Precision Medicine for Hematological Tumors
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".
Deadline for manuscript submissions: closed (15 July 2023) | Viewed by 113
Special Issue Editors
Interests: molecular mechanisms of hematopathogenesis; acute lymphoblastic leukemia; lymphoma
Interests: hematopoietic stem cells; epigenetic regulations; leukemia stem cells; acute myeloid leukemia
Interests: molecular mechanisms of hematopathogenesis; hereditary hematological disorders; T-cell acute lymphoblastic leukemia
Special Issue Information
Dear Colleagues,
Hematological tumors are blood tumors with complex heterogeneity. Previous morphology was used to classify the disease categories. Due to improvements in technology, especially the next-generation sequence, precise gene mutations and chromosome translocations are identified. People found that different abnormalities have specific mechanisms to promote the development of hematological tumors. Nowadays, molecular abnormalities are widely accepted to classify the disease categories. Based on the molecular mechanisms, many drugs and therapeutic methods are developed. The most successful one is the tyrosine kinase inhibitor (TKI). The TKI targets the BCR-ABL fusion gene which drives chronic myeloid leukemia (CML) development. The CML patients receiving TKI treatment could be expected to have a survival instinct and quality of life of the age-matched healthy people. Besides the TKI, gilteritinib (target FLT3-ITD mutation), venetoclax (target BCL-2), and other inhibitors are under development; chimeric antigen receptor T-cells (CAR-T cells), antibodies, gene editing, and other methods are created. These drugs and methods completely changed treatment strategies of hematological tumor. The therapies goes into the era of personalized treatment.
In this Special Issue, we aim to focus on the precision medicine for hematological tumors, original research articles and review articles are welcome.
Prof. Dr. Hongling Peng
Dr. Yue Sheng
Dr. Zhao Cheng
Guest Editors
Manuscript Submission Information
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Keywords
- hematological tumors
- precision medicine
- targeted drugs
- therapeutic methods
- personalized treatment
- gene mutations
- molecular mechanisms