Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
2.6
3.4
Journals
JPM
Special Issues
Precision Medicine in Otorhinolaryngology: A New Challenge to Improve Outcomes...
share announcement

Precision Medicine in Otorhinolaryngology: A New Challenge to Improve Outcomes in ENT Disease

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 20 April 2024 | Viewed by 4222

Special Issue Editor

Dr. Eugenio De Corso

E-Mail Website
Guest Editor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
Interests: rhinology; otorhinolaryngology; head and neck surgery; personalized medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce the launch of a new Special Issue, “Precision Medicine in Otorhinolaryngology: A New Challenge to Improve Outcomes in ENT Disease”, a continuation of a previously successfully Special Issue.

Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. It represents an exciting opportunity to improve the future of individualised healthcare for patients. One of the aims of personalized medicine is to improve efficiency and quality of care, while reducing side effects. In the last few years, our increased knowledge about the classification of diseases on a molecular level has been the basis for personalized medicine in otorhinolaryngology, especially in the field of chronic disease, increasing long-term control.

Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains, such as allergy chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. Physicians treating patients with chronic disorders might find precision medicine extremely useful to find reports on the predictors of success of medical or surgical interventions. Prediction of the success of treatments is crucial to allow the patient to become an active partner in the decision-making process of medical or surgical treatment.

In the last few years, in the field of audiology, the potential application of precision medicine in hearing loss has been discussed. By integrating precision medicine principles into translational hearing loss research and clinical practice, hearing specialists are uniquely positioned to effectively treat the heterogeneous causes and manifestations of HL on an individualized basis.

The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of treatment plans is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions.

Several factors are driving the increased interest in precision medicine in otorhinolaryngology. Rhinology, head and neck cancers and hearing loss, as well as some other otolaryngology-related conditions, represent an opportunity to use precision-guided therapies. For this reason, we proposed this Special Issue of the Journal of Personalized Medicine in order to collect papers about personalized medicine in all the fields of otorhinolaryngology. This Special Issue will include studies that explore new aspect of personalized medicine using basic science, clinical and population-based approaches.

Dr. Eugenio De Corso
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • target therapy
  • chronic rhinosinusitis
  • head and neck oncology
  • allergic rhinitis
  • endotyping
  • phenotyping
  • rhinology
  • otology
  • laryngology
  • immunotherapy
  • biomarkers

Related Special Issue

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

10 pages, 1541 KiB  
Article
The Morphology of Nasal Polyps in Different Age Groups: Histopathological Features
by Vincenzo Fiorentino, Maurizio Martini, Cosimo Galletti, Cristina Pizzimenti, Mariausilia Franchina, Antonio Ieni, Guido Fadda, Bruno Galletti and Giovanni Tuccari
J. Pers. Med. 2024, 14(4), 414; https://doi.org/10.3390/jpm14040414 - 14 Apr 2024
Viewed by 287
Abstract
Background: Nasal polyps (NPs) represent the end-stage manifestation of chronic rhinosinusitis (CRS), a relatively common pathological condition encountered in all ages of life. Methodology: The aim of our study was to evaluate the histological features and inflammatory cellular components of NPs in a [...] Read more.
Background: Nasal polyps (NPs) represent the end-stage manifestation of chronic rhinosinusitis (CRS), a relatively common pathological condition encountered in all ages of life. Methodology: The aim of our study was to evaluate the histological features and inflammatory cellular components of NPs in a retrospective cohort (143 cases) of pediatric, adult and elderly populations in order to discuss the possible morphological age-related differences statistically documented. Results: In the pediatric group, the inflammatory infiltrate presented many eosinophils mixed with lymphocytes, while in the adult population, lymphocytes and plasma cells were mainly evident, frequently with a perivascular distribution or with the formation of subepithelial lymphoid nodules. In the elderly population, inflammation was less evident and was associated with cavernous-like angecthatic structures with thrombotic stratification. Nearly all morphological findings exhibited statistically significant values among differently aged subgroups. Conclusions: Our results support the presence of histological specificities of NPs at different ages of life, providing new insight into the etiopathogenesis of NPs. The future role of biological therapies, mainly in cases refractory to already available standard medical and surgical treatments, may be analyzed by a prospective study using a larger cohort with a long-term evaluation also in relation to a possible relapse. Full article
(This article belongs to the Special Issue Precision Medicine in Otorhinolaryngology: A New Challenge to Improve Outcomes in ENT Disease)
►▼ Show Figures

