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Novel Challenges and Advances in Diseases of the Respiratory System
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Novel Challenges and Advances in Diseases of the Respiratory System

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (10 March 2024) | Viewed by 3211

Special Issue Editors

Dr. Foteini Malli

E-Mail Website
Guest Editor
1. Respiratory Medicine Department, Faculty of Medicine, University of Thessaly, 412 23 Larissa, Greece
2. Professor, Respiratory Disorders Lab, Faculty of Nursing, University of Thessaly, 412 23 Larissa, Greece
Interests: respiratory diseases; pulmonary embolism; interstitial lung diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Ourania S. Kotsiou

E-Mail Website
Guest Editor
1. Respiratory Medicine Department, Faculty of Medicine, University of Thessaly, Larissa, Greece
2. Assistant Professor, Faculty of Nursing, University of Thessaly, Larissa, Greece
Interests: human pathophysiology; clinical and medical research; medical education
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Journal of Personalized Medicine has launched a Special Issue on “Novel Challenges and Advances in Diseases of the Respiratory System”.

Diseases of the respiratory system include a long list of conditions such as chronic obstructive disease, asthma, bronchiectasis, pneumonia, tuberculosis, pleural effusion, lung cancer, interstitial lung diseases, pulmonary embolism, respiratory failure, etc. The prevalence of lung diseases, and especially chronic disorders, has increased throughout the years.

In the contemporary era, there is an emerging need to apply a personalized approach for the prevention, diagnosis, and treatment of diseases, since current research has revealed various subpopulations and subphenotypes within the same diagnosis. Patients that suffer from the same disease may exhibit significant diversities in terms of pathogenesis and clinical characteristics, which call for individualized treatments. As far as respiratory disorders are concerned, in recent years, the accumulation of data has led to drastic advances in molecular and clinical venues, highlighting the diversities in clinical, laboratory, and/or imaging findings, even within the same disease.

We warmly invite you to submit your research to this Special Issue entitled “Novel Challenges and Advances in Diseases of the Respiratory System”. We are calling for studies that address the pathophysiological and clinical issues related to the diseases of the respiratory system.

Dr. Foteini Malli
Dr. Ourania S. Kotsiou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung diseases
  • respiratory system
  • chronic obstructive pulmonary disease
  • asthma
  • bronchiectasis
  • pneumonia
  • tuberculosis
  • pleural effusion
  • lung cancer
  • interstitial lung diseases
  • pulmonary embolism
  • respiratory failure

Published Papers (3 papers)

