Dear Colleagues,

Female breast can suffer from a wide spectrum of pathologies, ranging from inflammatory diseases to benign and malignant tumors. Women face numerous risk factors, such as age and familiarity, nutrition, endogenous and/or exogenous hormonal stimulation, as well as breast density. To reduce the risk and harm of these conditions, primary prevention is fundamental, and the importance of early diagnosis has been widely demonstrated.

Mammography represents the gold standard for breast cancer screening in women aged 40 and over (especially 50–69 years old), with different guidelines proposed around the world. Although screening is considered the main instrument to achieve early diagnosis, its effectiveness is highly debated due to the presence of false-positive and false-negative cases, interval cancers and overdiagnosis, which are associated with discomfort and/or potential psychological harm for the women.

This Special Issue aims to evaluate the state of the art of the use of mammography, with particular attention to the use of digital breast tomosynthesis (DBT), in breast disease screening and diagnosis for both asymptomatic women and symptomatic outpatients.

In particular, we will try to deepen and clarify the use of DBT alone or in association with other imaging techniques (e.g., ultrasound, standard digital mammography, magnetic resonance imaging), in addition to analyzing the advantages of personalized screening for breast cancer.

Finally, focus will be also extended to the socio-economic and psychological impact of screening on both the general population and the health system, as well as its medico-legal implications in the current practice.

This Special Issue aims to present and discuss all these aspects. Original research articles and reviews are welcome. Research areas may include (but are not limited to) all the aforementioned topics.

Dr. Daniele Ugo Tari
Dr. Fabio Pinto
Guest Editors

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• breast cancer 
• screening 
• breast disease 
• public health 
• mammography 
• digital breast tomosynthesis (DBT) 
• personalized screening