Figure 1

10 pages, 247 KiB  
Article
Chronic Rhinosinusitis with Nasal Polyps: A Survey on Routine Management and Evaluation of Disease Control in Practice
by Eugenio De Corso, Giancarlo Ottaviano, Carlotta Pipolo, Elena Cantone, Davide Mattavelli, Matteo Alicandri-Ciufelli, Daniela Lucidi, Marco Caminati, Gianenrico Senna, Carlo Cavaliere, Angelo Ghidini, Stefania Gallo, Alberto Macchi, Sara Torretta, Veronica Seccia, Massimiliano Garzaro, Gian Luca Fadda, Matteo Trimarchi, Ernesto Pasquini, Fabio Pagella, Frank Rikki Canevari, Andrea Preti, Ignazio La Mantia and Jacopo Galliadd Show full author list remove Hide full author list
J. Pers. Med. 2023, 13(11), 1531; https://doi.org/10.3390/jpm13111531 - 26 Oct 2023
Cited by 2 | Viewed by 1056
Abstract
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease with a significant impact on quality of life. The overall goal of CRSwNP management, as with other chronic conditions, is to achieve “disease control”, and for that reason, a definition of control of disease [...] Read more.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease with a significant impact on quality of life. The overall goal of CRSwNP management, as with other chronic conditions, is to achieve “disease control”, and for that reason, a definition of control of disease is pivotal in deciding the best treatment strategy. Although many staging systems have already been developed to evaluate the disease, disease control is not yet to be standardized, and a specific tool that is consistently applied and accepted by all practitioners is still missing in daily clinical practice. To gain an overview of the implementation and limitations of existing guidelines and to shed light on real-life definitions of control and disease severity, we conducted a nationwide survey of otorhinolaryngologists routinely treating CRSwNP to identify unmet clinical needs in Italy. The results showed homogeneous responses regarding the knowledge contained in international guidelines while highlighting the difficulty of their implementation in day-to-day practice. Respondents called attention to the importance of clinical symptoms, giving more weight to the patient’s perspective. Among the symptoms to be considered, respondents emphasized nasal obstruction, followed by loss of sense of smell and rhinorrhea. Others also believe that the physician’s perspective should be considered, and the inclusion of endoscopy as a measure of control was warranted by many. The need for a specific tool that is able to unequivocally ascertain disease control is increasingly pivotal in this new era of biologics for treating CRSwNP. Full article
(This article belongs to the Special Issue Precision Medicine in Otorhinolaryngology: A New Challenge to Improve Outcomes in ENT Disease)
14 pages, 1914 KiB  
Article
Effectiveness of Dupilumab in the Treatment of Adult and Older Adult Patients with Severe, Uncontrolled CRSwNP
by Giancarlo Ottaviano, Eugenio De Corso, Tommaso Saccardo, Leandro Maria D’Auria, Sonny Zampollo, Giuseppe D’Agostino, Edoardo Mairani, Gabriele De Maio, Bruno Scarpa, Christian Bacci and Vittorio Favero
J. Pers. Med. 2023, 13(8), 1241; https://doi.org/10.3390/jpm13081241 - 10 Aug 2023
Cited by 1 | Viewed by 1556
Abstract
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease that significantly impacts patients’ quality of life. New therapeutic strategies and in particular biologic treatments are now available for these patients. It has been demonstrated that Dupilumab (an anti IL-4/IL-13 biologic drug) is [...] Read more.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disease that significantly impacts patients’ quality of life. New therapeutic strategies and in particular biologic treatments are now available for these patients. It has been demonstrated that Dupilumab (an anti IL-4/IL-13 biologic drug) is effective in reducing the size of nasal polyps and in improving patients’ symptoms and thus, quality of life. No real-world studies examining Dupilamab’s efficacy in the elderly with respect to other adult age groups have as yet been carried out. The aim of this multicentric study was to evaluate Dupilumab’s efficacy in young–middle adults as opposed to an older adult population affected by severe, uncontrolled CRSwNP. Of the 96 patients included in the study, 22 were 65 years old or older. Significant improvements were observed in all the parameters considered in both age groups after treatment was begun (T0 mean values for SNOT-22 = 58.5 ± 20.3, VAS NO = 7.6 ± 2.2, VAS smell = 8.6 ± 2.1, NPS = 5.6 ± 1.4, PNIF = 101.6 ± 59.4, S’S = 5.1 ± 3.1), T4 mean values for SNOT-22 = 15.1 ± 12.7, VAS NO = 1.7 ± 1.8, VAS smell = 2.4 ± 3, NPS = 1.7 ± 1.7, PNIF = 162.4 ± 43.2, S’S = 10.4 ± 3.7) (p < 0.0001). No differences in the variables considered were observed between the two age groups during the study, with the exception of the Peak Nasal Inspiratory Flow (PNIF), which was marginally higher; this was also the case according to multivariate analyses (p = 0.008) in the young–middle adult group with respect to the elderly one (p = 0.07). At multivariate analyses, asthma and the female sex negatively influenced the PNIF values (p = 0.001 and p = 0.012, respectively). Age negatively influenced the Visual Analog Scale (VAS) for nasal obstruction (p = 0.0032) and Endoscopic Sinus Surgery (ESS) negatively influenced the patents’ olfactory performance (p = 0.028) to the same degree in both groups. Dupilumab was found to be effective to the same degree in both age groups. It can be considered a safe and reliable option for the treatment of elderly patients with severe, uncontrolled CRSwNP. Full article
(This article belongs to the Special Issue Precision Medicine in Otorhinolaryngology: A New Challenge to Improve Outcomes in ENT Disease)
►▼ Show Figures

