine development, reducing cancer treatment burden and improving pregnancy outcomes. This Special Issue aims to provide a collection of manuscripts providing an overview of the current status of precision medicine in pregnancy complications.

We welcome research articles or reviews on pregnancy complications and precision medicine. Topics of interest from the perspective of personalized medicine and pregnancy complication include (but are not limited to) the following:

  • Drug targeting and nanotechnology and integration with individualized therapy (i.e., novel therapeutics: genetic-based, nanotechnology, targeting strategies);
  • Omics-based studies of disease risk, disease prognosis, and response to therapy or prediction-based drug safety;
  • Biomarker identification and application;
  • Pharmacogenomics: genetics and biochemistry of drug uptake, action, and metabolism;
  • Advancements in technologies and resources (sequencing technologies, expression analysis, bioinformatics, and biostatistics);
  • Personalization of omics-based nondrug-related health interventions;
  • Regulation and bioethics in personalized medicine in obstetrics and gynecology.

Dr. Ambrogio P. Londero
Dr. Arrigo Fruscalzo
Dr. Serena Bertozzi
Dr. Bruna Corradetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • precision medicine
  • nanomedicine
  • nanotechnology
  • growth-restricted fetuses
  • pre-eclampsia
  • preterm births
  • diabetes
  • ectopic pregnancy
  • maternal cancer

Published Papers (2 papers)

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Research

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Communication
Anthropometric Features and Third-Fourth Degree Perineal Tears
by
Arrigo Fruscalzo
,
Alice Novak
,
Camilla Somma
,
Anjeza Xholli
,
Virginia Michelerio
,
Federico Prefumo
,
Ambrogio P. Londero
and
Angelo Cagnacci
J. Pers. Med. 2023, 13(3), 545; https://doi.org/10.3390/jpm13030545 - 18 Mar 2023
Viewed by 367
Abstract
The main objective of this study was to evaluate the association between maternal and fetal anthropometric characteristics and third- and fourth-degree perineal tears. This retrospective cohort study considered all consecutive pregnancies from 2011 to 2017 at a single Institution. The inclusion criteria were: [...] Read more.
The main objective of this study was to evaluate the association between maternal and fetal anthropometric characteristics and third- and fourth-degree perineal tears. This retrospective cohort study considered all consecutive pregnancies from 2011 to 2017 at a single Institution. The inclusion criteria were: singletons who delivered vaginally during the study period, the presence of information on maternal pre-pregnancy weight, maternal height, and weight of the newborn. The feto-maternal body-mass index (BMI) was calculated as neonatal weight in kg on maternal height in squared meters (kg/m2). In total, 5397 singleton-term pregnancies were included; the prevalence of third-fourth-degree perineal tears was 0.47%. The most predictive factors were: nulliparity, feto-maternal BMI, neonatal weight, gestational age at delivery, and neonatal head circumference. After adjustment in multivariate analysis, the only independent predictors were nulliparity and fetomaternal BMI. The AUC of the final multivariate model was 73.54% (95% CI 65.65–81.42). Furthermore, feto-maternal BMI and gestational age had a significant direct correlation. Nulliparity and feto-maternal BMI are the two best predictors for third and fourth-degree perineal tears in our setting. Confirming this association in future research and integrating it into a decision algorithm on delivery timing could reduce obstetric damage to the anal sphincter. Full article
(This article belongs to the Special Issue Pregnancy Complication and Precision Medicine 2.0)
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Review

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Review
Maternity Blues: A Narrative Review
by
Valentina Tosto
,
Margherita Ceccobelli
,
Emanuela Lucarini
,
Alfonso Tortorella
,
Sandro Gerli
,
Fabio Parazzini
and
Alessandro Favilli
J. Pers. Med. 2023, 13(1), 154; https://doi.org/10.3390/jpm13010154 - 13 Jan 2023
Viewed by 1141
Abstract
Puerperium is a period of great vulnerability for the woman, associated with intense physical and emotional changes. Maternity blues (MB), also known as baby blues, postnatal blues, or post-partum blues, include low mood and mild, transient, self-limited depressive symptoms, which can be developed [...] Read more.
Puerperium is a period of great vulnerability for the woman, associated with intense physical and emotional changes. Maternity blues (MB), also known as baby blues, postnatal blues, or post-partum blues, include low mood and mild, transient, self-limited depressive symptoms, which can be developed in the first days after delivery. However, the correct identification of this condition is difficult because a shared definition and well-established diagnostic tools are not still available. A great heterogenicity has been reported worldwide regarding MB prevalence. Studies described an overall prevalence of 39%, ranging from 13.7% to 76%, according to the cultural and geographical contexts. MB is a well-established risk factor for shifting to more severe post-partum mood disorders, such as post-partum depression and postpartum psychosis. Several risk factors and pathophysiological mechanisms which could provide the foundation of MB have been the object of investigations, but only poor evidence and speculations are available until now. Taking into account its non-negligible prevalence after childbirth, making an early diagnosis of MB is important to provide adequate and prompt support to the mother, which may contribute to avoiding evolutions toward more serious post-partum disorders. In this paper, we aimed to offer an overview of the knowledge available of MB in terms of definitions, diagnosis tools, pathophysiological mechanisms, and all major clinical aspects. Clinicians should know MB and be aware of its potential evolutions in order to offer the most timely and effective evidence-based care. Full article
(This article belongs to the Special Issue Pregnancy Complication and Precision Medicine 2.0)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: hyperparathyroidism in Pregnancy
Authors: Gefsi Mintziori
Affiliation: Aristotle University of ThessalonikiThis link is disabled., Thessaloniki, Greece
Abstract: hyperparathyroidism in Pregnancy

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