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Research

13 pages, 281 KiB  
Article
Investigation of Health-Related Quality of Life, Anxiety and Satisfaction in Patients with Pulmonary Embolism
by Foteini Malli, Niki Gkena, Diamantoula Papamichali, Nikoletta Vlaikoudi, Ioanna V. Papathanasiou, Evangelos C. Fradelos, Dimitrios Papagiannis, Erasmia C. Rouka, Dimitrios G. Raptis, Zoe Daniil and Konstantinos I. Gourgoulianis
J. Pers. Med. 2024, 14(4), 393; https://doi.org/10.3390/jpm14040393 - 08 Apr 2024
Viewed by 298
Abstract
Background: Features of post-traumatic stress disorder and anxiety may be present in pulmonary embolism (PE) patients, along with impaired quality of life (QoL). We aim to evaluate health-related QoL, anxiety and satisfaction with life in patients with PE. Methods: Patients with PE were [...] Read more.
Background: Features of post-traumatic stress disorder and anxiety may be present in pulmonary embolism (PE) patients, along with impaired quality of life (QoL). We aim to evaluate health-related QoL, anxiety and satisfaction with life in patients with PE. Methods: Patients with PE were enrolled during their follow-up. All participants completed the Short Form 36 (SF-36) questionnaire, the State–Trait Anxiety Inventory (STAI) X1 and X2 forms, and the Satisfaction with Life Scale (SWLS). Results: 92 PE patients were included (mean age ± SD = 62.50 ± 15.33 years, 56.5% males). The median values of the SF-36 subscales were below the corresponding values of the Greek general population (besides the mental health (MH) subscale). Mean STAIX1 levels were 37.05 ± 11.17 and mean STAIX2 levels were 39.80 ± 10.47. Mean SWLS levels were 23.31 ± 6.58. According to multiple linear regression analysis, the MH and general health subscales were predictive of SWLS levels (F (10.76) = 10.576, p < 0.001, R2 = 0.581). The MH score (β = −0.242, p < 0.01) and STAIX1 level (β = 0.312, p < 0.001) (F (9.77) = 26.445, p < 0.001, R2 = 0.756) were predictive of STAIX2. Conclusions: Patients with PE exhibit slight satisfaction with life, borderline anxiety and impaired HRQoL. Full article
(This article belongs to the Special Issue Novel Challenges and Advances in Diseases of the Respiratory System)
10 pages, 287 KiB  
Article
Lung Ultrasound: A Useful Prognostic Tool in the Management of Bronchiolitis in the Emergency Department
by Aiza C. Hernández-Villarroel, Alicia Ruiz-García, Carlos Manzanaro, Regina Echevarría-Zubero, Patricia Bote-Gascón, Isabel Gonzalez-Bertolin, Talía Sainz, Cristina Calvo and Mercedes Bueno-Campaña
J. Pers. Med. 2023, 13(12), 1624; https://doi.org/10.3390/jpm13121624 - 21 Nov 2023
Viewed by 721
Abstract
Lung ultrasound, a non-invasive bedside technique for assessing paediatric patients with acute respiratory diseases, is becoming increasingly widespread. The aim of this prospective, observational cohort study was to evaluate the effectiveness of a clinical ultrasound score in assessing infants with acute bronchiolitis in [...] Read more.
Lung ultrasound, a non-invasive bedside technique for assessing paediatric patients with acute respiratory diseases, is becoming increasingly widespread. The aim of this prospective, observational cohort study was to evaluate the effectiveness of a clinical ultrasound score in assessing infants with acute bronchiolitis in the emergency department and its ability to accurately identify patients at a higher risk of clinical deterioration. Infants under 6 months of age with clinical symptoms compatible with acute bronchiolitis were enrolled and underwent clinical and lung ultrasound evaluations. The study included 50 patients, the median age of which was 2.2 months (IQR: 1–5), and the primary outcome was respiratory support. Infants requiring invasive or non-invasive ventilation showed higher scores (5 points [IQR: 3.5–5.5] vs. 2.5 [IQR: 1.5–4]). The outcome had an AUC of 0.85 (95%CI: 0.7–0.98), with a sensitivity of 87%, specificity of 64%, and negative predictive value of 96.4% for a score <3.5 points. Children who scored ≥3.5 points were more likely to require respiratory support within the next 24 h (estimated event-free survival of 82.9% compared to 100%, log-rank test p-value = 0.02). The results suggest that integrating lung ultrasound findings into clinical scores when evaluating infants with acute bronchiolitis could be a promising tool for improving prognosis. Full article
(This article belongs to the Special Issue Novel Challenges and Advances in Diseases of the Respiratory System)
12 pages, 621 KiB  
Article
Ultrasonic Evaluation of Diaphragm in Patients with Systemic Sclerosis
by Anja Ljilja Posavec, Stela Hrkač, Josip Tečer, Renata Huzjan Korunić, Boris Karanović, Ivana Ježić, Ivan Škopljanac, Nevenka Piskač Živković and Joško Mitrović
J. Pers. Med. 2023, 13(10), 1441; https://doi.org/10.3390/jpm13101441 - 27 Sep 2023
Viewed by 1189
Abstract
The diaphragm is the most important muscle in respiration. Nevertheless, its function is rarely evaluated. Patients with systemic sclerosis (SSc) could be at risk of diaphragmatic dysfunction because of multiple factors. These patients often develop interstitial lung disease (SSc-ILD) and earlier studies have [...] Read more.
The diaphragm is the most important muscle in respiration. Nevertheless, its function is rarely evaluated. Patients with systemic sclerosis (SSc) could be at risk of diaphragmatic dysfunction because of multiple factors. These patients often develop interstitial lung disease (SSc-ILD) and earlier studies have indicated that patients with different ILDs have decreased diaphragmatic mobility on ultrasound (US). This study aimed to evaluate diaphragmatic function in SSc patients using US with regard to the ILD, evaluated with the Warrick score on high-resolution computed tomography (HRCT), and to investigate associations between ultrasonic parameters and dyspnea, lung function, and other important clinical parameters. In this cross-sectional study, we analyzed diaphragm mobility, thickness, lung function, HRCT findings, Modified Medical Research Council (mMRC) dyspnea scale, modified Rodnan skin score (mRSS), autoantibodies, and esophageal diameters on HRCT in patients with SSc. Fifty patients were enrolled in the study. Patients with SSc-ILD had lower diaphragmatic mobility in deep breathing than patients without ILD. The results demonstrated negative correlations between diaphragmatic mobility and mMRC, mRSS, anti-Scl-70 antibodies, esophageal diameters on HRCT, and a positive correlation with lung function. Patients with SSc who experience dyspnea should be evaluated for diaphragmatic dysfunction for accurate symptom phenotyping and personalized pulmonary rehabilitation treatment. Full article
(This article belongs to the Special Issue Novel Challenges and Advances in Diseases of the Respiratory System)
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