Figure 1

15 pages, 970 KiB  
Article
Pectoralis Major in Salvage Total Laryngectomy after Irradiation: Morbidity, Mortality, Functional, and Oncological Results in a Referral Center in Egypt
by Mahmoud Abdelghany, Ayman Amin, Emilia Degni, Claudia Crescio, Asem Elsani M. A. Hassan, Tarek Ftohy and Francesco Bussu
J. Pers. Med. 2023, 13(8), 1223; https://doi.org/10.3390/jpm13081223 - 01 Aug 2023
Cited by 1 | Viewed by 854
Abstract
Background: Nonsurgical organ preservation protocols have seen a large diffusion worldwide in the last decades. Their oncological and functional effectiveness in a real-world setting has been recently questioned because of the high morbidity of salvage procedures. The aim of this study is to [...] Read more.
Background: Nonsurgical organ preservation protocols have seen a large diffusion worldwide in the last decades. Their oncological and functional effectiveness in a real-world setting has been recently questioned because of the high morbidity of salvage procedures. The aim of this study is to review the outcomes of postirradiation salvage total laryngectomy (STL) and reconstruction with pectoralis major flap. Methods: This retrospective observational study included 37 cases of STL in the period from January 2015 to December 2021. Data for each patient were extracted from the hospital information system and reviewed. Results: The 3-year overall and disease-specific survival are, respectively, 28% and 51%. Only seven recurrences after salvage surgery were recorded and all of them died from the disease. The other 14 deaths derived from comorbidities, with diabetes being the most significant predictive parameter for overall survival. Also, lower postoperative albumin levels were associated with a higher risk of death. Conclusions: Overall survival after STL and reconstruction with PMMF is low but most deaths are due to comorbidities and not to cancer progression or recurrence. Full article
(This article belongs to the Special Issue Precision Medicine in Otorhinolaryngology: A New Challenge to Improve Outcomes in ENT Disease)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop