Personalized Diagnosis and Treatment of Oligometastatic Disease

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 25 December 2024 | Viewed by 146

Special Issue Editor

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Guest Editor
Radiation Oncology Unit—ARNAS Civico Hospital, 90100 Palermo, Italy
Interests: radiation oncology; radiotherapy physics; stereotactic radiosurgery; intensity-modulated radiotherapy; adaptive radiotherapy; lung cancer; prostate cancer
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Special Issue Information

Dear Colleagues,

In recent years, our scientific community has witnessed a revolution in the management of metastatic patients, with increasing availability of novel systemic agents able to prolong the survival with negligible impact on quality of life. The concept of oligometastatic disease is gaining attractiveness as an intermediate state between localized and disseminated disease that is potentially suitable for local treatments with the intent to ablate the metastatic foci. The oligometastatic status was postulated in 1995 by Hellman and Weichselbaum, who identified a metastatic disease burden limited to 3–5 lesions and suitable for local treatments, either via surgery or radiotherapy.

Recently, several prospective and retrospective studies support the role of radiotherapy, particularly stereotactic body radiotherapy (SBRT), as a safe and effective tool for patients with oligometastastic disease, with proven benefits also in terms of survival, as confirmed by the long-term results of the SABR-COMET trial. To date, SBRT is routinely applied in clinical practice alone or in combination with novel systemic agents, with an increased use of this therapeutic option thanks to the availability of refined diagnostic modalities. The combination of technological progress along with the improved knowledge of biomolecular factors as potential candidates for target therapies, have led clinicians to consider SBRT beyond the consolidated numerical limit of 3–5 metastases and explore other parameters such as the total tumor volume. In this sense, the definition of oligometastatic disease has been reconsidered and recategorized.

Moreover, new endpoints such as time to next systemic treatment or systemic treatment-free survival have been reported as a means to quantify the real impact of SBRT in the treatment of oligometastatic disease.

This Special Issue aims to collect the available evidence and new developments in this complex disease scenario, which is constantly changing shape under the wave of technological and biological advances.

Dr. Francesco Cuccia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • oligometastatic disease
  • oligorecurrence
  • oligoprogression
  • oligoconsolidation
  • metastasectomy
  • stereotactic body radiotherapy (SBRT)
  • novel systemic agents
  • target therapies
  • chemotherapy
  • immunotherapy

Published Papers

This special issue is now open for submission.
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